Fig. 5
From: ADARs regulate cuticle collagen expression and promote survival to pathogen infection
Loss of adrs results in altered cuticle structure and enhanced susceptibility to several pathogenic bacterial species. A Representative SEM images of the indicated strains after exposure to the bacterial strains indicated. Images were captured and categorized by blinded individuals (see methods) with 15 images available for wildtype animals fed OP50, 10 images available for wildtype animals exposed to PA14, 15 images available for adr-1(-); adr-2(-) animals fed OP50 and 10 adr-1(-); adr-2(-) animals exposed to PA14. Scale bar of image is 20 µm. B, C Representative survival curve (of three biological replicates) for the indicated animals subjected to the slow-killing assay and scored for survival in response to S. aureus (B) and S. enterica (C). Statistical significance was determined using OASIS, ****p < 0.0001, ***p < 0.001. Survival assay biological replicates are provided in Additional file 18: Fig. S18A-D