Fig. 2

Comparison of DNA methylation status between S. aureus-positive (SAP) and healthy control (HC) groups revealed abundant alterations. A A DNA methylation landscape of chromosome 11 (Chr11) illustrating the general methylation status and various DNA methylation alterations. A 50-kb-long window was used to count the corresponding information per track. B Comparison of global methylation level of CpG sites between SAP and HC groups revealed significantly higher global methylation level of SAP group. ***: significant difference (P value = 0.00076). C The distribution of DMCs per chromosome (Chr). The number on the top of each bar represents the percentage of hyper-methylated DMCs to total DMCs located in the corresponding Chr. D The distribution of DMCs in the context of CpG, CHG, and CHH among genomic functional regions. E The count of DMCs collocated in repeat elements, including short and long interspersed retrotransposable elements (SINE and LINE), long terminal repeat retrotransposons (LTR), and DNA transposons (DNA). MHBs: methylation haplotype blocks; dMHBs: differential MHBs; DMCs: differentially methylated cytosines which were counted in the context of CpG, CHG, and CHH, respectively; Hyper/hypo: DMCs were hyper-/hypo-methylated in SAP group compared to HC group; CGI: CpG island. Detailed data on the depicted findings are found in Supplementary Tables 3–6