Fig. 5

Functional enrichment for gene expression associated differential methylation haplotype blocks (GE-dMHBs). A, B Tree-plot showing the clustering of biological process GO terms (A) and enrichment map of four KEGG pathways (B), which were significantly enriched by downregulated differentially expressed genes (DEGs) that were negatively correlated with their overlapped hyper-methylated GE-dMHBs. C Enrichment map of 18 KEGG pathways significantly enriched by upregulated DEGs that negatively correlated with their overlapped hypo-methylated GE-dMHBs. Detailed data on the depicted findings are found in Supplementary Table 15