Fig. 1

The fitness trade-off under various environmental conditions. Hierarchical clustering on the growth phenotypes across multiple conditions, the corresponding correlation plot, and the PAC measurements for each cluster. A denotes the growth profiles from 45 nutritional conditions of 1011 natural yeast strains. B indicates the growth profiles across 35 stress conditions of 975 natural yeast strains. C indicates the growth profiles for 38 genetically diverse yeast strains from 199 conditions. D denotes 13 stress conditions of 52 genetically diverse yeast strains. E denotes the growth profiles for 1008 segregants from a cross between BY and RM strains. We performed hierarchical clustering between the conditions using 1 − Spearman correlation as distance with the average linkage method. We note that the conditions are robustly clustered into two groups (as shown by two black boxes in each correlation plot and PAC index). In A, both 2 and 3 are the optimal number of clusters. In B and C, 2 is the optimal number of clusters. In D, 2 is the optimal number of clusters without singletons in the cluster (K < 6). E is the only phenotype that 2 is not the optimal number of clusters. In the presented analysis, dot sizes are proportional to the magnitude of the Spearman correlation coefficients, with larger dots indicating stronger absolute correlations