Fig. 2

Clustering of growth phenotypes in yeast strains under nutritional and stress conditions. A A heatmap represents growth phenotypes, with each row corresponding to a nutritional condition and each column to a yeast strain. Strains are categorized as “wild type,” “domesticated (dom),” or “unassigned.” Color reflects the growth phenotype, with values scaled by row. Side color bars indicate cluster numbers and clade classes. Hierarchical clustering analysis was performed for each row and column using 1 − the Spearman rank correlation coefficient as the distance metric and the average linkage method for clustering. B Eight yeast strain clusters were determined based on the PAC. The dendrogram across conditions is identical to that in Fig. 1A. C A stacked bar plot shows the frequencies of the three yeast clade classes across each cluster, with wild strains enriched in specific clusters. For panels D–F, an identical analysis was conducted for stress conditions. The dendrogram across conditions in panel D matches that in Fig. 1B. Based on panel E, six yeast strain clusters were identified, and a stronger tendency for wild strain enrichment under stress conditions than nutritional conditions was observed. For panels C and F, the number on each bar indicates the number of yeast strains for each cluster. p-values were calculated using a chi-squared test