Fig. 5

The association between the genotype and the growth phenotype across yeast strains. A A LOD score plot illustrating the association between the genotype and the overall growth phenotype of BY and RM segregants. B, C Manhattan plots depict GWA between the overall growth phenotypes under various nutritional and stress conditions, and the genotypes of different yeast strains. D An error bar plot depicts the network size of the top-ranked genes and the random gene samples with the same number. The x-axis represents the number of genes analyzed, while the y-axis shows the size of the largest connected component in the gene interaction networks. The error bar indicates the standard deviation across 1000 random iterations. E An illustration of the identified network for the 50 highest-ranked genes, which were identified by aggregating p-values from six GWA analyses that examined stress and nutritional conditions across domesticated, wild, and unassigned yeast strains. The thickness of each edge denotes the confidence of the functional association between two genes. The network is visualized using Cytoscape software [37]