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Fig. 2 | BMC Biology

Fig. 2

From: GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer

Fig. 2

Depletion of Gata3 in MMTV-PyMT luminal tumor cells enhances DNA damage in tumorigenesis. a Luminal mammary tumor cells from MMTV-PyMT mice were infected with psi-LVRU6GP-control (sh-Ctrl) or psi-LVRU6GP-Gata3 targeting different sequences of mouse Gata3 (sh-Gata3-a and sh-Gata3-c), selected with puromycin, and analyzed for Gata3 expression. b MMTV-PyMT luminal tumor cells infected with sh-Ctrl and sh-Gata3-c were transplanted into the mammary fat pads (MFPs) of female NCG mice. Tumors formed 8 weeks after transplantation were immunostained with an antibody against γ-H2AX. c The H-scores for γ-H2AX in b were calculated. The results represent the mean ± SD of three individual tumors per group. The asterisk (*) denotes a statistical significance from sh-Ctrl and sh-Gata3-c samples determined by the T-test

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