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  1. Research article

    Amyloid-like aggregation of provasopressin in diabetes insipidus and secretory granule sorting

    Aggregation of peptide hormone precursors in the trans-Golgi network is an essential process in the biogenesis of secretory granules in endocrine cells. It has recently been proposed that this aggregation corr...

    Nicole Beuret, Franziska Hasler, Cristina Prescianotto-Baschong, Julia Birk, Jonas Rutishauser and Martin Spiess

    BMC Biology 2017 15:5

    Published on: 26 January 2017

  2. Research article

    Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion

    Apicomplexan parasites employ a unique form of movement, termed gliding motility, in order to invade the host cell. This movement depends on the parasite’s actomyosin system, which is thought to generate the f...

    Jamie A. Whitelaw, Fernanda Latorre-Barragan, Simon Gras, Gurman S. Pall, Jacqueline M. Leung, Aoife Heaslip, Saskia Egarter, Nicole Andenmatten, Shane R. Nelson, David M. Warshaw, Gary E. Ward and Markus Meissner

    BMC Biology 2017 15:1

    Published on: 18 January 2017

  3. Research article

    Frequency of influenza H3N2 intra-subtype reassortment: attributes and implications of reassortant spread

    Increasing evidence suggests that influenza reassortment not only contributes to the emergence of new human pandemics but also plays an important role in seasonal influenza epidemics, disease severity, evoluti...

    Irina Maljkovic Berry, Melanie C. Melendrez, Tao Li, Anthony W. Hawksworth, Gary T. Brice, Patrick J. Blair, Eric S. Halsey, Maya Williams, Stefan Fernandez, In-Kyu Yoon, Leslie D. Edwards, Robert Kuschner, Xiaoxu Lin, Stephen J. Thomas and Richard G. Jarman

    BMC Biology 2016 14:117

    Published on: 29 December 2016

  4. Comment

    Quantifying western blots: none more black

    Western blotting is among the most common techniques used in molecular biology and a simple way of assessing the presence or absence of a protein. It is also commonly used to compare protein levels in differen...

    Graham Bell

    BMC Biology 2016 14:116

    Published on: 28 December 2016

  5. Question and Answer

    Q&A: what are brassinosteroids and how do they act in plants?

    Brassinosteroids (BRs) are a class of polyhydroxylated steroidal phytohormones in plants with similar structures to animals’ steroid hormones. Brassinosteroids regulate a wide range of physiological processes ...

    Jiao Tang, Zhifu Han and Jijie Chai

    BMC Biology 2016 14:113

    Published on: 22 December 2016

  6. Research article

    The draft genome of whitefly Bemisia tabaci MEAM1, a global crop pest, provides novel insights into virus transmission, host adaptation, and insecticide resistance

    The whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) is among the 100 worst invasive species in the world. As one of the most important crop pests and virus vectors, B. tabaci causes substantial crop losses and p...

    Wenbo Chen, Daniel K. Hasegawa, Navneet Kaur, Adi Kliot, Patricia Valle Pinheiro, Junbo Luan, Marcus C. Stensmyr, Yi Zheng, Wenli Liu, Honghe Sun, Yimin Xu, Yuan Luo, Angela Kruse, Xiaowei Yang, Svetlana Kontsedalov, Galina Lebedev…

    BMC Biology 2016 14:110

    Published on: 14 December 2016

  7. Research article

    Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae

    Transcriptome studies have revealed that many eukaryotic genomes are pervasively transcribed producing numerous long non-coding RNAs (lncRNAs). However, only a few lncRNAs have been ascribed a cellular role th...

    Dimitris Kyriakou, Emmanouil Stavrou, Panayiota Demosthenous, Georgia Angelidou, Bryan-Joseph San Luis, Charles Boone, Vasilis J. Promponas and Antonis Kirmizis

    BMC Biology 2016 14:106

    Published on: 7 December 2016

  8. Research article

    The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C

    Mutations in Lipopolysaccharide-induced tumour necrosis factor-α factor (LITAF) cause the autosomal dominant inherited peripheral neuropathy, Charcot-Marie-Tooth disease type 1C (CMT1C). LITAF encodes a 17 kDa pr...

    Anita K. Ho, Jane L. Wagstaff, Paul T. Manna, Lena Wartosch, Seema Qamar, Elspeth F. Garman, Stefan M. V. Freund and Rhys C. Roberts

    BMC Biology 2016 14:109

    Published on: 7 December 2016

  9. Research article

    Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice

    Palmitoylation, the addition of palmitate to proteins by palmitoyl acyltransferases (PATs), is an important regulator of synaptic protein localization and function. Many palmitoylated proteins and PATs have be...

    Shaun S. Sanders, Matthew P. Parsons, Katherine K. N. Mui, Amber L. Southwell, Sonia Franciosi, Daphne Cheung, Sabine Waltl, Lynn A. Raymond and Michael R. Hayden

    BMC Biology 2016 14:108

    Published on: 7 December 2016

  10. Research article

    Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development

    Tribbles proteins are conserved pseudokinases that function to control kinase signalling and transcription in diverse biological processes. Abnormal function in human Tribbles has been implicated in a number o...

    Kyung Won Kim, Nishant Thakur, Christopher A. Piggott, Shizue Omi, Jolanta Polanowska, Yishi Jin and Nathalie Pujol

    BMC Biology 2016 14:104

    Published on: 7 December 2016

  11. Research article

    Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders

    Defects in genes involved in mitochondrial fatty-acid oxidation (mFAO) reduce the ability of patients to cope with metabolic challenges. mFAO enzymes accept multiple substrates of different chain length, leadi...

    Karen van Eunen, Catharina M. L. Volker-Touw, Albert Gerding, Aycha Bleeker, Justina C. Wolters, Willemijn J. van Rijt, Anne-Claire M. F. Martines, Klary E. Niezen-Koning, Rebecca M. Heiner, Hjalmar Permentier, Albert K. Groen, Dirk-Jan Reijngoud, Terry G. J. Derks and Barbara M. Bakker

    BMC Biology 2016 14:107

    Published on: 7 December 2016

  12. Research article

    Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway

    Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis, whic...

    Deborah L. McEwan, Rhonda L. Feinbaum, Nicholas Stroustrup, Wilhelm Haas, Annie L. Conery, Anthony Anselmo, Ruslan Sadreyev and Frederick M. Ausubel

    BMC Biology 2016 14:105

    Published on: 7 December 2016

  13. Research article

    Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins

    The specificity of synaptic connections is fundamental for proper neural circuit function. Specific neuronal connections that underlie information processing in the sensory cortex are initially established wit...

    Etsuko Tarusawa, Makoto Sanbo, Atsushi Okayama, Toshio Miyashita, Takashi Kitsukawa, Teruyoshi Hirayama, Takahiro Hirabayashi, Sonoko Hasegawa, Ryosuke Kaneko, Shunsuke Toyoda, Toshihiro Kobayashi, Megumi Kato-Itoh, Hiromitsu Nakauchi, Masumi Hirabayashi, Takeshi Yagi and Yumiko Yoshimura

    BMC Biology 2016 14:103

    Published on: 2 December 2016

  14. Commentary

    The Year of the Wisent

    Delving into European prehistory, two recent studies analyze ancient DNA from bison species depicted by our ancestors on the walls of their caves. The DNA tells a story of migrations driven by climate change b...

    Johannes A. Lenstra and Jianquan Liu

    BMC Biology 2016 14:100

    Published on: 18 November 2016

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