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  1. Question and Answer

    Q&A: what are brassinosteroids and how do they act in plants?

    Brassinosteroids (BRs) are a class of polyhydroxylated steroidal phytohormones in plants with similar structures to animals’ steroid hormones. Brassinosteroids regulate a wide range of physiological processes ...

    Jiao Tang, Zhifu Han and Jijie Chai

    BMC Biology 2016 14:113

    Published on: 22 December 2016

  2. Research article

    The draft genome of whitefly Bemisia tabaci MEAM1, a global crop pest, provides novel insights into virus transmission, host adaptation, and insecticide resistance

    The whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) is among the 100 worst invasive species in the world. As one of the most important crop pests and virus vectors, B. tabaci causes substantial crop losses and p...

    Wenbo Chen, Daniel K. Hasegawa, Navneet Kaur, Adi Kliot, Patricia Valle Pinheiro, Junbo Luan, Marcus C. Stensmyr, Yi Zheng, Wenli Liu, Honghe Sun, Yimin Xu, Yuan Luo, Angela Kruse, Xiaowei Yang, Svetlana Kontsedalov, Galina Lebedev…

    BMC Biology 2016 14:110

    Published on: 14 December 2016

  3. Research article

    Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae

    Transcriptome studies have revealed that many eukaryotic genomes are pervasively transcribed producing numerous long non-coding RNAs (lncRNAs). However, only a few lncRNAs have been ascribed a cellular role th...

    Dimitris Kyriakou, Emmanouil Stavrou, Panayiota Demosthenous, Georgia Angelidou, Bryan-Joseph San Luis, Charles Boone, Vasilis J. Promponas and Antonis Kirmizis

    BMC Biology 2016 14:106

    Published on: 7 December 2016

  4. Research article

    The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C

    Mutations in Lipopolysaccharide-induced tumour necrosis factor-α factor (LITAF) cause the autosomal dominant inherited peripheral neuropathy, Charcot-Marie-Tooth disease type 1C (CMT1C). LITAF encodes a 17 kDa pr...

    Anita K. Ho, Jane L. Wagstaff, Paul T. Manna, Lena Wartosch, Seema Qamar, Elspeth F. Garman, Stefan M. V. Freund and Rhys C. Roberts

    BMC Biology 2016 14:109

    Published on: 7 December 2016

  5. Research article

    Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice

    Palmitoylation, the addition of palmitate to proteins by palmitoyl acyltransferases (PATs), is an important regulator of synaptic protein localization and function. Many palmitoylated proteins and PATs have be...

    Shaun S. Sanders, Matthew P. Parsons, Katherine K. N. Mui, Amber L. Southwell, Sonia Franciosi, Daphne Cheung, Sabine Waltl, Lynn A. Raymond and Michael R. Hayden

    BMC Biology 2016 14:108

    Published on: 7 December 2016

  6. Research article

    Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development

    Tribbles proteins are conserved pseudokinases that function to control kinase signalling and transcription in diverse biological processes. Abnormal function in human Tribbles has been implicated in a number o...

    Kyung Won Kim, Nishant Thakur, Christopher A. Piggott, Shizue Omi, Jolanta Polanowska, Yishi Jin and Nathalie Pujol

    BMC Biology 2016 14:104

    Published on: 7 December 2016

  7. Research article

    Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders

    Defects in genes involved in mitochondrial fatty-acid oxidation (mFAO) reduce the ability of patients to cope with metabolic challenges. mFAO enzymes accept multiple substrates of different chain length, leadi...

    Karen van Eunen, Catharina M. L. Volker-Touw, Albert Gerding, Aycha Bleeker, Justina C. Wolters, Willemijn J. van Rijt, Anne-Claire M. F. Martines, Klary E. Niezen-Koning, Rebecca M. Heiner, Hjalmar Permentier, Albert K. Groen, Dirk-Jan Reijngoud, Terry G. J. Derks and Barbara M. Bakker

    BMC Biology 2016 14:107

    Published on: 7 December 2016

  8. Research article

    Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway

    Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis, whic...

    Deborah L. McEwan, Rhonda L. Feinbaum, Nicholas Stroustrup, Wilhelm Haas, Annie L. Conery, Anthony Anselmo, Ruslan Sadreyev and Frederick M. Ausubel

    BMC Biology 2016 14:105

    Published on: 7 December 2016

  9. Research article

    Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins

    The specificity of synaptic connections is fundamental for proper neural circuit function. Specific neuronal connections that underlie information processing in the sensory cortex are initially established wit...

    Etsuko Tarusawa, Makoto Sanbo, Atsushi Okayama, Toshio Miyashita, Takashi Kitsukawa, Teruyoshi Hirayama, Takahiro Hirabayashi, Sonoko Hasegawa, Ryosuke Kaneko, Shunsuke Toyoda, Toshihiro Kobayashi, Megumi Kato-Itoh, Hiromitsu Nakauchi, Masumi Hirabayashi, Takeshi Yagi and Yumiko Yoshimura

    BMC Biology 2016 14:103

    Published on: 2 December 2016

  10. Commentary

    The Year of the Wisent

    Delving into European prehistory, two recent studies analyze ancient DNA from bison species depicted by our ancestors on the walls of their caves. The DNA tells a story of migrations driven by climate change b...

    Johannes A. Lenstra and Jianquan Liu

    BMC Biology 2016 14:100

    Published on: 18 November 2016

  11. Question and Answer

    The evolving world of pseudoenzymes: proteins, prejudice and zombies

    Pseudoenzymes are catalytically deficient variants of enzymes that are represented in all major enzyme families. Their regulatory functions in signalling pathways are shedding new light on the non-catalytic fu...

    Patrick A. Eyers and James M. Murphy

    BMC Biology 2016 14:98

    Published on: 11 November 2016

  12. Research article

    Genetic impairment of parasite myosin motors uncovers the contribution of host cell membrane dynamics to Toxoplasma invasion forces

    The several-micrometer-sized Toxoplasma gondii protozoan parasite invades virtually any type of nucleated cell from a warm-blooded animal within seconds. Toxoplasma initiates the formation of a tight ring-like ju...

    Marion Bichet, Bastien Touquet, Virginie Gonzalez, Isabelle Florent, Markus Meissner and Isabelle Tardieux

    BMC Biology 2016 14:97

    Published on: 9 November 2016

  13. Research article

    Predicting Wolbachia invasion dynamics in Aedes aegypti populations using models of density-dependent demographic traits

    Arbovirus transmission by the mosquito Aedes aegypti can be reduced by the introduction and establishment of the endosymbiotic bacteria Wolbachia in wild populations of the vector. Wolbachia spreads by increasing...

    Penelope A. Hancock, Vanessa L. White, Scott A. Ritchie, Ary A. Hoffmann and H. Charles J. Godfray

    BMC Biology 2016 14:96

    Published on: 8 November 2016

  14. Research article

    TIS7 induces transcriptional cascade of methylosome components required for muscle differentiation

    TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that ...

    Andrea Lammirato, Katherin Patsch, Fabien Feiereisen, Karl Maly, Charity Nofziger, Markus Paulmichl, Hubert Hackl, Zlatko Trajanoski, Taras Valovka, Lukas A. Huber and Ilja Vietor

    BMC Biology 2016 14:95

    Published on: 25 October 2016

  15. Research article

    Past climate changes, population dynamics and the origin of Bison in Europe

    Climatic and environmental fluctuations as well as anthropogenic pressure have led to the extinction of much of Europe’s megafauna. The European bison or wisent (Bison bonasus), one of the last wild European larg...

    Diyendo Massilani, Silvia Guimaraes, Jean-Philip Brugal, E. Andrew Bennett, Malgorzata Tokarska, Rose-Marie Arbogast, Gennady Baryshnikov, Gennady Boeskorov, Jean-Christophe Castel, Sergey Davydov, Stéphane Madelaine, Olivier Putelat, Natalia N. Spasskaya, Hans-Peter Uerpmann, Thierry Grange and Eva-Maria Geigl

    BMC Biology 2016 14:93

    Published on: 21 October 2016

  16. Comment

    Open questions: how does Wolbachia do what it does?

    A common symbiont of insects, the bacterium Wolbachia has been implicated in phenomena as diverse as sex determination, pathogen defence and speciation and is being used in public health programs to prevent mosqu...

    Francis M. Jiggins

    BMC Biology 2016 14:92

    Published on: 19 October 2016

  17. Research article

    Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia

    Relapsed acute lymphoblastic leukemia (ALL) is one of the main causes of mortality in childhood malignancies. Previous genetic studies demonstrated that chemoresistant ALL is driven by activating mutations in NT5...

    Aleš Hnízda, Jana Škerlová, Milan Fábry, Petr Pachl, Martina Šinalová, Lukáš Vrzal, Petr Man, Petr Novák, Pavlína Řezáčová and Václav Veverka

    BMC Biology 2016 14:91

    Published on: 19 October 2016

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