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  1. Research article

    Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors

    Plant-pathogenic oomycetes are responsible for economically important losses in crops worldwide. Phytophthora palmivora, a tropical relative of the potato late blight pathogen, causes rotting diseases in many tro...

    Edouard Evangelisti, Anna Gogleva, Thomas Hainaux, Mehdi Doumane, Frej Tulin, Clément Quan, Temur Yunusov, Kévin Floch and Sebastian Schornack

    BMC Biology 2017 15:39

    Published on: 11 May 2017

  2. Research article

    Heterosis as a consequence of regulatory incompatibility

    The merging of genomes in inter-specific hybrids can result in novel phenotypes, including increased growth rate and biomass yield, a phenomenon known as heterosis. Heterosis is typically viewed as the opposit...

    Rebecca H. Herbst, Dana Bar-Zvi, Sharon Reikhav, Ilya Soifer, Michal Breker, Ghil Jona, Eyal Shimoni, Maya Schuldiner, Avraham A. Levy and Naama Barkai

    BMC Biology 2017 15:38

    Published on: 11 May 2017

  3. Comment

    Can a biologist fix a smartphone?—Just hack it!

    Biological systems integrate multiscale processes and networks and are, therefore, viewed as difficult to dissect. However, because of the clear-cut separation between the software code (the information encode...

    Sophien Kamoun

    BMC Biology 2017 15:37

    Published on: 8 May 2017

  4. Research article

    Central peptidergic modulation of peripheral olfactory responses

    Animal olfactory systems detect volatile environmental chemicals and integrate this information to direct the discovery of food and mates as well as danger avoidance. Rather than remaining constant, olfactory ...

    Sion Lee, Young-Joon Kim and Walton D. Jones

    BMC Biology 2017 15:35

    Published on: 5 May 2017

  5. Review

    The biological function of the cellular prion protein: an update

    The misfolding of the cellular prion protein (PrPC) causes fatal neurodegenerative diseases. Yet PrPC is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary eli...

    Marie-Angela Wulf, Assunta Senatore and Adriano Aguzzi

    BMC Biology 2017 15:34

    Published on: 2 May 2017

  6. Research article

    Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel

    Trimeric intracellular cation (TRIC) channels are crucial for Ca2+ handling in eukaryotes and are involved in K+ uptake in prokaryotes. Recent studies on the representative members of eukaryotic and prokaryotic T...

    Xiaomin Ou, Jianli Guo, Longfei Wang, Hanting Yang, Xiuying Liu, Jianyuan Sun and Zhenfeng Liu

    BMC Biology 2017 15:31

    Published on: 22 April 2017

  7. Research article

    Single swim sessions in C. elegans induce key features of mammalian exercise

    Exercise exerts remarkably powerful effects on metabolism and health, with anti-disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits might improve the health of the sedent...

    Ricardo Laranjeiro, Girish Harinath, Daniel Burke, Bart P. Braeckman and Monica Driscoll

    BMC Biology 2017 15:30

    Published on: 10 April 2017

  8. Research article

    OsLG3 contributing to rice grain length and yield was mined by Ho-LAMap

    Most agronomic traits in rice are complex and polygenic. The identification of quantitative trait loci (QTL) for grain length is an important objective of rice genetic research and breeding programs.

    Jianping Yu, Haiyan Xiong, Xiaoyang Zhu, Hongliang Zhang, Huihui Li, Jinli Miao, Wensheng Wang, Zuoshun Tang, Zhanying Zhang, Guoxin Yao, Qiang Zhang, Yinghua Pan, Xin Wang, M. A. R. Rashid, Jinjie Li, Yongming Gao…

    BMC Biology 2017 15:28

    Published on: 6 April 2017

  9. Methodology article

    A multi-animal tracker for studying complex behaviors

    Animals exhibit astonishingly complex behaviors. Studying the subtle features of these behaviors requires quantitative, high-throughput, and accurate systems that can cope with the often rich perplexing data.

    Eyal Itskovits, Amir Levine, Ehud Cohen and Alon Zaslaver

    BMC Biology 2017 15:29

    Published on: 6 April 2017

  10. Research article

    Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum

    Mitochondria of opisthokonts undergo permanent fission and fusion throughout the cell cycle. Here, we investigated the dynamics of the mitosomes, the simplest forms of mitochondria, in the anaerobic protist pa...

    Luboš Voleman, Vladimíra Najdrová, Ásgeir Ástvaldsson, Pavla Tůmová, Elin Einarsson, Zdeněk Švindrych, Guy M. Hagen, Jan Tachezy, Staffan G. Svärd and Pavel Doležal

    BMC Biology 2017 15:27

    Published on: 3 April 2017

  11. Research article

    TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2

    The fate of hydrogen peroxide (H2O2) in the endoplasmic reticulum (ER) has been inferred indirectly from the activity of ER-localized thiol oxidases and peroxiredoxins, in vitro, and the consequences of their gen...

    Eduardo Pinho Melo, Carlos Lopes, Peter Gollwitzer, Stephan Lortz, Sigurd Lenzen, Ilir Mehmeti, Clemens F. Kaminski, David Ron and Edward Avezov

    BMC Biology 2017 15:24

    Published on: 27 March 2017

  12. Research article

    Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes

    Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the function of the d...

    Estefania Tarifeño-Saldivia, Arnaud Lavergne, Alice Bernard, Keerthana Padamata, David Bergemann, Marianne L. Voz, Isabelle Manfroid and Bernard Peers

    BMC Biology 2017 15:21

    Published on: 21 March 2017

  13. Methodology article

    Low-cell-number, single-tube amplification (STA) of total RNA revealed transcriptome changes from pluripotency to endothelium

    In addition to messenger RNA (mRNA), noncoding RNAs (ncRNAs) are essential components in cellular machineries for translation and splicing. Besides their housekeeping functions, ncRNAs are involved in cell typ...

    Yi-Hsuan Lee, Ya-Wen Hsueh, Yao-Hung Peng, Kung-Chao Chang, Kuen-Jer Tsai, H. Sunny Sun, Ih-Jen Su and Po-Min Chiang

    BMC Biology 2017 15:22

    Published on: 21 March 2017

  14. Research article

    Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana

    Plants are exposed to diverse pathogens and pests, yet most plants are resistant to most plant pathogens. Non-host resistance describes the ability of all members of a plant species to successfully prevent col...

    David C. Prince, Ghanasyam Rallapalli, Deyang Xu, Henk-jan Schoonbeek, Volkan Çevik, Shuta Asai, Eric Kemen, Neftaly Cruz-Mireles, Ariane Kemen, Khaoula Belhaj, Sebastian Schornack, Sophien Kamoun, Eric B. Holub, Barbara A. Halkier and Jonathan D. G. Jones

    BMC Biology 2017 15:20

    Published on: 20 March 2017

  15. Commentary

    The important challenge of quantifying tropical diversity

    The tropics are the repository of much of the world’s biodiversity, yet are undersampled relative to temperate regions. To help fill this knowledge gap, a paper in BMC Biology explores diversity patterns in tropi...

    Anne E. Magurran

    BMC Biology 2017 15:14

    Published on: 7 March 2017

  16. Research article

    Exploring the floristic diversity of tropical Africa

    Understanding the patterns of biodiversity distribution and what influences them is a fundamental pre-requisite for effective conservation and sustainable utilisation of biodiversity. Such knowledge is increas...

    Marc S. M. Sosef, Gilles Dauby, Anne Blach-Overgaard, Xander van der Burgt, Luís Catarino, Theo Damen, Vincent Deblauwe, Steven Dessein, John Dransfield, Vincent Droissart, Maria Cristina Duarte, Henry Engledow, Geoffrey Fadeur, Rui Figueira, Roy E. Gereau, Olivier J. Hardy…

    BMC Biology 2017 15:15

    Published on: 7 March 2017

  17. Research article

    Structural basis for potency differences between GDF8 and GDF11

    Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a negative regulator of muscle growth and di...

    Ryan G. Walker, Magdalena Czepnik, Erich J. Goebel, Jason C. McCoy, Ana Vujic, Miook Cho, Juhyun Oh, Senem Aykul, Kelly L. Walton, Gauthier Schang, Daniel J. Bernard, Andrew P. Hinck, Craig A. Harrison, Erik Martinez-Hackert, Amy J. Wagers, Richard T. Lee…

    BMC Biology 2017 15:19

    Published on: 3 March 2017

  18. Review

    Meta-evaluation of meta-analysis: ten appraisal questions for biologists

    Meta-analysis is a statistical procedure for analyzing the combined data from different studies, and can be a major source of concise up-to-date information. The overall conclusions of a meta-analysis, however...

    Shinichi Nakagawa, Daniel W. A. Noble, Alistair M. Senior and Malgorzata Lagisz

    BMC Biology 2017 15:18

    Published on: 3 March 2017

  19. Research article

    Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vector

    The mosquito Aedes aegypti is the main vector of dengue, Zika, chikungunya and yellow fever viruses. This major disease vector is thought to have arisen when the African subspecies Ae. aegypti formosus evolved fr...

    Jacob E. Crawford, Joel M. Alves, William J. Palmer, Jonathan P. Day, Massamba Sylla, Ranjan Ramasamy, Sinnathamby N. Surendran, William C. Black IV, Arnab Pain and Francis M. Jiggins

    BMC Biology 2017 15:16

    Published on: 28 February 2017

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