Figure 7
From: Astrocytes convert network excitation to tonic inhibition of neurons
Effect of t-PDC and SNAP-5114 on the gamma band activity in the CA1 region of rats under ketamine/xylazine anaesthesia. (A) Left: Nissl stained section of the injector electrode penetration track. The vertical black line represents the track. Scale bar is 1 mm. Right: single sweep CSD activity from the str. pyramidale to the thalamus during high amplitude gamma activity in the hippocampus. Injection site was located between CSD channel 4 and 5. CSD values are in arbitrary units, time and amplitude calibration is 300 ms and 1024 μV respectively. (B) Effect of t-PDC (1 mM) on the CA1 str. radiatum CSD power compared to the pre-injection control. Black line with asterisk marks significant (P < 0.005) CSD power increase after t-PDC application. Power is normalized to the peak power of the control in the gamma (30 to 80 Hz) range. (C) Effect of simultaneous application of t-PDC (1 mM) and SNAP-5114 (1 mM) mixture on the CA1 str. radiatum CSD power compared to the pre-injection control. Black line with asterisk marks significant (P < 0.005) CSD power drop after t-PDC and SNAP-5114 application. (D) Effect of the saline solution containing 1% DMSO on the CA1 str. radiatum CSD power compared to the pre-injection control. No significant CSD power change was detected in the gamma range.