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Sculpting membranes

A model based on molecular dynamics simulations portrays ESCRT-III as a multifilament assembly of beads connected by springs, capable of driving the full range of experimentally reported ESCRT-III dependent membrane remodelling.

Understanding Sperm-Oocyte interactions

Brett Nixon, Moira O’Bryan and colleagues identify mouse spermatozoa proteins that participate in oolemma interactions through multimeric protein complexes, and are required for optimal fertilisation.

Going viral in the gut

Zhernakova and colleagues discuss the viral component of the gut ecosystem, the challenges of studying the bacteriophages that shape our gut microbiomes, and what we know so far of their role in health and disease.

A beneficial family of bacteria

Jillian Waters and Ruth Ley review what we have learned about the Christensenellaceae, a recently-discovered family of gut bacteria that is widespread, heritable, and significantly associated with human health.

The developmental cell lineage of the annelid brain

Spiral cleavage patterns produce radially arranged blastomeres, but spiralian larvae later metamorphose into fully bilateral juveniles. The cell lineage of the Platynereis larval episphere may help reveal how bilateral symmetry of the head emerges.

The Evolution of Regeneration

Ramon-Mateu and colleagues use the comb jelly as a model to show that cell proliferation is required for regeneration in ctenophores, but is separable from wound healing; and might shed light on regenerative diversity among metazoans.

Featured Review

Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches

Shoval Lagziel, Won Dong Lee & Tomer Shlomi

Published on: 04 July 2019

Articles

Research
Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico
Lena Harker-Kirschneck, Buzz Baum & And̄ela Šarić
Published on: 22 October 2019

Research
From spiral cleavage to bilateral symmetry: the developmental cell lineage of the annelid brain
Pavel Vopalensky, Maria Antonietta Tosches, Kaia Achim, Mette Handberg-Thorsager & Detlev Arendt 
Published on: 22 October 2019

Research
Regeneration in the ctenophore Mnemiopsis leidyioccurs in the absence of a blastema, requires cell division, and is temporally separable from wound healing
Julia Ramon-Mateu, S. Tori Ellison, Thomas E. Angelini & Mark Q. Martindale
Published on: 11 October 2019

Research
Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the wasp Nasonia vitripennis
Honghu Quan, Deanna Arsala & Jeremy A. Lynch
Published on: 10 October 2019

Research
Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study
Matthias Willmann, Maria J. G. T. Vehreschild, Lena M. Biehl, Wichard Vogel, Daniela Dörfel, Axel Hamprecht, Harald Seifert, Ingo B. Autenrieth & Silke Peter
Published on: 18 September 2019

Question & Answer
Bacterial microcompartments: catalysis-enhancing metabolic modules for next generation metabolic and biomedical engineering
Henning Kirst & Cheryl A. Kerfeld 
Published on: 10 October 2019

Review
Genetic voltage indicators
Yuki Bando, Christiane Grimm, Victor H Cornejo & Rafael Yuste
Published on: 12 September 2019

Review
Synthetic Biology Goes Cell-Free
Aidan Tinafar, Katariina Jaenes & Keith Pardee
Pubished on: 8 August 2019

Review
Viral hijacking of cellular metabolism
Shivani K. Thaker, James Ch’ng & Heather R. Christofk
Published on: 18 July 2019

Comment
Multiple levels of the unknown in microbiome research
Andrew Maltez Thomas & Nicola Segata 
Published on: 12 June 2019

  1. Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

    Content type: Research article

Focus: Complex Data Analysis in Health and Disease

Read the latest papers on Complex Data Analysis across BMC flagship journals.

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
Bahram Namjou et al.

Published in BMC Medicine 17 July 2019

Detecting neural assemblies in calcium imaging data
Jan Mölter, Lilach Avitan & Geoffrey J. Goodhill

Published in BMC Biology 28 November 2018

Exploring the OncoGenomic Landscape of cancer
Lidia Mateo et al.

Published in Genome Medicine 03 August 2018

Measuring the reproducibility and quality of Hi-C data
Galip Gürkan Yardımcı et al.

Published in Genome Biology 19 March 2019

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