BMC Biology

Identification of Cell Types in a Mouse Brain

Arnold Kriegstein and Apharna Badhuri show that analysis of 50.000 cells can recapitulate the structure of a 1.3 million cell RNAseq mouse brain atlas, suggesting that profiling more individuals at low cell resolution may be beneficial for atlas-scale studies

Open Questions: What Constitutes an Individual?

Our Editorial Board Member Robin Weiss considers how unique examples from nature such as chimeric animals and transmissible cancer cells inform us on the nature of individuality in multicellular organisms

Post-Translational Modifications Driving Platelet Formation

Nathalie Morin and colleagues show that polyglutamylation and acetylation of microtubules drive the morphological changes happening during proplatelet maturation, critical for platelet release and function

Call for Papers – Special Issue on Cancer Metabolism

We are now inviting submissions of Research papers for our cross-journal special issue. Guest Editors: Navdeep Chandel, Matthew Vander Heiden, Karen Vousden and Kathryn Wellen; submission deadline - December 1^st 2018. Read more here!

Call for Papers: Microbiome Biology

BMC Biology and Genome Biology are inviting submission for their upcoming joint special issue on Microbiome Biology scheduled for publication in Spring 2019

A Mechanism for H3.3 Recognition and Deposition

In their new paper, Guohong Li and colleagues identify the mechanism through which the HIRA complex specifically recognizes and deposits H3.3 at promoters and enhancers of developmental genes, affecting neural differentiation

Articles

Content type: Research article
| 18 October 2018

Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation

Authors: Juliette van Dijk, Guillaume Bompard, Julien Cau, Shinji Kunishima, Gabriel Rabeharivelo, Julio Mateos-Langerak, Chantal Cazevieille, Patricia Cavelier, Brigitte Boizet-Bonhoure, Claude Delsert and Nathalie Morin
Content type: Comment
| 15 October 2018

Open questions: knowing who’s who in multicellular animals is not always as simple as we imagine

Authors: Robin A. Weiss
Content type: Research article
| 11 October 2018

Identification of cell types in a mouse brain single-cell atlas using low sampling coverage

Authors: Aparna Bhaduri, Tomasz J Nowakowski, Alex A Pollen and Arnold R Kriegstein
Content type: Research article
| 8 October 2018

Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans

Authors: Rebecca E. W. Kaplan, Amy K. Webster, Rojin Chitrakar, Joseph A. Dent and L. Ryan Baugh
Content type: Research article
| 3 October 2018

UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells

Authors: Chaoyang Xiong, Zengqi Wen, Juan Yu, Jun Chen, Chao-Pei Liu, Xiaodong Zhang, Ping Chen, Rui-Ming Xu and Guohong Li

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Research
Loss of males from mixed-sex societies in termites
Toshihisa Yashiro, Nathan Lo, Kazuya Kobayashi, Tomonari Nozaki, Taro Fuchikawa, Nobuaki Mizumoto, Yusuke Namba and Kenji Matsuura
Published on: 25 September 2018

Research
Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes
Pauline Salis, Natacha Roux, Olivier Soulat, David Lecchini, Vincent Laudet and Bruno Frédérich
Published on: 05 September 2018

Research
Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development
P. J. Fabre, M. Leleu, B. Mascrez, Q. Lo Giudice, J. Cobb and D. Duboule
Published on: 18 September 2018

Methodology
Cell fixation and preservation for droplet-based single-cell transcriptomics
Jonathan Alles, Nikos Karaiskos, Samantha D. Praktiknjo, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks and Nikolaus Rajewsky
Published on: 19 May 2017

Research
Cell type-specific expression profiling unravels the development and evolution of stinging cells in sea anemone
Kartik Sunagar, Yaara Y Columbus-Shenkar, Arie Fridrich, Nadya Gutkovich, Reuven Aharoni and Yehu Moran
Published on: 27 September 2018

Open Questions
Open questions: How many genes do we have?
Steven L. Salzberg
Published on: 20 August 2018

Open Questions
Open questions: CRISPR biology
Eugene V. Koonin
Published on: 24 September 2018

Review
Horizons in the evolution of aging
Thomas Flatt and Linda Partridge
Published on: 20 August 2018

Commentary
The disposable male— the ultimate emancipation of females?
Duur K. Aanen
Published on: 25 September 2018

Review
Tissue macrophages: heterogeneity and functions
Siamon Gordon and Annette Plüddemann
Published on: 29 June 2017

Content type: Research article
| 24 September 2009

scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Authors: Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson and Anthony M Brumby
Content type: Review
| 28 October 2011

Molecular dynamics simulations and drug discovery

Authors: Jacob D Durrant and J Andrew McCammon
Content type: Question and Answer
| 30 September 2011

Q&A: What is the Golgi apparatus, and why are we asking?

Authors: Sean Munro
Content type: Research article
| 23 November 2009

Mapping cortical hubs in tinnitus

Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz
Content type: Forum
| 14 December 2012

What determines cell size?

Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

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Focus: the Microbiome

Read the latest Reviews on microbiomes across BMC flagship journals.

The gut microbiome in human immunodeficiency virus infection
Gili Zilberman-Schapira, Niv Zmora, Shlomik Itav, Stavros Bashiardes, Hila Elinav and Eran Elinav
Published in BMC Medicine on: 3 June 2016

The human microbiome in evolution
Emily R. Davenport, Jon G. Sanders, Se Jin Song, Katherine R. Amato, Andrew G. Clark and Rob Knight
Published in BMC Biology on: 27 December2017

The healthy human microbiome
Jason Lloyd-Price, Galeb Abu-Ali and Curtis Huttenhower
Published in Genome Medicine on: 27 April 2016

Experimental design and quantitative analysis of microbial community multiomics
Jason Lloyd-Price, Galeb Abu-Ali and Curtis Huttenhower Himel Mallick, Siyuan Ma, Eric A. Franzosa, Tommi Vatanen, Xochitl C. Morgan and Curtis Huttenhower
Published in Genome Biology on: 30 November 2017