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A Roundabout Way to Folate Supplementation

David Weinkove and colleagues show that the effectiveness of folic acid supplementation in C. elegans  depends on gut microbes which use folate breakdown products to increase their own folate synthesis, impacting C. elegans development and longevity

How Muscle Metabolism Copes with Energetic Challenges

Francois Favier and colleagues show that REDD1 reduces O2 and ATP consumption in muscles by acting on mitochondrial-associated endoplasmic reticulum membranes and the signaling pathways they support

Membrane Dynamics Get Peculiar

A comprehensive ultrastructural analysis of mitotic Drosophila S2 cells by Maurizio Gatti, Anton Strunov and colleagues identifies their unique features, including novel intracellular membranes’ structures and spindle organization

Rapid High-resolution Imaging of Large Biological Samples

Light Sheet Theta Microscopy, developed by Raju Tomer and colleagues allows rapid, high-resolution imaging of large samples, such as human brain slices, expanded tissues, or highly motile animals like the Hydra

Improving the Fidelity of Organoid Cell Types via Single-Cell Genomics

Jeff Karp, Benjamin Mead and colleagues use systematic single-cell analysis to generate organoid-derived intestinal cells, demonstrating a rational approach to creating faithful models of in vivo populations

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Stay up to date with our authoritative Reviews from leaders in the field, on topics including the microbiome, cancer, evolution, neurobiology, cell biology and genetics

Featured Forum

Membrane dynamics and organelle biogenesis—lipid pipelines and vesicular carriers

Christopher J. Stefan, William S. Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M. Valm, Jennifer Lippincott-Schwartz, Tim P. Levine, David B. Iaea, Frederick R. Maxfield, Clare E. Futter, Emily R. Eden, Delphine Judith, Alexander R. van Vliet, Patrizia Agostinis, Sharon A. Tooze, Ayumu Sugiura and Heidi M. McBride

Published on: 31 October 2017




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Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
Benjamin E. Mead, Jose Ordovas-Montanes, Alexandra P. Braun, Lauren E. Levy, Prerna Bhargava, Matthew J. Szucs, Dustin A. Ammendolia, Melanie A. MacMullan, Xiaolei Yin, Travis K. Hughes, Marc H. WadsworthII, Rushdy Ahmad, Seth Rakoff-Nahoum, Steven A. Carr, Robert Langer, James J. Collins, Alex K. Shalek and Jeffrey M. Karp
Published on: 5 June 2017

Light sheet theta microscopy for rapid high-resolution imaging of large biological samples
JonatBianca Migliori, Malika S. Datta, Christophe Dupre, Mehmet C. Apak, Shoh Asano, Ruixuan Gao, Edward S. Boyden, Ola Hermanson, Rafael Yuste and Raju Tomer
Published on: 29 May 2017

Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography
Jose L. Olmos Jr, Suraj Pandey, Jose M. Martin-Garcia, George Calvey, Andrea Katz, Juraj Knoska, Christopher Kupitz, Mark S. Hunter, Mengning Liang, Dominik Oberthuer, Oleksandr Yefanov, Max Wiedorn, Michael Heyman, Mark Holl, Kanupriya Pande, Anton Barty, Mitchell D. Miller, Stephan Stern, Shatabdi Roy-Chowdhury, Jesse Coe, Nirupa Nagaratnam, James Zook, Jacob Verburgt, Tyler Norwood, Ishwor Poudyal, David Xu, Jason Koglin, Matthew H. Seaberg, Yun Zhao, Saša Bajt, Thomas Grant, Valerio Mariani, Garrett Nelson, Ganesh Subramanian, Euiyoung Bae, Raimund Fromme, Russell Fung, Peter Schwander, Matthias Frank, Thomas A. White, Uwe Weierstall, Nadia Zatsepin, John Spence, Petra Fromme, Henry N. Chapman, Lois Pollack, Lee Tremblay, Abbas Ourmazd, George N. Phillips Jr and Marius Schmidt
Published on: 31 May 2018

Comparative genomics of the miniature wasp and pest control agent Trichogramma pretiosum
Amelia R. I. Lindsey, Yogeshwar D. Kelkar, Xin Wu, Dan Sun, Ellen O. Martinson, Zhichao Yan, Paul F. Rugman-Jones, Daniel S. T. Hughes, Shwetha C. Murali, Jiaxin Qu, Shannon Dugan, Sandra L. Lee, Hsu Chao, Huyen Dinh, Yi Han, Harsha Vardhan Doddapaneni…
Published on: 18 May 2018

Small RNA profiling of low biomass samples: identification and removal of contaminants
Anna Heintz-Buschart, Dilmurat Yusuf, Anne Kaysen, Alton Etheridge, Joëlle V. Fritz, Patrick May, Carine de Beaufort, Bimal B. Upadhyaya, Anubrata Ghosal, David J. Galas and Paul Wilmes
Published on: 14 May 2018

The biological function of the cellular prion protein: an update
Marie-Angela Wulf, Assunta Senatore and Adriano Aguzzi
Published on: 2 May 2017

Non-model model organisms
James J. Russell, Julie A. TheriotEmail author, Pranidhi Sood, Wallace F. MarshallEmail author, Laura F. Landweber, Lillian Fritz-Laylin, Jessica K. Polka, Snezhana Oliferenko, Therese Gerbich, Amy Gladfelter, James Umen, Magdalena Bezanilla, Madeline A. Lancaster, Shuonan He, Matthew C. Gibson, Bob Goldstein, Elly M. Tanaka, Chi-Kuo Hu and Anne Brunet
Published on: 29 June 2017

Meta-evaluation of meta-analysis: ten appraisal questions for biologists
Shinichi Nakagawa, Daniel W. A. Noble, Alistair M. Senior and Malgorzata Lagisz
Published on: 3 March 2017

Towards a Dynamic Interaction Network of Life to unify and expand the evolutionary theory
Eric Bapteste and Philippe Huneman
Published on: 29 May 2018

Antibiotic resistance: it’s bad, but why isn’t it worse?
Nicholas Waglechner and Gerard D. Wright
Published on: 15 September 2017

  1. Content type: Research article


    Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

  2. Content type: Forum


    Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

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