BMC Biology

Hoxd Signatures in Limb Development

Pierre Fabre, Denis Duboule and colleagues show heterogeneous and combinatorial expression patterns of Hoxd genes in single cells of the developing limb, which are associated with the temporal progression of cell differentiation

Parkin Mutations and Glutamatergic Signaling

In their new paper, Clarissa Waites and colleagues find that Parkinson’s disease –associated mutations in the E3 ubiquitin ligase Parkin alter glutamatergic transmission in hippocampal neurons by impeding NMDA and AMPA receptor trafficking

Untangling the Genetics end Ecology of Rice Traits

Quan Xu and colleagues identify QTLs related to 15 agronomic traits such as yield and quality in rice, which are associated with differential responses to environmental conditions

Integration of Environmental Signals via piRNAs

Peter Sarkies and colleagues demonstate that the piRNA pathway integrates inputs from the environment to establish intergenerational responses to environmental conditions with consequences for the fitness of the subsequent generation

Call for Papers – "Engineering Biology" series

We are delighted to invite submission of Research papers to our latest series, under the Guest Editorship of James Collins, Sophien Kamoun, Nicola Patron, James Wells, and Pamela Silver. For more details, please read here!

Call for Papers – Special Issue on Cancer Metabolism

We are now inviting submissions of Research papers for our cross-journal special issue. Guest Editors: Navdeep Chandel, Matthew Vander Heiden, Karen Vousden and Kathryn Wellen; submission deadline - October 31^st 2018. Read more here!

Featured Review

Targeting protein quality control pathways in breast cancer

Sara Sannino and Jeffrey L. Brodsky

Published on: 26 November 2017

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Articles

Content type: Comment
| 24 September 2018

Open questions: CRISPR biology

Authors: Eugene V. Koonin
Content type: Research article
| 20 September 2018

Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance

Authors: Jessica M. Stringer, Samuel C. Forster, Zhipeng Qu, Lexie Prokopuk, Moira K. O’Bryan, David K. Gardner, Stefan J. White, David Adelson and Patrick S. Western
Content type: Research article
| 18 September 2018

The piRNA pathway responds to environmental signals to establish intergenerational adaptation to stress

Authors: Tony Belicard, Pree Jareosettasin and Peter Sarkies
Content type: Research article
| 18 September 2018

Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development

Authors: P. J. Fabre, M. Leleu, B. Mascrez, Q. Lo Giudice, J. Cobb and D. Duboule
Content type: Research article
| 18 September 2018

Genome sequencing of rice subspecies and genetic analysis of recombinant lines reveals regional yield- and quality-associated loci

Authors: Xiukun Li, Lian Wu, Jiahong Wang, Jian Sun, Xiuhong Xia, Xin Geng, Xuhong Wang, Zhengjin Xu and Quan Xu

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Research
Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes
Pauline Salis, Natacha Roux, Olivier Soulat, David Lecchini, Vincent Laudet and Bruno Frédérich
Published on: 05 September 2018

Methodology
Cell fixation and preservation for droplet-based single-cell transcriptomics
Jonathan Alles, Nikos Karaiskos, Samantha D. Praktiknjo, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks and Nikolaus Rajewsky
Published on: 19 May 2017

Research
Clonal raider ant brain transcriptomics identifies candidate molecular mechanisms for reproductive division of labor
Romain Libbrecht, Peter R. Oxley and Daniel J. C. Kronauer
Published on: 13 August 2018

Research
Attention decouples action potentials from the phase of local field potentials in macaque visual cortical area MT
Moein Esghaei, Mohammad Reza Daliri and Stefan Treue
Published on: 06 August 2018

Research
Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication
Amanda L. Pendleton, Feichen Shen, Angela M. Taravella, Sarah Emery, Krishna R. Veeramah, Adam R. Boyko and Jeffrey M. Kidd
Published on: 28 June 2018

Open Questions
Open questions: How many genes do we have?
Steven L. Salzberg
Published on: 20 August 2018

Review
Horizons in the evolution of aging
Thomas Flatt and Linda Partridge
Published on: 20 August 2018

Forum
Non-model model organisms
James J. Russell, Julie A. Theriot, Pranidhi Sood, Wallace F. Marshall, Laura F. Landweber, Lillian Fritz-Laylin, Jessica K. Polka, Snezhana Oliferenko, Therese Gerbich, Amy Gladfelter, James Umen, Magdalena Bezanilla, Madeline A. Lancaster, Shuonan He, Matthew C. Gibson, Bob Goldstein, Elly M. Tanaka, Chi-Kuo Hu and Anne Brunet
Published on: 29 June 2017

Review
Tissue macrophages: heterogeneity and functions
Siamon Gordon and Annette Plüddemann
Published on: 29 June 2017

Q&A
Peto’s Paradox: how has evolution solved the problem of cancer prevention?
Marc Tollis, Amy M. Boddy and Carlo C. Maley
Published on: 13 July 2017

Content type: Research article
| 24 September 2009

scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Authors: Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson and Anthony M Brumby
Content type: Review
| 28 October 2011

Molecular dynamics simulations and drug discovery

Authors: Jacob D Durrant and J Andrew McCammon
Content type: Question and Answer
| 30 September 2011

Q&A: What is the Golgi apparatus, and why are we asking?

Authors: Sean Munro
Content type: Research article
| 23 November 2009

Mapping cortical hubs in tinnitus

Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz
Content type: Forum
| 14 December 2012

What determines cell size?

Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

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Focus: Immunology in Health and Disease

Read the latest Reviews on immunology across BMC flagship journals.

Advances in immunotherapy for melanoma
Jason M. Redman, Geoffrey T. Gibney and Michael B. Atkins
Published in BMC Medicine on: 6 February 2016

Tissue macrophages: heterogeneity and functions
Siamon Gordon and Annette Plüddemann
Published in BMC Biology on: 29 June 2017

Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance
Cornelis J. M. Melief and Jan H. Kessler
Published in Genome Medicine on: 24 May 2017

The MHC locus and genetic susceptibility to autoimmune and infectious diseases
Vasiliki Matzaraki, Vinod Kumar, Cisca Wijmenga and Alexandra Zhernakova
Published in Genome Biology on: 27 April 2017