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Identification of Cell Types in a Mouse Brain

Arnold Kriegstein and Apharna Badhuri show that analysis of 50.000 cells can recapitulate the structure of a 1.3 million cell RNAseq mouse brain atlas, suggesting that profiling more individuals at low cell resolution may be beneficial for atlas-scale studies

Open Questions: What Constitutes an Individual?

Our Editorial Board Member Robin Weiss considers how unique examples from nature such as chimeric animals and transmissible cancer cells inform us on the nature of  individuality in multicellular organisms

Post-Translational Modifications Driving Platelet Formation

Nathalie Morin and colleagues show that polyglutamylation and acetylation of microtubules drive the morphological changes happening during proplatelet maturation, critical for platelet release and function

Call for Papers – Special Issue on Cancer Metabolism

We are now inviting submissions of Research papers for our cross-journal special issue. Guest Editors: Navdeep Chandel, Matthew Vander Heiden, Karen Vousden and Kathryn Wellen; submission deadline - December 1st 2018. Read more here!

Call for Papers: Microbiome Biology

BMC Biology and Genome Biology are inviting submission for their upcoming joint special issue on Microbiome Biology scheduled for publication in Spring 2019

A Mechanism for H3.3 Recognition and Deposition

In their new paper, Guohong Li and colleagues identify the mechanism through which the HIRA complex specifically recognizes and deposits H3.3 at promoters and enhancers of developmental genes, affecting neural differentiation

Featured Commentary

Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse

Thomas M. Coate and Katherine Conant

Published on: 26 September 2018


Loss of males from mixed-sex societies in termites
Toshihisa Yashiro, Nathan Lo, Kazuya Kobayashi, Tomonari Nozaki, Taro Fuchikawa, Nobuaki Mizumoto, Yusuke Namba and Kenji Matsuura
Published on: 25 September 2018

Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes
Pauline Salis, Natacha Roux, Olivier Soulat, David Lecchini, Vincent Laudet and Bruno Frédérich
Published on: 05 September 2018

Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development
P. J. Fabre, M. Leleu, B. Mascrez, Q. Lo Giudice, J. Cobb and D. Duboule
Published on: 18 September 2018

Cell fixation and preservation for droplet-based single-cell transcriptomics
Jonathan Alles, Nikos Karaiskos, Samantha D. Praktiknjo, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks and Nikolaus Rajewsky
Published on: 19 May 2017

Cell type-specific expression profiling unravels the development and evolution of stinging cells in sea anemone​​​​​​​
Kartik Sunagar, Yaara Y Columbus-Shenkar, Arie Fridrich, Nadya Gutkovich, Reuven Aharoni and Yehu Moran
Published on: 27 September 2018

Open Questions
Open questions: How many genes do we have?
Steven L. Salzberg
Published on: 20 August 2018

Open Questions
Open questions: CRISPR biology
Eugene V. Koonin
Published on: 24 September 2018

Horizons in the evolution of aging
Thomas Flatt and Linda Partridge
Published on: 20 August 2018

The disposable male— the ultimate emancipation of females?
Duur K. Aanen
Published on: 25 September 2018

Tissue macrophages: heterogeneity and functions
Siamon Gordon and Annette Plüddemann
Published on: 29 June 2017

  1. Content type: Research article


    Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

  2. Content type: Forum


    Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

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Focus: the Microbiome

Read the latest Reviews on microbiomes across BMC flagship journals.

The gut microbiome in human immunodeficiency virus infection
Gili Zilberman-Schapira, Niv Zmora, Shlomik Itav, Stavros Bashiardes, Hila Elinav and Eran Elinav
Published in BMC Medicine on: 3 June 2016

The human microbiome in evolution
Emily R. Davenport, Jon G. Sanders, Se Jin Song, Katherine R. Amato, Andrew G. Clark and Rob Knight
Published in BMC Biology on: 27 December2017

The healthy human microbiome
Jason Lloyd-Price, Galeb Abu-Ali and Curtis Huttenhower
Published in Genome Medicine on: 27 April 2016

Experimental design and quantitative analysis of microbial community multiomics
Jason Lloyd-Price, Galeb Abu-Ali and Curtis Huttenhower Himel Mallick, Siyuan Ma, Eric A. Franzosa, Tommi Vatanen, Xochitl C. Morgan and Curtis Huttenhower
Published in Genome Biology on: 30 November 2017