BMC Biology

Protein aggregates in natural and synthetic biology

Mo Khalil, Giulio Chiesa and Szilvia Kiriakov discuss protein aggregates in biology, and how self-assembling systems can be harnessed for the purposeful manipulation of biological function.

Mapping the live brain

Ryo Yoshida, Yuichi Iino and colleagues annotated neuronal identities in live C. elegans, creating a dataset of their expression patterns and positions to allow automated identification of neurons during live imaging.

Chromosomal diversity in Aedes aegypti

Seth Redmond and colleagues characterize chromosomal diversity in subspecies of Aedes aegypti, creating a library of genomic rearrangements as an important resource for genetic studies of this mosquito vector.

Introducing our Research Synthesis Series

In their inaugural Editorial, our Guest Editors Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod, and Wolfgang Viechtbauer discuss how meta-analyses and other research synthesis methodologies support research, and the benefits of embracing them across biological disciplines.

Pervasive contamination in bacterial WGS datasets

New research from Galo Goig and colleagues finds that short-read contaminants are pervasive in bacterial whole-genome sequencing datasets, and that they can introduce large biases in variant analyses.

Call for papers: Research Synthesis and Meta-research in Biology

We’re inviting submissions to our new Series guest edited by Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod and Wolfgang Viechtbauer.

Articles

Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction

Authors: Elena Clementi, Larissa Inglin, Erin Beebe, Corina Gsell, Zuzana Garajova and Enni Markkanen

Content type: Research article

30 March 2020
Protein assembly systems in natural and synthetic biology

Authors: Giulio Chiesa, Szilvia Kiriakov and Ahmad S. Khalil

Content type: Review

26 March 2020
TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles

Authors: Nina Strah, Giulia Romano, Clelia Introna, Raffaella Klima, Marta Marzullo, Laura Ciapponi, Aram Megighian, Monica Nizzardo and Fabian Feiguin

Content type: Research article

26 March 2020
Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1

Authors: Chunming Gu, Zhao Yin, Hong Nie, Yanjun Liu, Juhua Yang, Guiping Huang, Jianping Shen, Liguo Chen and Jia Fei

Content type: Research article

25 March 2020
DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy

Authors: Szymon J. Szymura, Giovanna M. Bernal, Longtao Wu, Zhongqin Zhang, Clayton D. Crawley, David J. Voce, Paige-Ashley Campbell, Diana E. Ranoa, Ralph R. Weichselbaum and Bakhtiar Yamini

Content type: Research article

24 March 2020

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Research
Evolutionary superscaffolding and chromosome anchoring to improve Anopheles genome assemblies
Robert M. Waterhouse et al.
Published on: 02 January 2020

Research
Charting the diversity of uncultured viruses of Archaea and Bacteria
F. H. Coutinho et al.
Published on: 29 December 2019

Research
Long live the king: chromosome-level assembly of the lion (Panthera leo) using linked-read, Hi-C, and long-read data
Ellie E. Armstrong et al.
Published on: 08 January 2020

Research
The X chromosome of the German cockroach, Blattella germanica, is homologous to a fly X chromosome despite 400 million years divergence
Richard P. Meisel et al.
Published on: 05 December 2019

Methodology
Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation
Elin Lundin et al.
Published on: 14 January 2020

Review
Unlocking the origins and biology of domestic animals using ancient DNA and paleogenomics
Gillian P. McHugo et al.
Published 02 December 2019

Review
Are we there yet? The long walk towards the development of efficient symbiotic associations between nitrogen-fixing bacteria and non-leguminous crops
Vânia C. S. Pankievicz et al.
Published 03 December 2019

Review
The microbiome of the upper respiratory tract in health and disease
Christina Kumpitsch, Kaisa Koskinen, Veronika Schöpf & Christine Moissl-Eichinger
Published: 07 November 2019

Review
The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health
Jillian L. Waters & Ruth E. Ley
Published: 28 October 2019

Review
Studying the gut virome in the metagenomic era: challenges and perspectives
Sanzhima Garmaeva, Trishla Sinha, Alexander Kurilshikov, Jingyuan Fu, Cisca Wijmenga & Alexandra Zhernakova
Published: 28 October 2019

scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Authors: Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson and Anthony M Brumby

Content type: Research article

24 September 2009
Molecular dynamics simulations and drug discovery

Authors: Jacob D Durrant and J Andrew McCammon

Content type: Review

28 October 2011
Q&A: What is the Golgi apparatus, and why are we asking?

Authors: Sean Munro

Content type: Question and Answer

30 September 2011
Mapping cortical hubs in tinnitus

Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

Content type: Research article

23 November 2009
Reagent and laboratory contamination can critically impact sequence-based microbiome analyses

Authors: Susannah J Salter, Michael J Cox, Elena M Turek, Szymon T Calus, William O Cookson, Miriam F Moffatt, Paul Turner, Julian Parkhill, Nicholas J Loman and Alan W Walker

Content type: Research article

12 November 2014