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Protein aggregates in natural and synthetic biology

Mo Khalil, Giulio Chiesa and Szilvia Kiriakov discuss protein aggregates in biology, and how self-assembling systems can be harnessed for the purposeful manipulation of biological function.

Mapping the live brain

Ryo Yoshida, Yuichi Iino and colleagues annotated neuronal identities in live C. elegans, creating a dataset of their expression patterns and positions to allow automated identification of neurons during live imaging.

Chromosomal diversity in Aedes aegypti

Seth Redmond and colleagues characterize chromosomal diversity in subspecies of Aedes aegypti, creating a library of genomic rearrangements as an important resource for genetic studies of this mosquito vector.

Introducing our Research Synthesis Series

In their inaugural Editorial, our Guest Editors Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod, and Wolfgang Viechtbauer discuss how meta-analyses and other research synthesis methodologies support research, and the benefits of embracing them across biological disciplines.

Pervasive contamination in bacterial WGS datasets

New research from Galo Goig and colleagues finds that short-read contaminants are pervasive in bacterial whole-genome sequencing datasets, and that they can introduce large biases in variant analyses.

Call for papers: Research Synthesis and Meta-research in Biology

We’re inviting submissions to our new Series guest edited by Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod and Wolfgang Viechtbauer.

Featured Editorial

Introducing our series: research synthesis and meta-research in biology

Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod & Wolfgang Viechtbauer

Published 05 March 2020


Unlocking the origins and biology of domestic animals using ancient DNA and paleogenomics
Gillian P. McHugo et al.
Published 02 December 2019

Are we there yet? The long walk towards the development of efficient symbiotic associations between nitrogen-fixing bacteria and non-leguminous crops
Vânia C. S. Pankievicz et al.
Published 03 December 2019

The microbiome of the upper respiratory tract in health and disease
Christina Kumpitsch, Kaisa Koskinen, Veronika Schöpf & Christine Moissl-Eichinger
Published: 07 November 2019

The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health
Jillian L. Waters & Ruth E. Ley
Published: 28 October 2019

Studying the gut virome in the metagenomic era: challenges and perspectives
Sanzhima Garmaeva, Trishla Sinha, Alexander Kurilshikov, Jingyuan Fu, Cisca Wijmenga & Alexandra Zhernakova
Published: 28 October 2019

  1. Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

    Content type: Research article

Focus: Cancer

Read the latest papers on Cancer across BMC flagship journals.

Development and validation of a prognostic model to predict the prognosis of patients who underwent chemotherapy and resection of pancreatic adenocarcinoma: a large international population-based cohort study
Lei Huang et al.

Published in BMC Medicine 25 March 2019

An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration​​​​​​​
Virginia Tajadura-Ortega et al.

Published in BMC Biology 06 March 2018

Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis​​​​​​​
Markus Mayrhofer et al.

Published in Genome Medicine 21 November 2018

Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma​​​​​​​
Domenico Alessandro Silvestris et al.

Published in Genome Biology 13 February 2019

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Announcement: COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.