The replication machinery of LUCA: common origin of DNA replication and transcription
Eugene V. Koonin, Mart Krupovic, Sonoko Ishino and Yoshizumi Ishino.
Published 09 June 2020
How Gardenias became chemists
The genome sequence of Gardenia jasminoides yields insights into the ways gene duplications drove the divergent evolution of the crocin and caffeine biosynthetic pathways.
Dissecting the functions of acetyl-CoA in Toxoplasma Gondii
Using multi-omics approaches, Dominique Soldati-Favre and colleagues examine the role of distinct acetyl-CoA subcellular pools in the pathogen Toxoplasma gondii, identifying their distinct roles in the synthesis of parasite-specific fatty acids, and impact on metabolic processes.
The rise of metabolic diversity across the Candidate Phyla Radiation
Mapping bacterial genomes and metabolic capacities allowed the identification of the evolutionary processes driving metabolic diversity in the Candidate Phyla Radiation lineages.
The merger that made us
Buzz Baum and David Baum comment on the evolution of eukaryotic cells, and how discoveries of new microbes chart the path to eukaryogenesis.
Targeted approaches for epigenetic age predictions
DNA methylation analysis based on pyrosequencing, ddPCR, and BBA-seq approaches enables high-precision epigenetic age-predictions and demonstrated that the stochastic evolution of age-associated methylation patterns enables epigenetic clocks for individual DNA strands.
Call for papers: Research Synthesis and Meta-research in Biology
We’re inviting submissions to our new Series guest edited by Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod and Wolfgang Viechtbauer.
Featured Opinion
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TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity
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AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions
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Epigenomics and genotype-phenotype association analyses reveal conserved genetic architecture of complex traits in cattle and human
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Relationship between oxygen consumption and neuronal activity in a defined neural circuit
Research
Evolutionary superscaffolding and chromosome anchoring to improve Anopheles genome assemblies
Robert M. Waterhouse et al.
Published on: 02 January 2020
Research
Charting the diversity of uncultured viruses of Archaea and Bacteria
F. H. Coutinho et al.
Published on: 29 December 2019
Research
Long live the king: chromosome-level assembly of the lion (Panthera leo) using linked-read, Hi-C, and long-read data
Ellie E. Armstrong et al.
Published on: 08 January 2020
Research
The X chromosome of the German cockroach, Blattella germanica, is homologous to a fly X chromosome despite 400 million years divergence
Richard P. Meisel et al.
Published on: 05 December 2019
Methodology
Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation
Elin Lundin et al.
Published on: 14 January 2020
Review
Unlocking the origins and biology of domestic animals using ancient DNA and paleogenomics
Gillian P. McHugo et al.
Published 02 December 2019
Review
Are we there yet? The long walk towards the development of efficient symbiotic associations between nitrogen-fixing bacteria and non-leguminous crops
Vânia C. S. Pankievicz et al.
Published 03 December 2019
Review
The microbiome of the upper respiratory tract in health and disease
Christina Kumpitsch, Kaisa Koskinen, Veronika Schöpf & Christine Moissl-Eichinger
Published: 07 November 2019
Review
The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health
Jillian L. Waters & Ruth E. Ley
Published: 28 October 2019
Review
Studying the gut virome in the metagenomic era: challenges and perspectives
Sanzhima Garmaeva, Trishla Sinha, Alexander Kurilshikov, Jingyuan Fu, Cisca Wijmenga & Alexandra Zhernakova
Published: 28 October 2019
Focus: Cancer
Read the latest papers on cancer across BMC flagship journals.
Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
Heinz Freisling et al.
Published in BMC Medicine 10 January 2020
Joint learning improves protein abundance prediction in cancers
Hongyang Li et al.
Published in BMC Biology 23 December 2019
Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines
Hang Ruan et al.
Published in Genome Medicine 26 August 2019
Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures
Oguzhan Begik et al.
Published in Genome Biology 07 May 2020
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