BMC Biology

Epigenome editing via exogenous DNA

Jay Shendure and colleagues demonstrate functional silencing of a gene through CRISPR/Cas9 mediated insertion of exogenously methylated DNA sequence.

A common X for cockroaches and flies

Richard Meisel and colleagues find that the X chromosome of the German cockroach and Drosophila are homologous, suggesting the existence of a common X chromosome in an ancestor, or its convergent evolution in the two species.

Going viral in the gut

Zhernakova and colleagues discuss the viral component of the gut ecosystem, the challenges of studying the bacteriophages that shape our gut microbiomes, and what we know so far of their role in health and disease.

A beneficial family of bacteria

Jillian Waters and Ruth Ley review what we have learned about the Christensenellaceae, a recently-discovered family of gut bacteria that is widespread, heritable, and significantly associated with human health.

The developmental cell lineage of the annelid brain

Spiral cleavage patterns produce radially arranged blastomeres, but spiralian larvae later metamorphose into fully bilateral juveniles. The cell lineage of the Platynereis larval episphere may help reveal how bilateral symmetry of the head emerges.

The Evolution of Regeneration

Ramon-Mateu and colleagues use the comb jelly as a model to show that cell proliferation is required for regeneration in ctenophores, but is separable from wound healing; and might shed light on regenerative diversity among metazoans.

Articles

SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation

Authors: Yan Zhang, Liwei Zheng, Michael Le, Yukiko Nakano, Barry Chan, Yulei Huang, Parisa Moravedje Torbaty, Yoshinori Kohwi, Ralph Marcucio, Stefan Habelitz, Pamela K. Den Besten and Terumi Kohwi-Shigematsu

Content type: Research article

13 December 2019
Extracting physiological information in experimental biology via Eulerian video magnification

Authors: Henrik Lauridsen, Selina Gonzales, Daniela Hedwig, Kathryn L. Perrin, Catherine J. A. Williams, Peter H. Wrege, Mads F. Bertelsen, Michael Pedersen and Jonathan T. Butcher

Content type: Methodology article

12 December 2019
Transcriptome resilience predicts thermotolerance in Caenorhabditis elegans

Authors: Katharina Jovic, Jacopo Grilli, Mark G. Sterken, Basten L. Snoek, Joost A. G. Riksen, Stefano Allesina and Jan E. Kammenga

Content type: Research article

10 December 2019
Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae

Authors: Shardul D. Kulkarni, Fujun Zhou, Neelam Dabas Sen, Hongen Zhang, Alan G. Hinnebusch and Jon R. Lorsch

Content type: Research article

6 December 2019
The X chromosome of the German cockroach, Blattella germanica, is homologous to a fly X chromosome despite 400 million years divergence

Authors: Richard P. Meisel, Pablo J. Delclos and Judith R. Wexler

Content type: Research Article

5 December 2019

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Research
Genomic adaptations to chemosymbiosis in the deep-sea seep-dwelling tubeworm Lamellibrachia luymesi
Yuanning Li, Michael G. Tassia, Damien S. Waits, Viktoria E. Bogantes, Kyle T. David & Kenneth M. Halanych
Published on: 18 November 2019

Research
Single-cell reconstruction of differentiation trajectory reveals a critical role of ETS1 in human cardiac lineage commitment
Hang Ruan, Yingnan Liao, Zongna Ren, Lin Mao, Fang Yao, Peng Yu, Youqiong Ye, Zhao Zhang, Shengli Li, Hanshi Xu, Jiewei Liu, Lixia Diao, Bingying Zhou, Leng Han & Li Wang
Published on: 13 November 2019

Research
GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse
Avinash S. Gaikwad, Amanda L. Anderson, D. Jo Merriner, Anne E. O’Connor, Brendan J. Houston, R. John Aitken, Moira K. O’Bryan & Brett Nixon
Published on: 31 October 2019

Research
Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study
Matthias Willmann, Maria J. G. T. Vehreschild, Lena M. Biehl, Wichard Vogel, Daniela Dörfel, Axel Hamprecht, Harald Seifert, Ingo B. Autenrieth & Silke Peter
Published on: 18 September 2019

Methodology
A systematic sequencing-based approach for microbial contaminant detection and functional inference
Sung-Joon Park, Satoru Onizuka, Masahide Seki, Yutaka Suzuki, Takanori Iwata & Kenta Nakai
Published on: 13 September 2019

Review
The microbiome of the upper respiratory tract in health and disease
Christina Kumpitsch, Kaisa Koskinen, Veronika Schöpf & Christine Moissl-Eichinger
Published: 07 November 2019

Review
The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health
Jillian L. Waters & Ruth E. Ley
Published: 28 October 2019

Review
Studying the gut virome in the metagenomic era: challenges and perspectives
Sanzhima Garmaeva, Trishla Sinha, Alexander Kurilshikov, Jingyuan Fu, Cisca Wijmenga & Alexandra Zhernakova
Published: 28 October 2019

Review
Viral hijacking of cellular metabolism
Shivani K. Thaker, James Ch’ng & Heather R. Christofk
Published: 18 July 2019

Comment
Multiple levels of the unknown in microbiome research
Andrew Maltez Thomas & Nicola Segata
Published: 12 June 2019

scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Authors: Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson and Anthony M Brumby

Content type: Research article

24 September 2009
Molecular dynamics simulations and drug discovery

Authors: Jacob D Durrant and J Andrew McCammon

Content type: Review

28 October 2011
Q&A: What is the Golgi apparatus, and why are we asking?

Authors: Sean Munro

Content type: Question and Answer

30 September 2011
Mapping cortical hubs in tinnitus

Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

Content type: Research article

23 November 2009
Reagent and laboratory contamination can critically impact sequence-based microbiome analyses

Authors: Susannah J Salter, Michael J Cox, Elena M Turek, Szymon T Calus, William O Cookson, Miriam F Moffatt, Paul Turner, Julian Parkhill, Nicholas J Loman and Alan W Walker

Content type: Research article

12 November 2014