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Epigenome editing via exogenous DNA

Jay Shendure and colleagues demonstrate functional silencing of a gene through CRISPR/Cas9 mediated insertion of exogenously methylated DNA sequence.

A common X for cockroaches and flies

Richard Meisel and colleagues find that the X chromosome of the German cockroach and Drosophila are homologous, suggesting the existence of a common X chromosome in an ancestor, or its convergent evolution in the two species.

Going viral in the gut

Zhernakova and colleagues discuss the viral component of the gut ecosystem, the challenges of studying the bacteriophages that shape our gut microbiomes, and what we know so far of their role in health and disease.

A beneficial family of bacteria

Jillian Waters and Ruth Ley review what we have learned about the Christensenellaceae, a recently-discovered family of gut bacteria that is widespread, heritable, and significantly associated with human health.

The developmental cell lineage of the annelid brain

Spiral cleavage patterns produce radially arranged blastomeres, but spiralian larvae later metamorphose into fully bilateral juveniles. The cell lineage of the Platynereis larval episphere may help reveal how bilateral symmetry of the head emerges.

The Evolution of Regeneration

Ramon-Mateu and colleagues use the comb jelly as a model to show that cell proliferation is required for regeneration in ctenophores, but is separable from wound healing; and might shed light on regenerative diversity among metazoans.

Featured Review

Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches

Shoval Lagziel, Won Dong Lee & Tomer Shlomi

Published on: 04 July 2019

Articles

Research
Genomic adaptations to chemosymbiosis in the deep-sea seep-dwelling tubeworm Lamellibrachia luymesi
Yuanning Li, Michael G. Tassia, Damien S. Waits, Viktoria E. Bogantes, Kyle T. David & Kenneth M. Halanych
Published on: 18 November 2019

Research
Single-cell reconstruction of differentiation trajectory reveals a critical role of ETS1 in human cardiac lineage commitment
Hang Ruan, Yingnan Liao, Zongna Ren, Lin Mao, Fang Yao, Peng Yu, Youqiong Ye, Zhao Zhang, Shengli Li, Hanshi Xu, Jiewei Liu, Lixia Diao, Bingying Zhou, Leng Han & Li Wang
Published on: 13 November 2019

Research
GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse
Avinash S. Gaikwad, Amanda L. Anderson, D. Jo Merriner, Anne E. O’Connor, Brendan J. Houston, R. John Aitken, Moira K. O’Bryan & Brett Nixon
Published on: 31 October 2019

Research
Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study
Matthias Willmann, Maria J. G. T. Vehreschild, Lena M. Biehl, Wichard Vogel, Daniela Dörfel, Axel Hamprecht, Harald Seifert, Ingo B. Autenrieth & Silke Peter
Published on: 18 September 2019

Methodology
A systematic sequencing-based approach for microbial contaminant detection and functional inference
Sung-Joon Park, Satoru Onizuka, Masahide Seki, Yutaka Suzuki, Takanori Iwata & Kenta Nakai
Published on: 13 September 2019

Review
The microbiome of the upper respiratory tract in health and disease
Christina Kumpitsch, Kaisa Koskinen, Veronika Schöpf & Christine Moissl-Eichinger
Published: 07 November 2019

Review
The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health
Jillian L. Waters & Ruth E. Ley
Published: 28 October 2019

Review
Studying the gut virome in the metagenomic era: challenges and perspectives
Sanzhima Garmaeva, Trishla Sinha, Alexander Kurilshikov, Jingyuan Fu, Cisca Wijmenga & Alexandra Zhernakova
Published: 28 October 2019

Review
Viral hijacking of cellular metabolism
Shivani K. Thaker, James Ch’ng & Heather R. Christofk
Published: 18 July 2019

Comment
Multiple levels of the unknown in microbiome research
Andrew Maltez Thomas & Nicola Segata
Published: 12 June 2019

  1. Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

    Content type: Research article

Focus: Breast Cancer

Read the latest papers on Breast Cancer across BMC flagship journals.

Safety, activity, and molecular heterogeneity following neoadjuvant non-pegylated liposomal doxorubicin, paclitaxel, trastuzumab, and pertuzumab in HER2-positive breast cancer (Opti-HER HEART): an open-label, single-group, multicenter, phase 2 trial
Joaquin Gavila et al.

Published in BMC Medicine 09 January 2019

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
Florian Bonin et al.

Published in BMC Biology 02 October 2018

Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations
Elen Kristine Hoglander et al.

Published in Genome Medicine 29 November 2018

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer​​​​​​​
Andrew N. Holding et al.

Published in Genome Biology 13 May 2019

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