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Inactivation of CRISPR-Cas systems by anti-CRISPR proteins

In their review, Yuwei Zhu and colleagues provide an overview of anti-CRISPR protein diversity, focusing on their structure and topology, and the insights this provides into their mechanisms of inhibition

Reviews in BMC Biology

Stay up to date with our authoritative Reviews from leaders in the field, on topics including the microbiome, cancer, evolution, neurobiology, cell biology and genetics

Chimeric genes at the origin of eukaryotes

In new research from our “In the Light of Evolution” series, Méheust et al explore how fusion of prokaryotic gene fragments might contribute to novel chimeric genes and cellular complexity during eukaryogenesis

Evolving dopamine transporters

Harel Weinstein and colleagues examine how functional properties of human neurotransmitter transporters emerge from bacterial homologues through evolutionary adaptation

Collections’ Highlights

From our “Protein Quality Control at Membrane” series, Elizabeth Craig reviews how Hsp70s function at the membrane to drive protein translocation

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Research from Max Telford and colleagues– A software tool ‘CroCo’ detects pervasive cross-species contamination in next generation sequencing data

Featured Review

How driving endonuclease genes can be used to combat pests and disease vectors

H. Charles J. Godfray, Ace North and Austin Burt

Published on: 11 September 2017




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A software tool ‘CroCo’ detects pervasive cross-species contamination in next generation sequencing data​​​​​​​
Paul Simion, Khalid Belkhir, Clémentine François, Julien Veyssier, Jochen C. Rink, Michaël Manuel, Hervé Philippe and Maximilian J. Telford
Published on: 5 March 2018

A sophisticated, differentiated Golgi in the ancestor of eukaryotes
Lael D. Barlow, Eva Nývltová, Maria Aguilar, Jan Tachezy and Joel B. Dacks
Published on: 7 March 2018

Formation of chimeric genes with essential functions at the origin of eukaryotes
Raphaël Méheust, Debashish Bhattacharya, Jananan S. Pathmanathan, James O. McInerney, Philippe Lopez and Eric Bapteste
Published on: 13 March 2018

Cell fixation and preservation for droplet-based single-cell transcriptomics
Jonathan Alles, Nikos Karaiskos, Samantha D. Praktiknjo, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks and Nikolaus Rajewsky
Published on: 19 May 2017

An adaptable chromosome preparation methodology for use in invertebrate research organisms
Longhua Guo, Alice Accorsi, Shuonan He, Carlos Guerrero-Hernández, Shamilene Sivagnanam, Sean McKinney, Matthew Gibson and Alejandro Sánchez Alvarado
Published on: 26 February 2018

Nothing in cancer makes sense except…
Mel Greaves
Published on: 21 February 2018

Targeting protein quality control pathways in breast cancer
Sara Sannino and Jeffrey L. Brodsky
Published on: 16 November 2017

Measuring behavior across scales
Gordon J. Berman
Published on: 23 February 2018

The human microbiome in evolution
Emily R. Davenport, Jon G. Sanders, Se Jin Song, Katherine R. Amato, Andrew G. Clark and Rob Knight
Published on: 27 December 2017

Tissue macrophages: heterogeneity and functions
Siamon Gordon and Annette Plüddemann
Published on: 29 June 2017

  1. Content type: Research article


    Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

  2. Content type: Forum


    Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

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BMC Biology is a broad scope journal covering all areas of biology. Our content includes research articles, new methods and tools. BMC Biology also publishes reviews, Q&A, and commentaries.