Featured Review
Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches
Shoval Lagziel, Won Dong Lee & Tomer Shlomi
Published on: 04 July 2019
The Roots of Strigolactone Signaling
Tom Bennett and colleagues examine the evolution of the plant signaling molecules strigolactones, determining that their synthesis is more ancient than their canonical signaling, suggesting that they evolved as rhizosphere signals and recruited much later as hormonal signals.
Genetic Voltage Indicators
Rafael Yuste and colleagues review advances in the design and use of genetic voltage indicators, and how their applications in imaging membrane potential can bring about unprecedented understanding of synaptic activity in neuronal populations.
Finding Microbial Contamination in NGS Data
A computational method for profiling microbial contamination in NGS data by Kenta Nakai and colleagues, suggests that microbial contamination of laboratory reagents and environment leads to changes in gene expression and phenotypes of cell lines.
New Players in Chromosome Alignment
Jianguo Chen and Junlin Teng characterize two previously uncharacterized coiled-coil domain proteins that localize to spindles and are important K-fiber crosslinkers, demonstrating that they are required for bipolar spindle formation and chromosome alignment.
Omics of White Adipose Tissue
Lipidomic and transcriptome profiles of browning WAT presented by Tizhong Shan and colleagues demonstrates the dynamic alterations in WAT upon exposure to cold, and represent a resource for examining the process of browning in health and disease.
Cancer Metabolism Series
Our Series on Cancer Metabolism highlights advances in our understanding of cancer metabolism through commissioned Reviews and Q&As from leaders in the field.
Articles
Methodology
A systematic sequencing-based approach for microbial contaminant detection and functional inference
Sung-Joon Park, Satoru Onizuka, Masahide Seki, Yutaka Suzuki, Takanori Iwata & Kenta Nakai
Published on: 13 September 2019
Research
Functional annotation of the cattle genome through systematic discovery and characterization of chromatin states and butyrate-induced variations
Lingzhao Fang, Shuli Liu, Mei Liu, Xiaolong Kang, Shudai Lin, Bingjie Li, Erin E. Connor, Ransom L. Baldwin VI, Albert Tenesa, Li Ma, George E. Liu & Cong-jun Li
Published on: 16 August 2019
Research
Metagenomes and metatranscriptomes shed new light on the microbial-mediated sulfur cycle in a Siberian soda lake
Charlotte D. Vavourakis, Maliheh Mehrshad, Cherel Balkema, Rutger van Hall, Adrian-Ştefan Andrei, Rohit Ghai, Dimitry Y. Sorokin & Gerard Muyzer
Published on: 22 August 2019
Research
Strigolactone synthesis is ancestral in land plants, but canonical strigolactone signalling is a flowering plant innovation
Catriona H. Walker, Karen Siu-Ting, Alysha Taylor, Mary J. O’Connell & Tom Bennett
Published on: 05 September 2019
Research
Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study
Matthias Willmann, Maria J. G. T. Vehreschild, Lena M. Biehl, Wichard Vogel, Daniela Dörfel, Axel Hamprecht, Harald Seifert, Ingo B. Autenrieth & Silke Peter
Published on: 18 September 2019
Review
Synthetic Biology Goes Cell-Free
Aidan Tinafar, Katariina Jaenes & Keith Pardee
Pubished on: 8 August 2019
Review
Viral hijacking of cellular metabolism
Shivani K. Thaker, James Ch’ng & Heather R. Christofk
Published on: 18 July 2019
Comment
Multiple levels of the unknown in microbiome research
Andrew Maltez Thomas & Nicola Segata
Published on: 12 June 2019
Review
Mitochondrial DNA: the overlooked oncogenome?
Payam A. Gammage & Christian Frezza
Published on: 08 July 2019
Review
Genetic voltage indicators
Yuki Bando, Christiane Grimm, Victor H Cornejo & Rafael Yuste
Published on: 12 September 2019
Focus: Neurology in Health and Disease
Read the latest papers on Neurology across BMC flagship journals.
Clinical and cost-effectiveness of contingency management for cannabis use in early psychosis: the CIRCLE randomised clinical trial
Luke Sheridan Rains, Louise Marston, Mark Hinton, Steven Marwaha, Thomas Craig, David Fowler, Michael King, Rumana Z. Omar, Paul McCrone, Jonathan Spencer, Joanne Taylor, Sophie Colman, Catherine Harder, Eleanor Gilbert, Amie Randhawa, Kirsty Labuschagne, Charlotte Jones, Theodora Stefanidou, Marina Christoforou, Meghan Craig, John Strang, Tim Weaver & Sonia Johnson
Published in BMC Medicine 15 August 2019
Parkinson’s disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons
Mei Zhu, Giuseppe P. Cortese & Clarissa L. Waites
Published in BMC Biology 10 September 2018
Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer’s disease
Laura M. Winchester, John Powell, Simon Lovestone & Alejo J. Nevado-Holgado
Published in Genome Medicine 28 June 2018
Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex
Zelin Liu, Yuan Ran, Changyu Tao, Sichen Li, Jian Chen & Ence Yang
Published in Genome Biology 20 May 2019
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