Introducing our series: research synthesis and meta-research in biology
Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod & Wolfgang Viechtbauer
Published 05 March 2020
Protein aggregates in natural and synthetic biology
Mo Khalil, Giulio Chiesa and Szilvia Kiriakov discuss protein aggregates in biology, and how self-assembling systems can be harnessed for the purposeful manipulation of biological function.
Mapping the live brain
Ryo Yoshida, Yuichi Iino and colleagues annotated neuronal identities in live C. elegans, creating a dataset of their expression patterns and positions to allow automated identification of neurons during live imaging.
Chromosomal diversity in Aedes aegypti
Seth Redmond and colleagues characterize chromosomal diversity in subspecies of Aedes aegypti, creating a library of genomic rearrangements as an important resource for genetic studies of this mosquito vector.
Introducing our Research Synthesis Series
In their inaugural Editorial, our Guest Editors Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod, and Wolfgang Viechtbauer discuss how meta-analyses and other research synthesis methodologies support research, and the benefits of embracing them across biological disciplines.
Pervasive contamination in bacterial WGS datasets
New research from Galo Goig and colleagues finds that short-read contaminants are pervasive in bacterial whole-genome sequencing datasets, and that they can introduce large biases in variant analyses.
Call for papers: Research Synthesis and Meta-research in Biology
We’re inviting submissions to our new Series guest edited by Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod and Wolfgang Viechtbauer.
Featured Editorial
Articles
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Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction
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Protein assembly systems in natural and synthetic biology
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TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles
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Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1
Research
Evolutionary superscaffolding and chromosome anchoring to improve Anopheles genome assemblies
Robert M. Waterhouse et al.
Published on: 02 January 2020
Research
Charting the diversity of uncultured viruses of Archaea and Bacteria
F. H. Coutinho et al.
Published on: 29 December 2019
Research
Long live the king: chromosome-level assembly of the lion (Panthera leo) using linked-read, Hi-C, and long-read data
Ellie E. Armstrong et al.
Published on: 08 January 2020
Research
The X chromosome of the German cockroach, Blattella germanica, is homologous to a fly X chromosome despite 400 million years divergence
Richard P. Meisel et al.
Published on: 05 December 2019
Methodology
Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation
Elin Lundin et al.
Published on: 14 January 2020
Review
Unlocking the origins and biology of domestic animals using ancient DNA and paleogenomics
Gillian P. McHugo et al.
Published 02 December 2019
Review
Are we there yet? The long walk towards the development of efficient symbiotic associations between nitrogen-fixing bacteria and non-leguminous crops
Vânia C. S. Pankievicz et al.
Published 03 December 2019
Review
The microbiome of the upper respiratory tract in health and disease
Christina Kumpitsch, Kaisa Koskinen, Veronika Schöpf & Christine Moissl-Eichinger
Published: 07 November 2019
Review
The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health
Jillian L. Waters & Ruth E. Ley
Published: 28 October 2019
Review
Studying the gut virome in the metagenomic era: challenges and perspectives
Sanzhima Garmaeva, Trishla Sinha, Alexander Kurilshikov, Jingyuan Fu, Cisca Wijmenga & Alexandra Zhernakova
Published: 28 October 2019
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scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs
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Molecular dynamics simulations and drug discovery
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Q&A: What is the Golgi apparatus, and why are we asking?
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Mapping cortical hubs in tinnitus
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Reagent and laboratory contamination can critically impact sequence-based microbiome analyses
Focus: Pathogens
Read the latest papers on pathogenic organisms and disease across BMC flagship journals.
Population-level mathematical modeling of antimicrobial resistance: a systematic review
Anna Maria Niewiadomska et al.
Published in BMC Medicine 24 April 2019
A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk
Elvire Berthenet et al.
Published in BMC Biology 02 August 2018
INSaFLU: an automated open web-based bioinformatics suite “from-reads” for influenza whole-genome-sequencing-based surveillance
Vítor Borges et al.
Published in Genome Medicine 29 June 2018
HOPS: automated detection and authentication of pathogen DNA in archaeological remains
Ron Hübler et al.
Published in Genome Biology 16 December 2019
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