BMC Biology

Deep learning about neurodegeneration

Adriana San Miguel and colleagues develop a deep learning algorithm to examine complex neurodegenerative patterns in C. elegans, showing distinct morphologies associated with aging or environmental insults.

Brain-wide sensory responses in a fragile X model

Gilles Vanwalleghem, Ethan Scott and colleagues recorded brain-wide neuronal responses at a cellular resolution to visual and auditory stimuli in a zebrafish model of the fragile X syndrome, modelling alterations of sensory networks that underlie the sensory aspects of fragile X syndrome and autism.

Uncoupling of mutations and malignant transformation in CRC

Soulafa Mamlouk, Hendrik Bläker and colleagues analyzed the genetic profiles of colorectal cancer carcinomas and their precursors to assess the timing and heterogeneity of driver mutations, showing that malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression.

How glia regulate lifespan

Linda Partridge and colleagues determine the contributions of distinct glial subpopulations to insulin-like signaling, and their role in the organism-wide modulation of development and lifespan in Drosophila.

Crowdsourcing for new antibiotics

Marek Mutwil and colleagues used crowdsourcing to identify novel components of protein synthesis in bacteria, with 285 undergraduate students processing 26.38 terabytes of RNA-seq data, and predicting more than 100 putative regulators of protein synthesis in 17 bacterial pathogens.

Call for papers: Research Synthesis and Meta-research in Biology

We’re inviting submissions to our new Series guest edited by Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod and Wolfgang Viechtbauer.

Articles

Genomic evidence for recurrent genetic admixture during the domestication of Mediterranean olive trees (Olea europaea L.)

Authors: Irene Julca, Marina Marcet-Houben, Fernando Cruz, Jèssica Gómez-Garrido, Brandon S. Gaut, Concepción M. Díez, Ivo G. Gut, Tyler S. Alioto, Pablo Vargas and Toni Gabaldón

Content type: Research article

26 October 2020
Unbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability

Authors: Emilie Kristine Bagge, Noriko Fujimori-Tonou, Mie Kubota-Sakashita, Takaoki Kasahara and Tadafumi Kato

Content type: Research article

23 October 2020
PHOSPHO1 is a skeletal regulator of insulin resistance and obesity

Authors: Karla J. Suchacki, Nicholas M. Morton, Calvin Vary, Carmen Huesa, Manisha C. Yadav, Benjamin J. Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E. Barrios-Llerena, Anyonya R. Guntur, Zohreh Khavandgar, William P. Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed…

Content type: Research article

22 October 2020
Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness

Authors: Martin Schwersensky, Marianne Rooman and Fabrizio Pucci

Content type: Research article

20 October 2020
Bioengineered human skeletal muscle capable of functional regeneration

Authors: J. W. Fleming, A. J. Capel, R. P. Rimington, P. Wheeler, A. N. Leonard, N. C. Bishop, O. G. Davies and M. P. Lewis

Content type: Research article

20 October 2020

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Research
Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans
Marco Sazzini et al.
Published on: 22 May 2020

Research
Wonky whales: the evolution of cranial asymmetry in cetaceans
Ellen Coombs et al.
Published on: 10 July 2020

Research
Tandem gene duplications drive divergent evolution of caffeine and crocin biosynthetic pathways in plants
Zhichao Xu et al.
Published on: 18 June 2020

Research
Relationship between oxygen consumption and neuronal activity in a defined neural circuit
Suzan Özugur et al.
Published on: 03 July 2020

Review
X-ray computed tomography in life sciences
Shelley D. Rawson et al.
Published 27 February 2020

Comment
The merger that made us
Buzz Baum and David Baum
Published 24 June 2020

Review
Protein assembly systems in natural and synthetic biology
Giulio Chiesa et al.
Published: 26 March 2020

Comment
Improving the usability and comprehensiveness of microbial databases
Caitlin Loeffler et al.
Published: 07 April 2020

scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Authors: Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson and Anthony M Brumby

Content type: Research article

24 September 2009
Molecular dynamics simulations and drug discovery

Authors: Jacob D Durrant and J Andrew McCammon

Content type: Review

28 October 2011
Q&A: What is the Golgi apparatus, and why are we asking?

Authors: Sean Munro

Content type: Question and Answer

30 September 2011
Mapping cortical hubs in tinnitus

Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

Content type: Research article

23 November 2009
What determines cell size?

Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

Content type: Forum

14 December 2012