BMC Biology

A Roundabout Way to Folate Supplementation

David Weinkove and colleagues show that the effectiveness of folic acid supplementation in C. elegans depends on gut microbes which use folate breakdown products to increase their own folate synthesis, impacting C. elegans development and longevity

How Muscle Metabolism Copes with Energetic Challenges

Francois Favier and colleagues show that REDD1 reduces O2 and ATP consumption in muscles by acting on mitochondrial-associated endoplasmic reticulum membranes and the signaling pathways they support

Membrane Dynamics Get Peculiar

A comprehensive ultrastructural analysis of mitotic Drosophila S2 cells by Maurizio Gatti, Anton Strunov and colleagues identifies their unique features, including novel intracellular membranes’ structures and spindle organization

Rapid High-resolution Imaging of Large Biological Samples

Light Sheet Theta Microscopy, developed by Raju Tomer and colleagues allows rapid, high-resolution imaging of large samples, such as human brain slices, expanded tissues, or highly motile animals like the Hydra

Improving the Fidelity of Organoid Cell Types via Single-Cell Genomics

Jeff Karp, Benjamin Mead and colleagues use systematic single-cell analysis to generate organoid-derived intestinal cells, demonstrating a rational approach to creating faithful models of in vivo populations

Reviews in BMC Biology

Stay up to date with our authoritative Reviews from leaders in the field, on topics including the microbiome, cancer, evolution, neurobiology, cell biology and genetics

Featured Forum

Membrane dynamics and organelle biogenesis—lipid pipelines and vesicular carriers

Christopher J. Stefan, William S. Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M. Valm, Jennifer Lippincott-Schwartz, Tim P. Levine, David B. Iaea, Frederick R. Maxfield, Clare E. Futter, Emily R. Eden, Delphine Judith, Alexander R. van Vliet, Patrizia Agostinis, Sharon A. Tooze, Ayumu Sugiura and Heidi M. McBride

Published on: 31 October 2017

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Articles

Content type: Research article
| 22 June 2018

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins

Authors: Lukasz Kowalski, Piotr Bragoszewski, Anton Khmelinskii, Edyta Glow, Michael Knop and Agnieszka Chacinska

The Commentary to this article has been published in BMC Biology 2018 16:63
Content type: Commentary
| 22 June 2018

Proteasomal degradation competes with Mia40-mediated import into mitochondria

Authors: Eva Zöller, R. Todd Alexander and Johannes M. Herrmann

The original article was published in BMC Biology 2018 16:66
Content type: Research article
| 21 June 2018

Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles

Authors: Denise G. Lanza, Angelina Gaspero, Isabel Lorenzo, Lan Liao, Ping Zheng, Ying Wang, Yu Deng, Chonghui Cheng, Chuansheng Zhang, John R. Seavitt, Francesco J. DeMayo, Jianming Xu, Mary E. Dickinson, Arthur L. Beaudet and Jason D. Heaney
Content type: Research article
| 21 June 2018

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

Authors: Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon…
Content type: Research article
| 15 June 2018

Ultrastructural analysis of mitotic Drosophila S2 cells identifies distinctive microtubule and intracellular membrane behaviors

Authors: Anton Strunov, Lidiya V. Boldyreva, Evgeniya N. Andreyeva, Gera A. Pavlova, Julia V. Popova, Alena V. Razuvaeva, Alina F. Anders, Fioranna Renda, Alexey V. Pindyurin, Maurizio Gatti and Elena Kiseleva

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Research
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
Benjamin E. Mead, Jose Ordovas-Montanes, Alexandra P. Braun, Lauren E. Levy, Prerna Bhargava, Matthew J. Szucs, Dustin A. Ammendolia, Melanie A. MacMullan, Xiaolei Yin, Travis K. Hughes, Marc H. WadsworthII, Rushdy Ahmad, Seth Rakoff-Nahoum, Steven A. Carr, Robert Langer, James J. Collins, Alex K. Shalek and Jeffrey M. Karp
Published on: 5 June 2017

Methodology
Light sheet theta microscopy for rapid high-resolution imaging of large biological samples
JonatBianca Migliori, Malika S. Datta, Christophe Dupre, Mehmet C. Apak, Shoh Asano, Ruixuan Gao, Edward S. Boyden, Ola Hermanson, Rafael Yuste and Raju Tomer
Published on: 29 May 2017

Research
Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography
Jose L. Olmos Jr, Suraj Pandey, Jose M. Martin-Garcia, George Calvey, Andrea Katz, Juraj Knoska, Christopher Kupitz, Mark S. Hunter, Mengning Liang, Dominik Oberthuer, Oleksandr Yefanov, Max Wiedorn, Michael Heyman, Mark Holl, Kanupriya Pande, Anton Barty, Mitchell D. Miller, Stephan Stern, Shatabdi Roy-Chowdhury, Jesse Coe, Nirupa Nagaratnam, James Zook, Jacob Verburgt, Tyler Norwood, Ishwor Poudyal, David Xu, Jason Koglin, Matthew H. Seaberg, Yun Zhao, Saša Bajt, Thomas Grant, Valerio Mariani, Garrett Nelson, Ganesh Subramanian, Euiyoung Bae, Raimund Fromme, Russell Fung, Peter Schwander, Matthias Frank, Thomas A. White, Uwe Weierstall, Nadia Zatsepin, John Spence, Petra Fromme, Henry N. Chapman, Lois Pollack, Lee Tremblay, Abbas Ourmazd, George N. Phillips Jr and Marius Schmidt
Published on: 31 May 2018

Research
Comparative genomics of the miniature wasp and pest control agent Trichogramma pretiosum
Amelia R. I. Lindsey, Yogeshwar D. Kelkar, Xin Wu, Dan Sun, Ellen O. Martinson, Zhichao Yan, Paul F. Rugman-Jones, Daniel S. T. Hughes, Shwetha C. Murali, Jiaxin Qu, Shannon Dugan, Sandra L. Lee, Hsu Chao, Huyen Dinh, Yi Han, Harsha Vardhan Doddapaneni…
Published on: 18 May 2018

Research
Small RNA profiling of low biomass samples: identification and removal of contaminants
Anna Heintz-Buschart, Dilmurat Yusuf, Anne Kaysen, Alton Etheridge, Joëlle V. Fritz, Patrick May, Carine de Beaufort, Bimal B. Upadhyaya, Anubrata Ghosal, David J. Galas and Paul Wilmes
Published on: 14 May 2018

Review
The biological function of the cellular prion protein: an update
Marie-Angela Wulf, Assunta Senatore and Adriano Aguzzi
Published on: 2 May 2017

Forum
Non-model model organisms
James J. Russell, Julie A. TheriotEmail author, Pranidhi Sood, Wallace F. MarshallEmail author, Laura F. Landweber, Lillian Fritz-Laylin, Jessica K. Polka, Snezhana Oliferenko, Therese Gerbich, Amy Gladfelter, James Umen, Magdalena Bezanilla, Madeline A. Lancaster, Shuonan He, Matthew C. Gibson, Bob Goldstein, Elly M. Tanaka, Chi-Kuo Hu and Anne Brunet
Published on: 29 June 2017

Review
Meta-evaluation of meta-analysis: ten appraisal questions for biologists
Shinichi Nakagawa, Daniel W. A. Noble, Alistair M. Senior and Malgorzata Lagisz
Published on: 3 March 2017

Opinion
Towards a Dynamic Interaction Network of Life to unify and expand the evolutionary theory
Eric Bapteste and Philippe Huneman
Published on: 29 May 2018

Review
Antibiotic resistance: it’s bad, but why isn’t it worse?
Nicholas Waglechner and Gerard D. Wright
Published on: 15 September 2017

Content type: Research article
| 24 September 2009

scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Authors: Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson and Anthony M Brumby
Content type: Review
| 28 October 2011

Molecular dynamics simulations and drug discovery

Authors: Jacob D Durrant and J Andrew McCammon
Content type: Question and Answer
| 30 September 2011

Q&A: What is the Golgi apparatus, and why are we asking?

Authors: Sean Munro
Content type: Research article
| 23 November 2009

Mapping cortical hubs in tinnitus

Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz
Content type: Forum
| 14 December 2012

What determines cell size?

Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

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BMC Biology is a broad scope journal covering all areas of biology. Our content includes research articles, new methods and tools. BMC Biology also publishes reviews, Q&A, and commentaries.