BMC Biology

Fifteen Years of BMC Biology

To mark our fifteen-year anniversary, in this special collection we bring together pieces from a selection of the authors, reviewers, and editorial board members who have been part of our journey, sharing their stories and perspectives

A New Cyclops Emerges from Algae

Armin Hallmann, Georg Nagel and colleagues report a novel opsin family from green algae, showing that these light-inhibited guanylyl cyclases are regulated through a two-component-like phosphoryl transfer, naming them “two-component cyclase opsins” (2c-Cyclops)

Bacterial Proteins in Evolving Mitochondria

Pavel Dolezal and colleagues map mitochondrial TAT translocases in diverse eukaryotic lineages and determine how these bacterial-derived proteins contribute to protein transport during mitochondrial evolution

Respiratory Chain Supercomplexes

Our EBM Judy Hirst discusses the functional and structural features of the supramolecular assemblies of respiratory enzymes known as supercomplexes, and the advantages they may confer to mitochondrial respiration

Call for Papers – "Engineering Biology" series

We are delighted to invite submission of Research papers to our latest series, under the Guest Editorship of James Collins, Sophien Kamoun, Nicola Patron, James Wells, and Pamela Silver. For more details, please read here!

Call for Papers – special issue on Cancer Metabolism

We are now inviting submissions of Research papers for our cross-journal special issue. Guest Editors: Navdeep Chandel, Matthew Vander Heiden, Karen Vousden and Kathryn Wellen. Read more here!

Featured Commentary

Genome of tiny predator with big appetite

Geoffrey Ian McFadden

Published on: 28 November 2018

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Articles

Content type: Research article
| 6 December 2018

Two-component cyclase opsins of green algae are ATP-dependent and light-inhibited guanylyl cyclases

Authors: Yuehui Tian, Shiqiang Gao, Eva Laura von der Heyde, Armin Hallmann and Georg Nagel
Content type: Research article
| 28 November 2018

Nuclear genome sequence of the plastid-lacking cryptomonad Goniomonas avonlea provides insights into the evolution of secondary plastids

Authors: Ugo Cenci, Shannon J. Sibbald, Bruce A. Curtis, Ryoma Kamikawa, Laura Eme, Daniel Moog, Bernard Henrissat, Eric Maréchal, Malika Chabi, Christophe Djemiel, Andrew J. Roger, Eunsoo Kim and John M. Archibald

The Commentary to this article has been published in BMC Biology 2018 16:140
Content type: Research article
| 28 November 2018

Detecting neural assemblies in calcium imaging data

Authors: Jan Mölter, Lilach Avitan and Geoffrey J. Goodhill
Content type: Commentary
| 28 November 2018

Genome of tiny predator with big appetite

Authors: Geoffrey Ian McFadden

The original article was published in BMC Biology 2018 16:137
Content type: Research article
| 26 November 2018

Migration through a small pore disrupts inactive chromatin organization in neutrophil-like cells

Authors: Elsie C. Jacobson, Jo K. Perry, David S. Long, Ada L. Olins, Donald E. Olins, Bryon E. Wright, Mark H. Vickers and Justin M. O’Sullivan

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Research
Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication
Amanda L. Pendleton, Feichen Shen, Angela M. Taravella, Sarah Emery, Krishna R. Veeramah, Adam R. Boyko and Jeffrey M. Kidd
Published on: 28 June 2018

Research
Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes
Pauline Salis, Natacha Roux, Olivier Soulat, David Lecchini, Vincent Laudet and Bruno Frédérich
Published on: 05 September 2018

Research
Nuclear genome sequence of the plastid-lacking cryptomonad Goniomonas avonlea provides insights into the evolution of secondary plastids
Ugo Cenci, Shannon J. Sibbald, Bruce A. Curtis, Ryoma Kamikawa, Laura Eme, Daniel Moog, Bernard Henrissat, Eric Maréchal, Malika Chabi, Christophe Djemiel, Andrew J. Roger, Eunsoo Kim and John M. Archibald
Published on: 28 November 2018

Research
Evolution of mitochondrial TAT translocases illustrates the loss of bacterial protein transport machines in mitochondria
Markéta Petrů, Jeremy Wideman, Kristoffer Moore, Felicity Alcock, Tracy Palmer and Pavel Doležal
Published on: 22 November 2018

Research
Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida
Sunjoo Joo, Ming Hsiu Wang, Gary Lui, Jenny Lee, Andrew Barnas, Eunsoo Kim, Sebastian Sudek, Alexandra Z. Worden and Jae-Hyeok Lee
Published on: 5 November 2018

Open Questions
Open questions: CRISPR biology
Eugene V. Koonin
Published on: 24 September 2018

Interview
From plant immunity to food security: an interview with Ksenia Krasileva
Ksenia Krasileva
Published on: 1 November 2018

Interview
Studying the microbiome and its complexities: an interview with Alan Walker
Alan Walker
Published on: 1 November 2018

Open Questions
Open questions: why are babies rarely born with cancer?
Michelle Monje
Published on: 1 November 2018

Interview
When a physicist wanders into biology…: an interview with KC Huang
Kerwyn Casey Huang
Published on: 1 November 2018

Content type: Research article
| 24 September 2009

scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Authors: Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson and Anthony M Brumby
Content type: Review
| 28 October 2011

Molecular dynamics simulations and drug discovery

Authors: Jacob D Durrant and J Andrew McCammon
Content type: Question and Answer
| 30 September 2011

Q&A: What is the Golgi apparatus, and why are we asking?

Authors: Sean Munro
Content type: Research article
| 23 November 2009

Mapping cortical hubs in tinnitus

Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz
Content type: Research article
| 12 November 2014

Reagent and laboratory contamination can critically impact sequence-based microbiome analyses

Authors: Susannah J Salter, Michael J Cox, Elena M Turek, Szymon T Calus, William O Cookson, Miriam F Moffatt, Paul Turner, Julian Parkhill, Nicholas J Loman and Alan W Walker

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Focus: Genome Editing

Read the latest Reviews on genome editing across BMC flagship journals.

Genome editing for inborn errors of metabolism: advancing towards the clinic
Jessica L. Schneller, Ciaran M. Lee, Gang Bao and Charles P. Venditti
Published in BMC Medicine on: 27 February 2017

Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins
Yuwei Zhu, Fan Zhang and Zhiwei Huang
Published in BMC Biology on: 19 March 2018

Resources for the design of CRISPR gene editing experiments
Daniel B. Graham and David E. Root
Published in Genome Biology on: 27 November 2015

Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic
Dianne Nicol, Lisa Eckstein, Michael Morrison, Jacob S. Sherkow, Margaret Otlowski, Tess Whitton, Tania Bubela, Kathryn P. Burdon, Don Chalmers, Sarah Chan, Jac Charlesworth, Christine Critchley, Merlin Crossley, Sheryl de Lacey, Joanne L. Dickinson, Alex W. Hewitt, Joanne Kamens, Kazuto Kato, Erika Kleiderman, Satoshi Kodama, John Liddicoat, David A. Mackey, Ainsley J. Newson, Jane Nielsen, Jennifer K. Wagner and Rebekah E. McWhirter
Published in Genome Medicine on: 25 September 2017