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Inactivation of CRISPR-Cas systems by anti-CRISPR proteins

In their review, Yuwei Zhu and colleagues provide an overview of anti-CRISPR protein diversity, focusing on their structure and topology, and the insights this provides into their mechanisms of inhibition

Reviews in BMC Biology

Stay up to date with our authoritative Reviews from leaders in the field, on topics including the microbiome, cancer, evolution, neurobiology, cell biology and genetics

Trait co-evolution in budding yeast

Part of our “In the Light of Evolution" series –  a look across 784 yeast species reveals how physiology and environment shapes the presence of traits, and strengthens correlations between them

Evolving dopamine transporters

Harel Weinstein and colleagues examine how functional properties of human neurotransmitter transporters emerge from bacterial homologues through evolutionary adaptation

Collections’ Highlights

From our “Protein Quality Control at Membranes” series - Sara Sannino and Jeffrey L. Brodsky provide a review on targeting protein quality control pathways in breast cancer

Video Abstract: building the bacterial flagella

A graphical summary of Fadel Samatey and colleagues’ recent paper on how intrinsically disordered regions give rise to stability of the flagella hook

Featured Review

Lipid metabolism fattens up hedgehog signaling

Robert Blassberg and John Jacob

Published on: 26 October 2017




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A software tool ‘CroCo’ detects pervasive cross-species contamination in next generation sequencing data​​​​​​​
Paul Simion, Khalid Belkhir, Clémentine François, Julien Veyssier, Jochen C. Rink, Michaël Manuel, Hervé Philippe and Maximilian J. Telford
Published on: 5 March 2018

A sophisticated, differentiated Golgi in the ancestor of eukaryotes
Lael D. Barlow, Eva Nývltová, Maria Aguilar, Jan Tachezy and Joel B. Dacks
Published on: 7 March 2018

Cell fixation and preservation for droplet-based single-cell transcriptomics
Jonathan Alles, Nikos Karaiskos, Samantha D. Praktiknjo, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks and Nikolaus Rajewsky
Published on: 19 May 2017

The landscape of sex-differential transcriptome and its consequent selection in human adults
Moran Gershoni and Shmuel Pietrokovski
Published on: 7 February 2017

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Peter J. McCormick and Rafael Franco
Published on: 28 February 2018

Nothing in cancer makes sense except…
Mel Greaves
Published on: 21 February 2018

Targeting protein quality control pathways in breast cancer
Sara Sannino and Jeffrey L. Brodsky
Published on: 16 November 2017

Measuring behavior across scales
Gordon J. Berman
Published on: 23 February 2018

The human microbiome in evolution
Emily R. Davenport, Jon G. Sanders, Se Jin Song, Katherine R. Amato, Andrew G. Clark and Rob Knight
Published on: 27 December 2017

Hormonal and environmental signals guiding stomatal development​​​​​​​
Xingyun Qi and Keiko U. Torii
Published on: 20 February 2018

  1. Content type: Research article


    Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

  2. Content type: Forum


    Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

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BMC Biology is a broad scope journal covering all areas of biology. Our content includes research articles, new methods and tools. BMC Biology also publishes reviews, Q&A, and commentaries.