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Call for Papers - "Engineering Biology" series

We are delighted to invite submission of Research papers to our latest series, under the Guest Editorship of James Collins, Sophien Kamoun, Nicola Patron, James Wells, and Pamela Silver. For more details, please read here!

A Humanized Model of Hypercholesterolemia

Mohammad Bohlooly-Y and Marcello Maresca describe a humanized mouse model with liver-specific expression of human PCSK9 and a hypercholesterolemia phenotype, showing that it can be used to evaluate antibody and gene editing-based therapies

Label-Free Multicolor Mesoscale Imaging

Sebastian Munck and colleagues develop a label-free tomography-based method that allows mesoscale 3D imaging  of non-transparent objects

Assessing Multiallelic Gene Disruption

Wai-Yee Chan, Bo Feng and colleagues investigate the potential and functional outcomes of homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in

Call for Papers – "Microbiome Biology"

BMC Biology and Genome Biology are inviting submission for our upcoming joint special issue on microbiome biology scheduled for publication in Spring 2019

A Flare for Base Editing

Matthew Coelho, Benjamin Taylor and colleagues develop a Base Editing FLuorescent Activity REporter (BE-FLARE), which allows enrichment of cells that have undergone editing of target loci, and evaluate the editing efficiency of cytidine deaminanses APOBEC3A and APOBEC3B

Featured Editorial

Tackling waste in publishing through portable peer review

Graham P. Bell and Mirna Kvajo

Published on: 17 December 2018


Biological clock function is linked to proactive and reactive personality types
Christian Tudorache, Hans Slabbekoorn, Yuri Robbers, Eline Hin, Johanna H. Meijer, Herman P. Spaink and Marcel J. M. Schaaf
Published on: 21 December 2018

Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes
Pauline Salis, Natacha Roux, Olivier Soulat, David Lecchini, Vincent Laudet and Bruno Frédérich
Published on: 05 September 2018

BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
Matthew A. Coelho, Songyuan Li, Luna Simona Pane, Mike Firth, Giovanni Ciotta, Jonathan D. Wrigley, Maria Emanuela Cuomo, Marcello Maresca and Benjamin J. M. Taylor
Published on: 28 December 2018

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways
Ziyun Wu, Megan M. Senchuk, Dylan J. Dues, Benjamin K. Johnson, Jason F. Cooper, Leira Lew, Emily Machiela, Claire E. Schaar, Heather DeJonge, T. Keith Blackwell and Jeremy M. Van Raamsdonk
Published on: 18 December 2018

Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells
Chenzi Zhang, Xiangjun He, Yvonne K. Kwok, Feng Wang, Junyi Xue, Hui Zhao, Kin Wah Suen, Chi Chiu Wang, Jianwei Ren, George G. Chen, Paul B. S. Lai, Jiangchao Li, Yin Xia, Andrew M. Chan, Wai-Yee Chan and Bo Feng
Published on: 28 December 2018

Host-parasite interactions: an interview with Emily Troemel
Emily Troemel
Published on: 1 November 2018

When a physicist wanders into biology…: an interview with KC Huang
Kerwyn Casey Huang
Published on: 1 November 2018

Open Questions
Open questions: why are babies rarely born with cancer?
Michelle Monje
Published on: 1 November 2018

Tissue macrophages: heterogeneity and functions
Siamon Gordon and Annette Plüddemann
Published on: 29 June 2017

Horizons in the evolution of aging
Thomas Flatt and Linda Partridge
Published on: 20 August 2018

  1. Content type: Research article


    Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

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Focus: Approaches to Data Analysis

Read the latest Reviews on data analysis across BMC flagship journals.

Using flawed, uncertain, proximate and sparse (FUPS) data in the context of complexity: learning from the case of child mental health
Miranda Wolpert and Harry Rutter
Published in BMC Medicine on: 18 June 2018

Meta-evaluation of meta-analysis: ten appraisal questions for biologists
Shinichi Nakagawa, Daniel W. A. Noble, Alistair M. Senior and Malgorzata Lagisz
Published in BMC Biology on: 03 March 2017

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications
Ashraful Haque, Jessica Engel, Sarah A. Teichmann and Tapio Lönnberg
Published in Genome Medicine on: 18 August 2017

From squiggle to basepair: computational approaches for improving nanopore sequencing read accuracy
Franka J. Rang, Wigard P. Kloosterman and Jeroen de Ridder
Published in Genome Biology on: 13 July 2018

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