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Targeting protein quality control pathways in breast cancer

Cancer cells thrive in stress conditions that cause protein damage. Sannino and Brodsky review the mechanisms, and how we might exploit these processes in treating breast cancer

Hybrid de novo genome assembly – the gray mouse lemur

Incorporating datasets from different genomic technologies can result in improved genome assemblies – here illustrated by the gray mouse lemur genome

Forum - Membrane dynamics and organelle biogenesis

Ten perspectives on the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth

Methodology – screening for inhibitors of protein-protein interactions

In vivo assays to screen for small-molecule inhibitors of PPIs are limited. Wong et al present a new method, characterised by a novel Mdm2-binding site in p53

Collections’ Highlights

From “In the Light of Evolution”– a Review from Waglechner and Wright on antibiotic resistance: it’s bad, but why isn’t it worse?

Research: Gershoni and Pietrokovski

“The landscape of sex-differential transcriptome and its consequent selection in human adults”

Featured Review 

Digital tissue and what it may reveal about the brain

Josh L. Morgan and Jeff W. Lichtman

Published on: 30 October 2017


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The landscape of sex-differential transcriptome and its consequent selection in human adults
Moran Gershoni and Shmuel Pietrokovski
Published on: 7 February 2017

Cell fixation and preservation for droplet-based single-cell transcriptomics
Jonathan Alles†, Nikos Karaiskos†, Samantha D. Praktiknjo†, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks and Nikolaus Rajewsky
Published on: 19 May 2017

The house spider genome reveals an ancient whole-genome duplication during arachnid evolution
Evelyn E. Schwager†, Prashant P. Sharma†, Thomas Clarke†, Daniel J. Leite†, Torsten Wierschin†, Matthias Pechmann, Yasuko Akiyama-Oda, Lauren Esposito, Jesper Bechsgaard, Trine Bilde, Alexandra D. Buffry, Hsu Chao, Huyen Dinh, HarshaVardhan Doddapaneni, Shannon Dugan, Cornelius Eibner, Cassandra G. Extavour, Peter Funch, Jessica Garb, Luis B. Gonzalez, Vanessa L. Gonzalez, Sam Griffiths-Jones, Yi Han, Cheryl Hayashi, Maarten Hilbrant, Daniel S. T. Hughes, Ralf Janssen, Sandra L. Lee, Ignacio Maeso, Shwetha C. Murali, Donna M. Muzny, Rodrigo Nunes da Fonseca, Christian L. B. Paese, Jiaxin Qu, Matthew Ronshaugen, Christoph Schomburg, Anna Schönauer, Angelika Stollewerk, Montserrat Torres-Oliva, Natascha Turetzek, Bram Vanthournout, John H. Werren, Carsten Wolff, Kim C. Worley, Gregor Bucher, Richard A. Gibbs, Jonathan Coddington, Hiroki Oda, Mario Stanke, Nadia A. Ayoub, Nikola-Michael Prpic, Jean-François Flot, Nico Posnien, Stephen Richards and Alistair P. McGregor
Published on: 31 July 2017

Sexual conflict explains the extraordinary diversity of mechanisms regulating mitochondrial inheritance
Arunas L. Radzvilavicius, Nick Lane and Andrew Pomiankowski
Published on: 26 October 2017

Spatial phylogenetics of the native California flora
Andrew H. Thornhill, Bruce G. Baldwin, William A. Freyman, Sonia Nosratinia, Matthew M. Kling, Naia Morueta-Holme, Thomas P. Madsen, David D. Ackerly and Brent D. Mishler
Published on: 26 October 2017

Antibiotic resistance: it’s bad, but why isn’t it worse?
Nicholas Waglechner and Gerard D. Wright
Published on: 15 September 2017

Splendor and misery of adaptation, or the importance of neutral null for understanding evolution
Eugene V. Koonin
Published on: 23 December 2016

Detecting positive selection in the genome
Tom R. Booker, Benjamin C. Jackson and Peter D. Keightley
Published on: 30 October 2017

Human evolution: the non-coding revolution
Lucía F. Franchini and Katherine S. Pollard
Published on: 2 October 2017

Membrane dynamics and organelle biogenesis—lipid pipelines and vesicular carriers
Christopher J. Stefan, William S. Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M. Valm, Jennifer Lippincott-Schwartz, Tim P. Levine, David B. Iaea, Frederick R. Maxfield, Clare E. Futter, Emily R. Eden, Delphine Judith, Alexander R. van Vliet, Patrizia Agostinis, Sharon A. Tooze, Ayumu Sugiura and Heidi M. McBride
Published on: 31 October 2017

  1. Content type: Research article


    Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

  2. Content type: Forum


    Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

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Aims and scope

BMC Biology is the flagship biology journal of the BMC series, pioneer of open access publishing. Our scope includes research and methodology articles, review, Q&A and comment, across all of biology and with a publication policy that combines selection for special interest and importance with a commitment to serving authors well.

Latest collections

Thematic series
Protein Quality Control at Membranes
BMC Biology

Thematic series
New Tools for Neurobiology
BMC Biology

Cross journal collection
In the Light of Evolution

Thematic series
What is Wrong With This Picture?
BMC Biology

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