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How Gardenias became chemists

The genome sequence of Gardenia jasminoides yields insights into the ways gene duplications drove the divergent evolution of the crocin and caffeine biosynthetic pathways.

Dissecting the functions of acetyl-CoA in Toxoplasma Gondii

Using multi-omics approaches, Dominique Soldati-Favre and colleagues examine the role of distinct acetyl-CoA subcellular pools in the pathogen Toxoplasma gondii, identifying their distinct roles in the synthesis of parasite-specific fatty acids, and impact on metabolic processes.

The rise of metabolic diversity across the Candidate Phyla Radiation

Mapping bacterial genomes and metabolic capacities allowed the identification of the evolutionary processes driving metabolic diversity in the Candidate Phyla Radiation lineages.

The merger that made us

Buzz Baum and David Baum comment on the evolution of eukaryotic cells, and how discoveries of new microbes chart the path to eukaryogenesis.

Targeted approaches for epigenetic age predictions

DNA methylation analysis based on pyrosequencing, ddPCR, and BBA-seq approaches enables high-precision epigenetic age-predictions and demonstrated that the stochastic evolution of age-associated methylation patterns enables epigenetic clocks for individual DNA strands.

Call for papers: Research Synthesis and Meta-research in Biology

We’re inviting submissions to our new Series guest edited by Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod and Wolfgang Viechtbauer.

Featured Opinion

The replication machinery of LUCA: common origin of DNA replication and transcription

Eugene V. Koonin, Mart Krupovic, Sonoko Ishino and Yoshizumi Ishino.

Published 09 June 2020


Unlocking the origins and biology of domestic animals using ancient DNA and paleogenomics
Gillian P. McHugo et al.
Published 02 December 2019

Are we there yet? The long walk towards the development of efficient symbiotic associations between nitrogen-fixing bacteria and non-leguminous crops
Vânia C. S. Pankievicz et al.
Published 03 December 2019

The microbiome of the upper respiratory tract in health and disease
Christina Kumpitsch, Kaisa Koskinen, Veronika Schöpf & Christine Moissl-Eichinger
Published: 07 November 2019

The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health
Jillian L. Waters & Ruth E. Ley
Published: 28 October 2019

Studying the gut virome in the metagenomic era: challenges and perspectives
Sanzhima Garmaeva, Trishla Sinha, Alexander Kurilshikov, Jingyuan Fu, Cisca Wijmenga & Alexandra Zhernakova
Published: 28 October 2019

  1. Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

    Content type: Research article

Focus: Cancer

Read the latest papers on cancer across BMC flagship journals.

Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
Heinz Freisling et al.

Published in BMC Medicine 10 January 2020

Joint learning improves protein abundance prediction in cancers
Hongyang Li et al.

Published in BMC Biology 23 December 2019

Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines
Hang Ruan et al.

Published in Genome Medicine 26 August 2019

Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures
Oguzhan Begik et al.

Published in Genome Biology 07 May 2020

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Announcement: COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.