Skip to content


Call for Papers – "Engineering Biology" series

We are delighted to invite submission of Research papers to our latest series, under the Guest Editorship of James Collins, Sophien Kamoun, Nicola Patron, James Wells, and Pamela Silver. For more details, please read here!

Call for Papers – Special Issue on Cancer Metabolism

We are now inviting submissions of Research papers for our cross-journal special issue. Guest Editors: Navdeep Chandel, Matthew Vander Heiden, Karen Vousden and Kathryn Wellen; submission deadline - October 31st 2018. Read more here!

How Transposons Convey Stress Tolerance

Andrea Sánchez-Vallet and colleagues show that transposable elements convey tolerance to fungicides to the wheat pathogen Zymoseptoria tritici by modulating its melanin levels

A Structural View of a Co-Chaperone

Rivka Isaacson and colleagues analyze the structure of the co-chaperone SGTA, identifying the regions that are involved in the processing of its substrates

Drivers of Preplacodal Ectoderm Specification

Gerhard Schlosser and colleagues identify the gene regulatory network and functional interactions among transcription factors underlying the specification of the preplacodal ectoderm in Xenopus

Targeting HIV via CRISPR/Cas9

Keith Jerome and colleagues describe a strategy for designing guide RNAs for targeting the HIV virus via CRISPR/Cs9 that takes into account the genetic diversity of the viral populations

Featured Opinion

Towards a Dynamic Interaction Network of Life to unify and expand the evolutionary theory

Eric Bapteste and Philippe Huneman

Published on: 29 May 2018




Featured Videos​​​​​​​

Stay up to date with our authoritative Reviews, lively Q&As, and current Opinion articles


Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication
Amanda L. Pendleton, Feichen Shen, Angela M. Taravella, Sarah Emery, Krishna R. Veeramah, Adam R. Boyko and Jeffrey M. Kidd
Published on: 28 June 2018

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants
Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon, Loranne Agius, Quentin M. Anstee, Kirill E. Volynski, Dimitri M. Kullmann, Sara Wells and Lydia Teboul
Published on: 21 June 2018

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins
Lukasz Kowalski, Piotr Bragoszewski, Anton Khmelinskii, Edyta Glow, Michael Knop and Agnieszka Chacinska
Published on: 22 June 2018

Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles
Denise G. Lanza, Angelina Gaspero, Isabel Lorenzo, Lan Liao, Ping Zheng, Ying Wang, Yu Deng, Chonghui Cheng, Chuansheng Zhang, John R. Seavitt, Francesco J. DeMayo, Jianming Xu, Mary E. Dickinson, Arthur L. Beaudet and Jason D. Heaney
Published on: 21 June 2018

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
Benjamin E. Mead, Jose Ordovas-Montanes, Alexandra P. Braun, Lauren E. Levy, Prerna Bhargava, Matthew J. Szucs, Dustin A. Ammendolia, Melanie A. MacMullan, Xiaolei Yin, Travis K. Hughes, Marc H. WadsworthII, Rushdy Ahmad, Seth Rakoff-Nahoum, Steven A. Carr, Robert Langer, James J. Collins, Alex K. Shalek and Jeffrey M. Karp
Published on: 5 June 2017

Towards a Dynamic Interaction Network of Life to unify and expand the evolutionary theory
Eric Bapteste and Philippe Huneman
Published on: 29 May 2018

Proteasomal degradation competes with Mia40-mediated import into mitochondria
Eva Zöller, R. Todd Alexander and Johannes M. Herrmann
Published on: 22 June 2018

Tissue macrophages: heterogeneity and functions
Siamon Gordon and Annette Plüddemann
Published on: 29 June 2017

Q&A: Expansion microscopy
Ruixuan Gao, Shoh M. Asano and Edward S. Boyden
Published on: 19 June 2017

Synaptopathy, circuitopathy and the computational biology of Huntington’s disease
Anthony J. Hannan
Published on: 27 June 2018

  1. Content type: Research article


    Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

  2. Content type: Forum


    Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

Most accessed articles RSS

View all articles

Focus On: Neurobiology

Read the latest Reviews covering the development, function and pathology of the brain

The biological function of the cellular prion protein: an update
Marie-Angela Wulf, Assunta Senatore and Adriano Aguzzi
Published on: 2 May 2017

Examining non-LTR retrotransposons in the context of the evolving primate brain
Sara B. Linker, Maria C. Marchetto, Iñigo Narvaiza, Ahmet M. Denli and Fred H. Gage
Published on: 11 August 2017

Digital tissue and what it may reveal about the brain
Josh L. Morgan and Jeff W. Lichtman
Published on: 30 October 2017

Measuring behaviour across scales
Gordon J. Berman
Published on: 23 February 2018

Latest collections

Thematic series
Environment and Sustainability
BMC Biology

Thematic series
Protein Quality Control at Membranes
BMC Biology

Thematic series
New Tools for Neurobiology
BMC Biology

Cross journal collection
In the Light of Evolution

Thematic series
What is Wrong With This Picture?
BMC Biology

View all collections

Latest Tweets