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Deep learning about neurodegeneration

Adriana San Miguel and colleagues develop a deep learning algorithm to examine complex neurodegenerative patterns in C. elegans, showing distinct morphologies associated with aging or environmental insults.

Brain-wide sensory responses in a fragile X model

Gilles Vanwalleghem, Ethan Scott and colleagues recorded brain-wide neuronal responses at a cellular resolution to visual and auditory stimuli in a zebrafish model of the fragile X syndrome, modelling alterations of sensory networks that underlie the sensory aspects of fragile X syndrome and autism.

Uncoupling of mutations and malignant transformation in CRC

Soulafa Mamlouk, Hendrik Bläker and colleagues analyzed the genetic profiles of colorectal cancer carcinomas and their precursors to assess the timing and heterogeneity of driver mutations, showing that malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression.

How glia regulate lifespan

Linda Partridge and colleagues determine the contributions of distinct glial subpopulations to insulin-like signaling, and their role in the organism-wide modulation of development and lifespan in Drosophila.

Crowdsourcing for new antibiotics

Marek Mutwil and colleagues used crowdsourcing to identify novel components of protein synthesis in bacteria, with 285 undergraduate students processing 26.38 terabytes of RNA-seq data, and predicting more than 100 putative regulators of protein synthesis in 17 bacterial pathogens.

Call for papers: Research Synthesis and Meta-research in Biology

We’re inviting submissions to our new Series guest edited by Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod and Wolfgang Viechtbauer.

Featured Comment

Impact of COVID-19 on early career scientists: an optimistic guide for the future

Christina M. Termini & David Traver

Published 30 July 2020

Articles

  1. Authors: Karla J. Suchacki, Nicholas M. Morton, Calvin Vary, Carmen Huesa, Manisha C. Yadav, Benjamin J. Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E. Barrios-Llerena, Anyonya R. Guntur, Zohreh Khavandgar, William P. Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed…

    Content type: Research article

Review
X-ray computed tomography in life sciences
Shelley D. Rawson et al.
Published 27 February 2020

Comment
The merger that made us
Buzz Baum and David Baum
Published 24 June 2020

Review
Protein assembly systems in natural and synthetic biology
Giulio Chiesa et al.
Published: 26 March 2020

Comment
Improving the usability and comprehensiveness of microbial databases​​​​​​​
Caitlin Loeffler et al.
Published: 07 April 2020


  1. Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

    Content type: Research article

  2. Authors: Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu and Adrienne HK Roeder

    Content type: Forum

Focus: Immunology in Health and Disease

Read the latest papers on immunology across BMC flagship journals.

Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection
Daniel M. Muema​​​​​​​ et al.

Published in BMC Medicine 25 March 2020

The role of T cell trafficking in CTLA-4 blockade-induced gut immunopathology​​​​​​​
Shashuang Zhang​​​​​​​​​​​​​​ et al.

Published in BMC Biology 17 March 2020

Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma​​​​​​​
Markus W. Löffler​​​​​​​​​​​​​​ et al.

Published in Genome Medicine 30 April 2019

Host-associated microbiomes are predicted by immune system complexity and climate​​​​​​​
Douglas C. Woodhams et al.

Published in Genome Biology 03 February 2020

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