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The Roots of Strigolactone Signaling

Tom Bennett and colleagues examine the evolution of the plant signaling molecules strigolactones, determining that their synthesis is more ancient than their canonical signaling, suggesting that they evolved as rhizosphere signals and recruited much later as hormonal signals.

Genetic Voltage Indicators

Rafael Yuste and colleagues review advances in the design and use of genetic voltage indicators, and how their applications in imaging membrane potential can bring about unprecedented understanding of synaptic activity in neuronal populations.

Finding Microbial Contamination in NGS Data

A computational method for profiling microbial contamination in NGS data by Kenta Nakai and colleagues, suggests that microbial contamination of laboratory reagents and environment leads to changes in gene expression and phenotypes of cell lines.

New Players in Chromosome Alignment

Jianguo Chen and Junlin Teng characterize two previously uncharacterized coiled-coil domain proteins that localize to spindles and are important K-fiber crosslinkers, demonstrating that they are required for bipolar spindle formation and chromosome alignment.

Omics of White Adipose Tissue

Lipidomic and transcriptome profiles of browning WAT presented by Tizhong Shan and colleagues demonstrates the dynamic alterations in WAT upon exposure to cold, and represent a resource for examining the process of browning in health and disease.

Cancer Metabolism Series

Our Series on Cancer Metabolism highlights advances in our understanding of cancer metabolism through commissioned Reviews and Q&As from leaders in the field.

Featured Review

Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches

Shoval Lagziel, Won Dong Lee & Tomer Shlomi

Published on: 04 July 2019

Articles

Methodology
A systematic sequencing-based approach for microbial contaminant detection and functional inference
Sung-Joon Park, Satoru Onizuka, Masahide Seki, Yutaka Suzuki, Takanori Iwata & Kenta Nakai 
Published on: 13 September 2019

Research
Functional annotation of the cattle genome through systematic discovery and characterization of chromatin states and butyrate-induced variations
Lingzhao Fang, Shuli Liu, Mei Liu, Xiaolong Kang, Shudai Lin, Bingjie Li, Erin E. Connor, Ransom L. Baldwin VI, Albert Tenesa, Li Ma, George E. Liu & Cong-jun Li
Published on: 16 August 2019

Research
Metagenomes and metatranscriptomes shed new light on the microbial-mediated sulfur cycle in a Siberian soda lake
Charlotte D. Vavourakis, Maliheh Mehrshad, Cherel Balkema, Rutger van Hall, Adrian-Ştefan Andrei, Rohit Ghai, Dimitry Y. Sorokin & Gerard Muyzer
Published on: 22 August 2019

Research
Strigolactone synthesis is ancestral in land plants, but canonical strigolactone signalling is a flowering plant innovation
Catriona H. Walker, Karen Siu-Ting, Alysha Taylor, Mary J. O’Connell & Tom Bennett
Published on: 05 September 2019

Research
Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study
Matthias Willmann, Maria J. G. T. Vehreschild, Lena M. Biehl, Wichard Vogel, Daniela Dörfel, Axel Hamprecht, Harald Seifert, Ingo B. Autenrieth & Silke Peter
Published on: 18 September 2019


Review
Synthetic Biology Goes Cell-Free
Aidan Tinafar, Katariina Jaenes & Keith Pardee
Pubished on: 8 August 2019

Review
Viral hijacking of cellular metabolism
Shivani K. Thaker, James Ch’ng & Heather R. Christofk
Published on: 18 July 2019

Comment
Multiple levels of the unknown in microbiome research
Andrew Maltez Thomas & Nicola Segata 
Published on: 12 June 2019

Review
Mitochondrial DNA: the overlooked oncogenome?
Payam A. Gammage & Christian Frezza 
Published on: 08 July 2019

Review
Genetic voltage indicators
Yuki Bando, Christiane Grimm, Victor H Cornejo & Rafael Yuste
Published on: 12 September 2019

  1. Content type: Research article

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    Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz

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Focus: Neurology in Health and Disease

Read the latest papers on Neurology across BMC flagship journals.

Clinical and cost-effectiveness of contingency management for cannabis use in early psychosis: the CIRCLE randomised clinical trial​​​​​​
Luke Sheridan Rains, Louise Marston, Mark Hinton, Steven Marwaha, Thomas Craig, David Fowler, Michael King, Rumana Z. Omar, Paul McCrone, Jonathan Spencer, Joanne Taylor, Sophie Colman, Catherine Harder, Eleanor Gilbert, Amie Randhawa, Kirsty Labuschagne, Charlotte Jones, Theodora Stefanidou, Marina Christoforou, Meghan Craig, John Strang, Tim Weaver & Sonia Johnson

Published in BMC Medicine 15 August 2019

Parkinson’s disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons
Mei Zhu, Giuseppe P. Cortese & Clarissa L. Waites

Published in BMC Biology 10 September 2018

Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer’s disease
Laura M. Winchester, John Powell, Simon Lovestone & Alejo J. Nevado-Holgado

Published in Genome Medicine 28 June 2018

Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex​​​​​​​
Zelin Liu, Yuan Ran, Changyu Tao, Sichen Li, Jian Chen & Ence Yang

Published in Genome Biology 20 May 2019

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