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Jeehyun Kwag and colleagues dissect the contributions of parvalbumin and somatostatin interneurons to hippocampal circuit dysfunction caused by amyloid β oligomers.
Natalie Elia and colleagues present a powerful, easy-to-implement tool for live-cell labeling of proteins with small, genetic code expansion-based fluorescent probes.
Elin Lundin and colleagues use in situ sequencing to reveal the spatiotemporal patterns of RNA editing during mouse brain development, identifying regional, and cell-type specific regulation.
Catherine Pears and colleagues demonstrate a role for the two-pore channel protein and intracellular Ca2+ signalling in the regulation of mTORC1 activity upon starvation.
Francisco Ciruela, Leonardo Pardo, Vicent Casadó, Sergi Ferré and colleagues show that cannabinoid-induced inhibition of glutamate release in the striatum is mediated via heterotetramer complexes of adenosine and cannabinoid receptors.
Sylvail Foissac, Elisabetta Giuffra and colleagues profile the landscape of transcription, chromatin accessibility and conformation in immune and liver cells of ruminants, pig and chicken.
Vânia C. S. Pankievicz, Thomas B. Irving, Lucas G. S. Maia & Jean-Michel Ané
Published on: 03 December 2019
Research
Genomic adaptations to chemosymbiosis in the deep-sea seep-dwelling tubeworm Lamellibrachia luymesi
Yuanning Li, Michael G. Tassia, Damien S. Waits, Viktoria E. Bogantes, Kyle T. David & Kenneth M. Halanych
Published on: 18 November 2019
Research
Single-cell reconstruction of differentiation trajectory reveals a critical role of ETS1 in human cardiac lineage commitment
Hang Ruan, Yingnan Liao, Zongna Ren, Lin Mao, Fang Yao, Peng Yu, Youqiong Ye, Zhao Zhang, Shengli Li, Hanshi Xu, Jiewei Liu, Lixia Diao, Bingying Zhou, Leng Han & Li Wang
Published on: 13 November 2019
Research
GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse
Avinash S. Gaikwad, Amanda L. Anderson, D. Jo Merriner, Anne E. O’Connor, Brendan J. Houston, R. John Aitken, Moira K. O’Bryan & Brett Nixon
Published on: 31 October 2019
Research
Regeneration in the ctenophore Mnemiopsis leidyi occurs in the absence of a blastema, requires cell division, and is temporally separable from wound healing
Julia Ramon-Mateu, S. Tori Ellison, Thomas E. Angelini & Mark Q. Martindale
Published on: 11 October 2019
Methodology
Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement
Jes Alexander, Gregory M. Findlay, Martin Kircher & Jay Shendure
Published on: 18 November 2019
Review
The microbiome of the upper respiratory tract in health and disease
Christina Kumpitsch, Kaisa Koskinen, Veronika Schöpf & Christine Moissl-Eichinger
Published: 07 November 2019
Review
The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health
Jillian L. Waters & Ruth E. Ley
Published: 28 October 2019
Review
Studying the gut virome in the metagenomic era: challenges and perspectives
Sanzhima Garmaeva, Trishla Sinha, Alexander Kurilshikov, Jingyuan Fu, Cisca Wijmenga & Alexandra Zhernakova
Published: 28 October 2019
Review
Viral hijacking of cellular metabolism
Shivani K. Thaker, James Ch’ng & Heather R. Christofk
Published: 18 July 2019
Comment
Multiple levels of the unknown in microbiome research
Andrew Maltez Thomas & Nicola Segata
Published: 12 June 2019
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HIV epidemiology among female sex workers and their clients in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions
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Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients
J. R. Bedarf et al.
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An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar
Nathan D. Grubaugh et al.
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