BMC Biology

The Roots of Strigolactone Signaling

Tom Bennett and colleagues examine the evolution of the plant signaling molecules strigolactones, determining that their synthesis is more ancient than their canonical signaling, suggesting that they evolved as rhizosphere signals and recruited much later as hormonal signals.

Genetic Voltage Indicators

Rafael Yuste and colleagues review advances in the design and use of genetic voltage indicators, and how their applications in imaging membrane potential can bring about unprecedented understanding of synaptic activity in neuronal populations.

Finding Microbial Contamination in NGS Data

A computational method for profiling microbial contamination in NGS data by Kenta Nakai and colleagues, suggests that microbial contamination of laboratory reagents and environment leads to changes in gene expression and phenotypes of cell lines.

New Players in Chromosome Alignment

Jianguo Chen and Junlin Teng characterize two previously uncharacterized coiled-coil domain proteins that localize to spindles and are important K-fiber crosslinkers, demonstrating that they are required for bipolar spindle formation and chromosome alignment.

Omics of White Adipose Tissue

Lipidomic and transcriptome profiles of browning WAT presented by Tizhong Shan and colleagues demonstrates the dynamic alterations in WAT upon exposure to cold, and represent a resource for examining the process of browning in health and disease.

Cancer Metabolism Series

Our Series on Cancer Metabolism highlights advances in our understanding of cancer metabolism through commissioned Reviews and Q&As from leaders in the field.

Featured Review

Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches

Shoval Lagziel, Won Dong Lee & Tomer Shlomi

Published on: 04 July 2019

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Articles

Content type: Research article
| 18 September 2019

Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study

Authors: Matthias Willmann, Maria J. G. T. Vehreschild, Lena M. Biehl, Wichard Vogel, Daniela Dörfel, Axel Hamprecht, Harald Seifert, Ingo B. Autenrieth and Silke Peter
Content type: Research article
| 18 September 2019

Haplotype-resolved genomes of geminivirus-resistant and geminivirus-susceptible African cassava cultivars

Authors: Joel-E. Kuon, Weihong Qi, Pascal Schläpfer, Matthias Hirsch-Hoffmann, Philipp Rogalla von Bieberstein, Andrea Patrignani, Lucy Poveda, Stefan Grob, Miyako Keller, Rie Shimizu-Inatsugi, Ueli Grossniklaus, Hervé Vanderschuren and Wilhelm Gruissem
Content type: Research article
| 17 September 2019

Cold-induced lipid dynamics and transcriptional programs in white adipose tissue

Authors: Ziye Xu, Wenjing You, Yanbing Zhou, Wentao Chen, Yizhen Wang and Tizhong Shan
Content type: Research article
| 14 September 2019

CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment

Authors: Haining Zhou, Tao Zheng, Tianning Wang, Qi Li, Fulin Wang, Xin Liang, Jianguo Chen and Junlin Teng
Content type: Methodology article
| 13 September 2019

A systematic sequencing-based approach for microbial contaminant detection and functional inference

Authors: Sung-Joon Park, Satoru Onizuka, Masahide Seki, Yutaka Suzuki, Takanori Iwata and Kenta Nakai

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Methodology
MARPLE, a point-of-care, strain-level disease diagnostics and surveillance tool for complex fungal pathogens
Guru V. Radhakrishnan, Nicola M. Cook, Vanessa Bueno-Sancho,Clare M. Lewis, Antoine Persoons, Abel Debebe Mitiku, Matthew Heaton, Phoebe E. Davey, Bekele Abeyo, Yoseph Alemayehu, AyeleBadebo, Marla Barnett, Ruth Bryant, Jeron Chatelain, Xianming Chen, Suomeng Dong, Tina Henriksson, Sarah Holdgate, Annemarie F. Justesen, Jay Kalous, Zhensheng Kang, Szymon Laczny, Jean-Paul Legoff, Driecus Lesch, Tracy Richards, Harpinder S. Randhawa, Tine Thach, Meinan Wang, Mogens S. Hovmøller, David P. Hodson & Diane G. O. Saunders
Published on: 13 August 2019

Research
Functional annotation of the cattle genome through systematic discovery and characterization of chromatin states and butyrate-induced variations
Lingzhao Fang, Shuli Liu, Mei Liu, Xiaolong Kang, Shudai Lin, Bingjie Li, Erin E. Connor, Ransom L. Baldwin VI, Albert Tenesa, Li Ma, George E. Liu & Cong-jun Li
Published on: 16 August 2019

Research
Metagenomes and metatranscriptomes shed new light on the microbial-mediated sulfur cycle in a Siberian soda lake
Charlotte D. Vavourakis, Maliheh Mehrshad, Cherel Balkema, Rutger van Hall, Adrian-Ştefan Andrei, Rohit Ghai, Dimitry Y. Sorokin & Gerard Muyzer
Published on: 22 August 2019

Research
The impact of skin care products on skin chemistry and microbiome dynamics
Amina Bouslimani, Ricardo da Silva, Tomasz Kosciolek, Stefan Janssen, Chris Callewaert, Amnon Amir, Kathleen Dorrestein, Alexey V. Melnik, Livia S. Zaramela, Ji-Nu Kim, Gregory Humphrey, Tara Schwartz, Karenina Sanders, Caitriona Brennan, Tal Luzzatto-Knaan, Gail Ackermann, Daniel McDonald, Karsten Zengler, Rob Knight & Pieter C. Dorrestein
Published on: 12 June 2019

Methodology
Rapid identification of species, sex and maturity by mass spectrometric analysis of animal faeces
Nicola B. Davidson, Natalie I. Koch, Joscelyn Sarsby, Emrys Jones, Jane L. Hurst & Robert J. Beynon
Published on: 14 August 2019

Review
Synthetic Biology Goes Cell-Free
Aidan Tinafar, Katariina Jaenes & Keith Pardee
Pubished on: 8 August 2019

Review
Viral hijacking of cellular metabolism
Shivani K. Thaker, James Ch’ng & Heather R. Christofk
Published on: 18 July 2019

Comment
Multiple levels of the unknown in microbiome research
Andrew Maltez Thomas & Nicola Segata
Published on: 12 June 2019

Review
Mitochondrial DNA: the overlooked oncogenome?
Payam A. Gammage & Christian Frezza
Published on: 08 July 2019

Review
Horizons in the evolution of aging
Thomas Flatt and Linda Partridge
Published on: 20 August 2018

Content type: Research article
| 24 September 2009

scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Authors: Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson and Anthony M Brumby
Content type: Review
| 28 October 2011

Molecular dynamics simulations and drug discovery

Authors: Jacob D Durrant and J Andrew McCammon
Content type: Question and Answer
| 30 September 2011

Q&A: What is the Golgi apparatus, and why are we asking?

Authors: Sean Munro
Content type: Research article
| 23 November 2009

Mapping cortical hubs in tinnitus

Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz
Content type: Research article
| 12 November 2014

Reagent and laboratory contamination can critically impact sequence-based microbiome analyses

Authors: Susannah J Salter, Michael J Cox, Elena M Turek, Szymon T Calus, William O Cookson, Miriam F Moffatt, Paul Turner, Julian Parkhill, Nicholas J Loman and Alan W Walker

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Focus: Cancer

Read the latest papers on the cancer across BMC flagship journals.

Tissue-infiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma
Meng-Xin Tian, Wei-Ren Liu, Han Wang, Yu-Fu Zhou, Lei Jin, Xi-Fei Jiang, Chen-Yang Tao, Zheng Tang, Pei-Yun Zhou, Yuan Fang, Wei-Feng Qu, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Wan Yee Lau, Jia Fan & Ying-Hong Shi
Published in BMC Medicine 05 June 2019

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX

Florian Bonin, Karim Taouis, Paula Azorin, Ambre Petitalot, Zakia Tariq, Sebastien Nola, Nadège Bouteille, Sandrine Tury, Sophie Vacher, Ivan Bièche, Khadija Ait Rais, Gaelle Pierron, Laetitia Fuhrmann, Anne Vincent-Salomon, Etienne Formstecher, Jacques Camonis, Rosette Lidereau, François Lallemand & Keltouma Driouch

Published in BMC Biology 02 October 2018

Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations
Elen Kristine Höglander, Silje Nord, David C. Wedge, Ole Christian Lingjærde, Laxmi Silwal-Pandit, Hedda vdL Gythfeldt, Hans Kristian Moen Vollan, Thomas Fleischer, Marit Krohn, EllenSchlitchting, Elin Borgen, Øystein Garred, Marit M. Holmen, Erik Wist, Bjørn Naume, Peter Van Loo, Anne-Lise Børresen-Dale, Olav Engebraaten & Vessela Kristensen
Published in Genome Medicine 29 November 2019

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer
Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth & Florian Markowetz
Published in Genome Biology 13 May 2019