BMC Biology

SurfCutting Cell Contours

Stéphane Verger and colleagues develop a user-friendly method that allows cell contour extraction from 3D image stacks in a high-throughput manner.

Tackling Waste in Publishing

We consider papers reviewed at other journals on the basis of existing referee reports, and share our reviews with other journals. Find out more about portable peer review at BMC Biology.

In their Opinion piece, Ida Rishal and Mike Fainzilber discuss the mechanisms through which cells coordinate cellular processes with growth to achieve the appropriate size, and propose a size-sensing mechanism operating as a combination of titration-based measurements versus spatial sensing.

A Dynamic Dynamin for Sperm Maturation

Brett Nixon and colleagues investigate epididymosomes-small extracellular vesicles that support the maturation of sperm cells by transferring proteins from the epididymis, finding that the transfer of their cargo depends on dynamin1, which relocates via membrane rafts to be ideally positioned to facilitate the uptake of proteins.

Assembly and Trafficking of Olfactory Receptors

Richard Benton and colleagues examine the mechanisms of ionotropic receptor trafficking to sensory cilia, uncovering the role of the LBD co-receptor in the control of intracellular transport, and a heterogeneity in the regulation of trafficking.

Inferring Metabolic Dependencies in Cancer

Tomer Shlomi and colleagues develop predictive models for cancer cell line-specific dependences on hundreds of metabolic genes, identifying associations between metabolic enzymes and molecular features such as cancer lineage, oncogenic mutations, and RNA expression of neighboring enzymes.

Featured Opinion

Cell size sensing—a one-dimensional solution for a three-dimensional problem?

Ida Rishal and Mike Fainzilber

Published on: 29 April 2019

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Content type: Research article
| 14 May 2019

Biological and RNA regulatory function of MOV10 in mammalian germ cells

Authors: Kaiqiang Fu, Suwen Tian, Huanhuan Tan, Caifeng Wang, Hanben Wang, Min Wang, Yuanyuan Wang, Zhen Chen, Yanfeng Wang, Qiuling Yue, Qiushi Xu, Shuya Zhang, Haixin Li, Jie Xie, Mingyan Lin, Mengcheng Luo…
Content type: Methodology article
| 9 May 2019

ImageJ SurfCut: a user-friendly pipeline for high-throughput extraction of cell contours from 3D image stacks

Authors: Özer Erguvan, Marion Louveaux, Olivier Hamant and Stéphane Verger
Content type: Research article
| 30 April 2019

Inferring cancer dependencies on metabolic genes from large-scale genetic screens

Authors: Shoval Lagziel, Won Dong Lee and Tomer Shlomi
Content type: Opinion
| 29 April 2019

Cell size sensing—a one-dimensional solution for a three-dimensional problem?

Authors: Ida Rishal and Mike Fainzilber
Content type: Research article
| 18 April 2019

Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions

Authors: Wei Zhou, Simone J. Stanger, Amanda L. Anderson, Ilana R. Bernstein, Geoffry N. De Iuliis, Adam McCluskey, Eileen A. McLaughlin, Matthew D. Dun and Brett Nixon

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Research
The golden death bacillus Chryseobacterium nematophagum is a novel matrix digesting pathogen of nematodes
Antony P. Page, Mark Roberts, Marie-Anne Félix, Derek Pickard, Andrew Page and William Weir
Published on: 28 February 2019

Research
Inferring cancer dependencies on metabolic genes from large-scale genetic screens
Shoval Lagziel, Won Dong Lee and Tomer Shlomi
Published on: 30 APril 2019

Research
Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes
Pauline Salis, Natacha Roux, Olivier Soulat, David Lecchini, Vincent Laudet and Bruno Frédérich
Published on: 5 September 2018

Research
In vivo assembly and trafficking of olfactory Ionotropic Receptors
Liliane Abuin, Lucia L. Prieto-Godino, Haiyun Pan, Craig Gutierrez, Lan Huang, Rongsheng Jin and Richard Benton
Published on: 17 April 2019

Research
Derivation of adult canine intestinal organoids for translational research in gastroenterology
Lawrance Chandra, Dana C. Borcherding, Dawn Kingsbury, Todd Atherly, Yoko M. Ambrosini, Agnes Bourgois-Mochel, Wang Yuan, Michael Kimber, Yijun Qi, Qun Wang, Michael Wannemuehler, N. Matthew Ellinwood, Elizabeth Snella, Martin Martin, Melissa Skala, David Meyerholz, Mary Estes, Martin E. Fernandez-Zapico, Albert E. Jergens, Jonathan P. Mochel and Karin Allenspach
Published on: 11 April 2019

Opinion
Cell size sensing—a one-dimensional solution for a three-dimensional problem?
Ida Rishal and Mike Fainzilber
Pubished on: 29 April 2019

Comment
Open questions: CRISPR biology
Eugene V. Koonin
Published on: 24 September 2018

Comment
Open questions: How many genes do we have?
Steven L. Salzberg
Published on: 20 August 2018

Comment
Open questions: why are babies rarely born with cancer?
Michelle Monje
Published on: 1 November 2018

Review
Horizons in the evolution of aging
Thomas Flatt and Linda Partridge
Published on: 20 August 2018

Content type: Research article
| 24 September 2009

scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Authors: Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson and Anthony M Brumby
Content type: Review
| 28 October 2011

Molecular dynamics simulations and drug discovery

Authors: Jacob D Durrant and J Andrew McCammon
Content type: Question and Answer
| 30 September 2011

Q&A: What is the Golgi apparatus, and why are we asking?

Authors: Sean Munro
Content type: Research article
| 23 November 2009

Mapping cortical hubs in tinnitus

Authors: Winfried Schlee, Nadia Mueller, Thomas Hartmann, Julian Keil, Isabel Lorenz and Nathan Weisz
Content type: Research article
| 12 November 2014

Reagent and laboratory contamination can critically impact sequence-based microbiome analyses

Authors: Susannah J Salter, Michael J Cox, Elena M Turek, Szymon T Calus, William O Cookson, Miriam F Moffatt, Paul Turner, Julian Parkhill, Nicholas J Loman and Alan W Walker

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Focus: Pathogens

Read the latest reviews on Pathogens across BMC flagship journals.

Zika vaccines and therapeutics: landscape analysis and challenges ahead
Annelies Wilder-Smith, Kirsten Vannice, Anna Durbin, Joachim Hombach, Stephen J. Thomas, Irani Thevarjan and Cameron P. Simmons
Published in BMC Medicine on: 6 June 2018

Q&A: What are pathogens, and what have they done to and for us?
Francois Balloux and Lucy van Dorp
Published in BMC Biology on: 19 October 2017

Developing Zika vaccines: the lessons for disease X
Alan D. T. Barrett
Published in Genome Medicine on: 26 June 2018

Genomic approaches for understanding dengue: insights from the virus, vector, and host
Shuzhen Sim and Martin L. Hibberd
Published in Genome Biology on: 2 March 2016