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  1. Microscopy techniques and image segmentation algorithms have improved dramatically this decade, leading to an ever increasing amount of biological images and a greater reliance on imaging to investigate biolog...

    Authors: Gustave Ronteix, Andrey Aristov, Valentin Bonnet, Sebastien Sart, Jeremie Sobel, Elric Esposito and Charles N. Baroud
    Citation: BMC Biology 2022 20:178
  2. Kinesin-3 family motors drive diverse cellular processes and have significant clinical importance. The ATPase cycle is integral to the processive motility of kinesin motors to drive long-distance intracellular...

    Authors: Pushpanjali Soppina, Nishaben Patel, Dipeshwari J. Shewale, Ashim Rai, Sivaraj Sivaramakrishnan, Pradeep K. Naik and Virupakshi Soppina
    Citation: BMC Biology 2022 20:177
  3. Calmodulin (CaM) is an evolutionarily conserved eukaryotic multifunctional protein that functions as the major sensor of intracellular calcium signaling. Its calcium-modulated function regulates the activity o...

    Authors: Corentin Léger, Irène Pitard, Mirko Sadi, Nicolas Carvalho, Sébastien Brier, Ariel Mechaly, Dorothée Raoux-Barbot, Maryline Davi, Sylviane Hoos, Patrick Weber, Patrice Vachette, Dominique Durand, Ahmed Haouz, J. Iñaki Guijarro, Daniel Ladant and Alexandre Chenal
    Citation: BMC Biology 2022 20:176
  4. Cyanobacteria are the major prokaryotic primary producers occupying a range of aquatic habitats worldwide that differ in levels of salinity, making them a group of interest to study one of the major unresolved...

    Authors: Pedro J. Cabello-Yeves, Cristiana Callieri, Antonio Picazo, Lena Schallenberg, Paula Huber, Juan J. Roda-Garcia, Maciej Bartosiewicz, Olga I. Belykh, Irina V. Tikhonova, Alberto Torcello-Requena, Paula Martin De Prado, Richard J. Puxty, Andrew D. Millard, Antonio Camacho, Francisco Rodriguez-Valera and David J. Scanlan
    Citation: BMC Biology 2022 20:175
  5. High-throughput live-cell imaging is a powerful tool to study dynamic cellular processes in single cells but creates a bottleneck at the stage of data analysis, due to the large amount of data generated and li...

    Authors: Francesco Padovani, Benedikt Mairhörmann, Pascal Falter-Braun, Jette Lengefeld and Kurt M. Schmoller
    Citation: BMC Biology 2022 20:174
  6. Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homologue chromatids. The allelic changes are typically restricted to one or few SNPs, whic...

    Authors: Bernett Lee, Samantha Leeanne Cyrill, Wendy Lee, Rossella Melchiotti, Anand Kumar Andiappan, Michael Poidinger and Olaf Rötzschke
    Citation: BMC Biology 2022 20:173
  7. ATP-dependent chromatin remodeling complexes are multi-protein machines highly conserved across eukaryotic genomes. They control sliding and displacing of the nucleosomes, modulating histone-DNA interactions a...

    Authors: Giovanni Messina, Yuri Prozzillo, Francesca Delle Monache, Maria Virginia Santopietro and Patrizio Dimitri
    Citation: BMC Biology 2022 20:172
  8. The high-mobility group Hmga family of proteins are non-histone chromatin-interacting proteins which have been associated with a number of nuclear functions, including heterochromatin formation, replication, r...

    Authors: Giuseppina Divisato, Andrea M. Chiariello, Andrea Esposito, Pietro Zoppoli, Federico Zambelli, Maria Antonietta Elia, Graziano Pesole, Danny Incarnato, Fabiana Passaro, Silvia Piscitelli, Salvatore Oliviero, Mario Nicodemi, Silvia Parisi and Tommaso Russo
    Citation: BMC Biology 2022 20:171
  9. Neuropsychiatric disorders, such as schizophrenia (SZ) and autism spectrum disorder (ASD), are common, multi-factorial and multi-symptomatic disorders. Ample evidence implicates oxidative stress, deficient rep...

    Authors: Flavia S. Mueller, René Amport, Tina Notter, Sina M. Schalbetter, Han-Yu Lin, Zuzana Garajova, Parisa Amini, Ulrike Weber-Stadlbauer and Enni Markkanen
    Citation: BMC Biology 2022 20:170
  10. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing ...

    Authors: Daniel Oehler, André Spychala, Axel Gödecke, Alexander Lang, Norbert Gerdes, Jorge Ruas, Malte Kelm, Julia Szendroedi and Ralf Westenfeld
    Citation: BMC Biology 2022 20:169
  11. Chimeras are genetically mixed entities resulting from the fusion of two or more conspecifics. This phenomenon is widely distributed in nature and documented in a variety of animal and plant phyla. In corals, ...

    Authors: Jeremie Vidal-Dupiol, Erwan Harscouet, Dor Shefy, Eve Toulza, Olivier Rey, Jean-François Allienne, Guillaume Mitta and Baruch Rinkevich
    Citation: BMC Biology 2022 20:167
  12. Yunnan is located in Southwest China and consists of great cultural, linguistic, and genetic diversity. However, the genomic diversity of ethnic minorities in Yunnan is largely under-investigated. To gain insi...

    Authors: Zhaoqing Yang, Hao Chen, Yan Lu, Yang Gao, Hao Sun, Jiucun Wang, Li Jin, Jiayou Chu and Shuhua Xu
    Citation: BMC Biology 2022 20:166
  13. Enhancers are cis-regulatory elements present in eukaryote genomes, which constitute indispensable determinants of gene regulation by governing the spatiotemporal and quantitative expression dynamics of target...

    Authors: Ying Zhang, Meng Tang, Mengling Huang, Jiatao Xie, Jiasen Cheng, Yanping Fu, Daohong Jiang, Xiao Yu and Bo Li
    Citation: BMC Biology 2022 20:165
  14. Mitochondria have an essential role in regulating metabolism and integrate environmental and physiological signals to affect processes such as cellular bioenergetics and response to stress. In the metabolicall...

    Authors: Adam J. Trewin, Jessica Silver, Hayley T. Dillon, Paul A. Della Gatta, Lewan Parker, Danielle S. Hiam, Yin Peng Lee, Mark Richardson, Glenn D. Wadley and Séverine Lamon
    Citation: BMC Biology 2022 20:164
  15. Aggressive cancers commonly ferment glucose to lactic acid at high rates, even in the presence of oxygen. This is known as aerobic glycolysis, or the “Warburg Effect.” It is widely assumed that this is a conse...

    Authors: Shonagh Russell, Liping Xu, Yoonseok Kam, Dominique Abrahams, Bryce Ordway, Alex S. Lopez, Marilyn M. Bui, Joseph Johnson, Tamir Epstein, Epifanio Ruiz, Mark C. Lloyd, Pawel Swietach, Daniel Verduzco, Jonathan Wojtkowiak and Robert J. Gillies
    Citation: BMC Biology 2022 20:163
  16. Ubiquitination is a post-translational modification required for a number of physiological functions regulating protein homeostasis, such as protein degradation. The endoplasmic reticulum (ER) quality control ...

    Authors: Kaori Nozawa, Yoshitaka Fujihara, Darius J. Devlin, Ricardo E. Deras, Katarzyna Kent, Irina V. Larina, Kohei Umezu, Zhifeng Yu, Courtney M. Sutton, Qiuji Ye, Laura K. Dean, Chihiro Emori, Masahito Ikawa, Thomas X. Garcia and Martin M. Matzuk
    Citation: BMC Biology 2022 20:161
  17. In many organisms, aging is characterized by a loss of mitochondrial homeostasis. Multiple factors such as respiratory metabolism, mitochondrial fusion/fission, or mitophagy have been linked to cell longevity,...

    Authors: Montserrat Vega, David Castillo, Laura de Cubas, Yirong Wang, Ying Huang, Elena Hidalgo and Margarita Cabrera
    Citation: BMC Biology 2022 20:160
  18. Various mammalian species emit ultrasonic vocalizations (USVs), which reflect their emotional state and mediate social interactions. USVs are usually analyzed by manual or semi-automated methodologies that cat...

    Authors: Shai Netser, Guy Nahardiya, Gili Weiss-Dicker, Roei Dadush, Yizhaq Goussha, Shanah Rachel John, Mor Taub, Yuval Werber, Nir Sapir, Yossi Yovel, Hala Harony-Nicolas, Joseph D. Buxbaum, Lior Cohen, Koby Crammer and Shlomo Wagner
    Citation: BMC Biology 2022 20:159
  19. In a broad variety of species, muscle contraction is controlled at the neuromuscular junction (NMJ), the peripheral synapse composed of a motor nerve terminal, a muscle specialization, and non-myelinating term...

    Authors: Francisca Bermedo-García, Diego Zelada, Esperanza Martínez, Lucía Tabares and Juan Pablo Henríquez
    Citation: BMC Biology 2022 20:158
  20. Hoverflies (Diptera: Syrphidae) including Eupeodes corollae are important insects worldwide that provide dual ecosystem services including pest control and pollination. The larvae are dominant predators of aphids...

    Authors: He Yuan, Bojia Gao, Chao Wu, Lei Zhang, Hui Li, Yutao Xiao and Kongming Wu
    Citation: BMC Biology 2022 20:157
  21. Sex chromosomes are typically viewed as having originated from a pair of autosomes, and differentiated as the sex-limited chromosome (e.g. Y) has degenerated by losing most genes through cessation of recombina...

    Authors: Aivars Cīrulis, Bengt Hansson and Jessica K. Abbott
    Citation: BMC Biology 2022 20:156
  22. According to Waddington’s epigenetic landscape concept, the differentiation process can be illustrated by a cell akin to a ball rolling down from the top of a hill (proliferation state) and crossing furrows be...

    Authors: Souad Zreika, Camille Fourneaux, Elodie Vallin, Laurent Modolo, Rémi Seraphin, Alice Moussy, Elias Ventre, Matteo Bouvier, Anthony Ozier-Lafontaine, Arnaud Bonnaffoux, Franck Picard, Olivier Gandrillon and Sandrine Gonin-Giraud
    Citation: BMC Biology 2022 20:155
  23. Archaea play fundamental roles in the environment, for example by methane production and consumption, ammonia oxidation, protein degradation, carbon compound turnover, and sulfur compound transformations. Rece...

    Authors: Raphaël Méheust, Cindy J. Castelle, Alexander L. Jaffe and Jillian F. Banfield
    Citation: BMC Biology 2022 20:154
  24. Human babesiosis, caused by parasites of the genus Babesia, is an emerging and re-emerging tick-borne disease that is mainly transmitted by tick bites and infected blood transfusion. Babesia duncani has caused ma...

    Authors: Jinming Wang, Kai Chen, Jifei Yang, Shangdi Zhang, Youquan Li, Guangyuan Liu, Jianxun Luo, Hong Yin, Guangying Wang and Guiquan Guan
    Citation: BMC Biology 2022 20:153
  25. Differences in morphology, ecology, and behavior through ontogeny can result in opposing selective pressures at different life stages. Most animals, however, transition through two or more distinct phenotypic ...

    Authors: Ryan K. Schott, Rayna C. Bell, Ellis R. Loew, Kate N. Thomas, David J. Gower, Jeffrey W. Streicher and Matthew K. Fujita
    Citation: BMC Biology 2022 20:138
  26. Vertebrates develop their peripheral nervous system (PNS) from transient unique embryonic structures, the neural crest, and the ectodermal placodes that are located at the border of the forming central nervous...

    Authors: Rafath Chowdhury, Agnès Roure, Yann le Pétillon, Hélène Mayeur, Vladimir Daric and Sébastien Darras
    Citation: BMC Biology 2022 20:152
  27. Colorectal cancer, one of the most common malignancies worldwide, is associated with a high mortality rate, mainly caused by metastasis. Comparative metagenome-wide association analyses of healthy individuals ...

    Authors: Evelien Wynendaele, Nathan Debunne, Yorick Janssens, Anton De Spiegeleer, Frederick Verbeke, Liesa Tack, Sophie Van Welden, Evy Goossens, Daniel Knappe, Ralf Hoffmann, Christophe Van De Wiele, Debby Laukens, Peter Van Eenoo, Lars Vereecke, Filip Van Immerseel, Olivier De Wever…
    Citation: BMC Biology 2022 20:151
  28. Age-related hearing loss is a common, heterogeneous disease with a strong genetic component. More than 100 loci have been reported to be involved in human hearing impairment to date, but most of the genes unde...

    Authors: Morag A. Lewis, Bradley A. Schulte, Judy R. Dubno and Karen P. Steel
    Citation: BMC Biology 2022 20:150
  29. Fungi use light as an environmental signal to regulate developmental transitions that are key aspects of their biological cycles and that are also relevant for their dispersal and infectivity as plant or anima...

    Authors: María del Mar Gil-Sánchez, Sara Cea-Sánchez, Eva M. Luque, David Cánovas and Luis M. Corrochano
    Citation: BMC Biology 2022 20:149
  30. Venoms are ecological innovations that have evolved numerous times, on each occasion accompanied by the co-evolution of specialised morphological and behavioural characters for venom production and delivery. T...

    Authors: Taline D. Kazandjian, Brett R. Hamilton, Samuel D. Robinson, Steven R. Hall, Keirah E. Bartlett, Paul Rowley, Mark C. Wilkinson, Nicholas R. Casewell and Eivind A. B. Undheim
    Citation: BMC Biology 2022 20:148
  31. Type I polyketide synthases (PKSs) are multifunctional enzymes responsible for the biosynthesis of a group of diverse natural compounds with biotechnological and pharmaceutical interest called polyketides. The...

    Authors: Cécile Bon, Stéphanie Cabantous, Sylviane Julien, Valérie Guillet, Christian Chalut, Julie Rima, Yoann Brison, Wladimir Malaga, Angelique Sanchez-Dafun, Sabine Gavalda, Annaïk Quémard, Julien Marcoux, Geoffrey S. Waldo, Christophe Guilhot and Lionel Mourey
    Citation: BMC Biology 2022 20:147
  32. Escherichia coli (E. coli) has been one of the most studied model organisms in the history of life sciences. Initially thought just to be commensal bacteria, E. coli has shown wide phenotypic diversity including...

    Authors: Erwin Tantoso, Birgit Eisenhaber, Miles Kirsch, Vladimir Shitov, Zhiya Zhao and Frank Eisenhaber
    Citation: BMC Biology 2022 20:146
  33. The establishment of tissue architecture requires coordination between distinct processes including basement membrane assembly, cell adhesion, and polarity; however, the underlying mechanisms remain poorly und...

    Authors: Adnan Mahly, Krishnanand Padmanabhan, Arad Soffer, Jonathan Cohen, Jana Omar, Ronit Sagi-Eisenberg and Chen Luxenburg
    Citation: BMC Biology 2022 20:145
  34. Zika virus (ZIKV) and dengue virus (DENV) cause microcephaly and dengue hemorrhagic fever, respectively, leading to severe problems. No effective antiviral agents are approved against infections of these flavi...

    Authors: Yaning Gao, Wanbo Tai, Xinyi Wang, Shibo Jiang, Asim K. Debnath, Lanying Du and Shizhong Chen
    Citation: BMC Biology 2022 20:143
  35. Circadian rhythms are important for all aspects of biology; virtually every aspect of biological function varies according to time of day. Although this is well known, variation across the day is also often ig...

    Authors: Randy J. Nelson, Jacob R. Bumgarner, Jennifer A. Liu, Jharnae A. Love, O. Hecmarie Meléndez-Fernández, Darius D. Becker-Krail, William H. Walker II, James C. Walton, A. Courtney DeVries and Brian J. Prendergast
    Citation: BMC Biology 2022 20:142
  36. DNA methylation is involved in the epigenetic regulation of gene expression during developmental processes and is primarily established by the DNA methyltransferase 3A (DNMT3A) and 3B (DNMT3B). DNMT3A is one of t...

    Authors: Olivia Cypris, Julia Franzen, Joana Frobel, Philipp Glück, Chao-Chung Kuo, Stephani Schmitz, Selina Nüchtern, Martin Zenke and Wolfgang Wagner
    Citation: BMC Biology 2022 20:141
  37. Animal locomotion requires dynamic interactions between neural circuits, the body (typically muscles), and surrounding environments. While the neural circuitry of movement has been intensively studied, how the...

    Authors: Xiyang Sun, Yingtao Liu, Chang Liu, Koichi Mayumi, Kohzo Ito, Akinao Nose and Hiroshi Kohsaka
    Citation: BMC Biology 2022 20:130
  38. As the most abundant epigenetic modification of eukaryotic mRNA, N6-methyladenosine (m6A) modification has been shown to play a role in mammalian nervous system development and function by regulating mRNA synt...

    Authors: Yeming Yang, Ping Shuai, Xiao Li, Kuanxiang Sun, Xiaoyan Jiang, Wenjing Liu, Weidong Le, Haisong Jiang, Yuping Liu and Xianjun Zhu
    Citation: BMC Biology 2022 20:140
  39. Peach (Prunus persica) is an economically important stone fruit crop in Rosaceae and widely cultivated in temperate and subtropical regions, emerging as an excellent material to study the interaction between plan...

    Authors: Ke Cao, Zhen Peng, Xing Zhao, Yong Li, Kuozhan Liu, Pere Arus, Weichao Fang, Changwen Chen, Xinwei Wang, Jinlong Wu, Zhangjun Fei and Lirong Wang
    Citation: BMC Biology 2022 20:139
  40. β-1,4-endoglucanase (EG) is one of the three types of cellulases used in cellulose saccharification during lignocellulosic biofuel/biomaterial production. GsCelA is an EG secreted by the thermophilic bacterium Ge...

    Authors: Mei-Huey Wu, Mu-Rong Kao, Chen-Wei Li, Su-May Yu and Tuan-Hua David Ho
    Citation: BMC Biology 2022 20:137
  41. Gene expression programs are intimately linked to the interplay of active cis regulatory elements mediated by chromatin contacts and associated RNAs. Genome-wide association studies (GWAS) have identified many va...

    Authors: Jingjin Li, Yue Xiang, Lu Zhang, Xiaolong Qi, Zhuqing Zheng, Peng Zhou, Zhenshuang Tang, Yi Jin, Qiulin Zhao, Yuhua Fu, Yunxia Zhao, Xinyun Li, Liangliang Fu and Shuhong Zhao
    Citation: BMC Biology 2022 20:136
  42. Symbiotic ant-plant associations, in which ants live on plants, feed on plant-provided food, and protect host trees against threats, are ubiquitous across the tropics, with the Azteca-Cecropia associations being ...

    Authors: Maximilian Nepel, Josephine Pfeifer, Felix B. Oberhauser, Andreas Richter, Dagmar Woebken and Veronika E. Mayer
    Citation: BMC Biology 2022 20:135
  43. The mammalian X and Y chromosomes originated from a pair of ordinary autosomes. Over the past ~180 million years, the X and Y have become highly differentiated and now only recombine with each other within a s...

    Authors: Jennifer F. Hughes, Helen Skaletsky, Peter K. Nicholls, Alexis Drake, Tatyana Pyntikova, Ting-Jan Cho, Daniel W. Bellott and David C. Page
    Citation: BMC Biology 2022 20:133
  44. Generalist herbivores such as the two-spotted spider mite Tetranychus urticae thrive on a wide variety of plants and can rapidly adapt to novel hosts. What traits enable polyphagous herbivores to cope with the di...

    Authors: Christine Njiru, Wenxin Xue, Sander De Rouck, Juan M. Alba, Merijn R. Kant, Maksymilian Chruszcz, Bartel Vanholme, Wannes Dermauw, Nicky Wybouw and Thomas Van Leeuwen
    Citation: BMC Biology 2022 20:131
  45. Current understanding of the molecular basis of memory consolidation points to an important function of amyloid formation by neuronal-specific isoforms of the cytoplasmic polyadenylation element binding (CPEB)...

    Authors: D. Ramírez de Mingo, D. Pantoja-Uceda, R. Hervás, M. Carrión-Vázquez and D. V. Laurents
    Citation: BMC Biology 2022 20:129