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  1. The mitochondrial intermembrane space (IMS) is home to proteins fulfilling numerous essential cellular processes, particularly in metabolism and mitochondrial function. All IMS proteins are nuclear encoded and...

    Authors: Lena Maria Murschall, Anne Gerhards, Thomas MacVicar, Esra Peker, Lidwina Hasberg, Stephan Wawra, Thomas Langer and Jan Riemer

    Citation: BMC Biology 2020 18:96

    Content type: Research article

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  2. Avoiding danger and accessing environmental resources are two fundamental, yet conflicting, survival instincts across species. To maintain a balance between these instincts, animals must efficiently distinguis...

    Authors: Xing Yang, Qingqing Liu, Jinling Zhong, Ru Song, Lin Zhang and Liping Wang

    Citation: BMC Biology 2020 18:93

    Content type: Research article

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  3. Polydnaviruses (PDVs) are mutualistic endogenous viruses inoculated by some lineages of parasitoid wasps into their hosts, where they facilitate successful wasp development. PDVs include the ichnoviruses and b...

    Authors: Fabrice Legeai, Bernardo F. Santos, Stéphanie Robin, Anthony Bretaudeau, Rebecca B. Dikow, Claire Lemaitre, Véronique Jouan, Marc Ravallec, Jean-Michel Drezen, Denis Tagu, Frédéric Baudat, Gabor Gyapay, Xin Zhou, Shanlin Liu, Bruce A. Webb, Seán G. Brady…

    Citation: BMC Biology 2020 18:89

    Content type: Research article

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  4. Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied on ...

    Authors: Claude Rispe, Fabrice Legeai, Paul D. Nabity, Rosa Fernández, Arinder K. Arora, Patrice Baa-Puyoulet, Celeste R. Banfill, Leticia Bao, Miquel Barberà, Maryem Bouallègue, Anthony Bretaudeau, Jennifer A. Brisson, Federica Calevro, Pierre Capy, Olivier Catrice, Thomas Chertemps…

    Citation: BMC Biology 2020 18:90

    Content type: Research article

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  5. The binding of HIV-1 Envelope glycoproteins (Env) to host receptor CD4 exposes vulnerable conserved epitopes within the co-receptor binding site (CoRBS) which are required for the engagement of either CCR5 or ...

    Authors: William D. Tolbert, Rebekah Sherburn, Neelakshi Gohain, Shilei Ding, Robin Flinko, Chiara Orlandi, Krishanu Ray, Andrés Finzi, George K. Lewis and Marzena Pazgier

    Citation: BMC Biology 2020 18:91

    Content type: Research article

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  6. Understanding the mechanisms and timescales of plant pathogen outbreaks requires a detailed genome-scale analysis of their population history. The fungus Magnaporthe (Syn. Pyricularia) oryzae—the causal agent of ...

    Authors: Sergio M. Latorre, C. Sarai Reyes-Avila, Angus Malmgren, Joe Win, Sophien Kamoun and Hernán A. Burbano

    Citation: BMC Biology 2020 18:88

    Content type: Research article

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  7. The formation of supernumerary teeth is an excellent model for studying the molecular mechanisms that control stem/progenitor cell homeostasis needed to generate a renewable source of replacement cells and tis...

    Authors: Jingyi Wu, Ye Tian, Lu Han, Chao Liu, Tianyu Sun, Ling Li, Yanlei Yu, Bikash Lamichhane, Rena N. D’Souza, Sarah E. Millar, Robb Krumlauf, David M. Ornitz, Jian Q. Feng, Ophir Klein, Hu Zhao, Fuming Zhang…

    Citation: BMC Biology 2020 18:87

    Content type: Research article

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  8. Unlike most mammals, toothed whale (Odontoceti) skulls lack symmetry in the nasal and facial (nasofacial) region. This asymmetry is hypothesised to relate to echolocation, which may have evolved in the earlies...

    Authors: Ellen J. Coombs, Julien Clavel, Travis Park, Morgan Churchill and Anjali Goswami

    Citation: BMC Biology 2020 18:86

    Content type: Research article

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  9. Efforts to improve animal health, and understand genetic bases for production, may benefit from a comprehensive analysis of animal genomes and epigenomes. Although DNA methylation has been well studied in huma...

    Authors: Yang Zhou, Shuli Liu, Yan Hu, Lingzhao Fang, Yahui Gao, Han Xia, Steven G. Schroeder, Benjamin D. Rosen, Erin E. Connor, Cong-jun Li, Ransom L. Baldwin, John B. Cole, Curtis P. Van Tassell, Liguo Yang, Li Ma and George E. Liu

    Citation: BMC Biology 2020 18:85

    Content type: Research article

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  10. Heliconius butterflies are widely distributed across the Neotropics and have evolved a stunning array of wing color patterns that mediate Müllerian mimicry and mating behavior. Their rapid radiation has been stro...

    Authors: Darli Massardo, Nicholas W. VanKuren, Sumitha Nallu, Renato R. Ramos, Pedro G. Ribeiro, Karina L. Silva-Brandão, Marcelo M. Brandão, Marília B. Lion, André V. L. Freitas, Márcio Z. Cardoso and Marcus R. Kronforst

    Citation: BMC Biology 2020 18:84

    Content type: Research article

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  11. Experimental reproducibility in mouse models is impacted by both genetics and environment. The generation of reproducible data is critical for the biomedical enterprise and has become a major concern for the s...

    Authors: Rabindra K. Mandal, Joshua E. Denny, Morgan L. Waide, Qingsheng Li, Neal Bhutiani, Charles D. Anderson, Becca V. Baby, Venkatakrishna R. Jala, Nejat K. Egilmez and Nathan W. Schmidt

    Citation: BMC Biology 2020 18:83

    Content type: Research article

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  12. mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity ...

    Authors: Nathalie Bouquier, Enora Moutin, Lionel A. Tintignac, Amandine Reverbel, Elodie Jublanc, Michael Sinnreich, Yan Chastagnier, Julien Averous, Pierre Fafournoux, Chiara Verpelli, Tobias Boeckers, Gilles Carnac, Julie Perroy and Vincent Ollendorff

    Citation: BMC Biology 2020 18:81

    Content type: Research article

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  13. Lack of comprehensive functional annotations across a wide range of tissues and cell types severely hinders the biological interpretations of phenotypic variation, adaptive evolution, and domestication in live...

    Authors: Shuli Liu, Ying Yu, Shengli Zhang, John B. Cole, Albert Tenesa, Ting Wang, Tara G. McDaneld, Li Ma, George E. Liu and Lingzhao Fang

    Citation: BMC Biology 2020 18:80

    Content type: Research article

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  14. Luminescent reporter proteins are vital tools for visualizing cells and cellular activity. Among the current toolbox of bioluminescent systems, only bacterial luciferase has genetically defined luciferase and ...

    Authors: Michael Conway, Tingting Xu, Andrew Kirkpatrick, Steven Ripp, Gary Sayler and Dan Close

    Citation: BMC Biology 2020 18:79

    Content type: Methodology article

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  15. Sex chromosomes have evolved independently multiple times in eukaryotes and are therefore considered a prime example of convergent genome evolution. Sex chromosomes are known to emerge after recombination is h...

    Authors: Pedro Almeida, Estelle Proux-Wera, Allison Churcher, Lucile Soler, Jacques Dainat, Pascal Pucholt, Jessica Nordlund, Tom Martin, Ann-Christin Rönnberg-Wästljung, Björn Nystedt, Sofia Berlin and Judith E. Mank

    Citation: BMC Biology 2020 18:78

    Content type: Research article

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  16. Eukaryotic gene expression is controlled by a number of RNA-binding proteins (RBP), such as the proteins from the Puf (Pumilio and FBF) superfamily (PufSF). These proteins bind to RNA via multiple Puf repeat d...

    Authors: Vladimíra Najdrová, Courtney W. Stairs, Martina Vinopalová, Luboš Voleman and Pavel Doležal

    Citation: BMC Biology 2020 18:77

    Content type: Research article

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  17. Lymphocytes circulate between peripheral lymphoid tissues via blood and lymphatic systems, and chemokine-induced migration is important in trafficking lymphocytes to distant sites. The small GTPase Rap1 is imp...

    Authors: Sayaka Ishihara, Tsuyoshi Sato, Guangwei Du, Daniele Guardavaccaro, Akihiko Nakajima, Satoshi Sawai, Tohru Kataoka and Koko Katagiri

    Citation: BMC Biology 2020 18:75

    Content type: Research article

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  18. Copy number variations (CNVs) are an important type of structural variations in the genome that usually affect gene expression levels by gene dosage effect. Understanding CNVs as part of genome evolution may p...

    Authors: Fengli Zhao, Yuexing Wang, Jianshu Zheng, Yanling Wen, Minghao Qu, Shujing Kang, Shigang Wu, Xiaojuan Deng, Kai Hong, Sanfeng Li, Xing Qin, Zhichao Wu, Xiaobo Wang, Cheng Ai, Alun Li, Longjun Zeng…

    Citation: BMC Biology 2020 18:73

    Content type: Research article

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  19. Age-associated DNA methylation changes provide a promising biomarker for the aging process. While genome-wide DNA methylation profiles enable robust age-predictors by integration of many age-associated CG dinu...

    Authors: Yang Han, Julia Franzen, Thomas Stiehl, Michael Gobs, Chao-Chung Kuo, Miloš Nikolić, Jan Hapala, Barbara Elisabeth Koop, Klaus Strathmann, Stefanie Ritz-Timme and Wolfgang Wagner

    Citation: BMC Biology 2020 18:71

    Content type: Methodology article

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  20. Fleas (Insecta: Siphonaptera) are small flightless parasites of birds and mammals; their blood-feeding can transmit many serious pathogens (i.e., the etiological agents of bubonic plague, endemic and murine ty...

    Authors: Timothy P. Driscoll, Victoria I. Verhoeve, Joseph J. Gillespie, J. Spencer Johnston, Mark L. Guillotte, Kristen E. Rennoll-Bankert, M. Sayeedur Rahman, Darren Hagen, Christine G. Elsik, Kevin R. Macaluso and Abdu F. Azad

    Citation: BMC Biology 2020 18:70

    Content type: Research article

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  21. A unifying feature of the bacterial Candidate Phyla Radiation (CPR) is a limited and highly variable repertoire of biosynthetic capabilities. However, the distribution of metabolic traits across the CPR and th...

    Authors: Alexander L. Jaffe, Cindy J. Castelle, Paula B. Matheus Carnevali, Simonetta Gribaldo and Jillian F. Banfield

    Citation: BMC Biology 2020 18:69

    Content type: Research article

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  22. Plants have evolved a panoply of specialized metabolites that increase their environmental fitness. Two examples are caffeine, a purine psychotropic alkaloid, and crocins, a group of glycosylated apocarotenoid...

    Authors: Zhichao Xu, Xiangdong Pu, Ranran Gao, Olivia Costantina Demurtas, Steven J. Fleck, Michaela Richter, Chunnian He, Aijia Ji, Wei Sun, Jianqiang Kong, Kaizhi Hu, Fengming Ren, Jiejie Song, Zhe Wang, Ting Gao, Chao Xiong…

    Citation: BMC Biology 2020 18:63

    Content type: Research article

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  23. The homeobox genes Pdx and Cdx are widespread across the animal kingdom and part of the small ParaHox gene cluster. Gene expression patterns suggest ancient roles for Pdx and Cdx in patterning the through-gut of ...

    Authors: Yanhong Zhong, Carlos Herrera-Úbeda, Jordi Garcia-Fernàndez, Guang Li and Peter W. H. Holland

    Citation: BMC Biology 2020 18:68

    Content type: Research article

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  24. Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses...

    Authors: Joachim Kloehn, Rebecca D. Oppenheim, Ghizal Siddiqui, Pieter-Jan De Bock, Sunil Kumar Dogga, Yohann Coute, Mohamed-Ali Hakimi, Darren J. Creek and Dominique Soldati-Favre

    Citation: BMC Biology 2020 18:67

    Content type: Research article

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  25. Odor-driven behaviors such as feeding, mating, and predator avoidance are crucial for animal survival. The neural pathways processing these behaviors have been well characterized in a number of species, and in...

    Authors: Florence Kermen, Lea Darnet, Christoph Wiest, Fabrizio Palumbo, Jack Bechert, Ozge Uslu and Emre Yaksi

    Citation: BMC Biology 2020 18:66

    Content type: Research article

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  26. CRISPR-Cas systems, which provide adaptive immunity against foreign nucleic acids in prokaryotes, can serve as useful molecular tools for multiple applications in genome engineering. Diverse CRISPR-Cas systems...

    Authors: Donata Tuminauskaite, Danguole Norkunaite, Marija Fiodorovaite, Sarunas Tumas, Inga Songailiene, Giedre Tamulaitiene and Tomas Sinkunas

    Citation: BMC Biology 2020 18:65

    Content type: Research article

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  27. β7 integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin α4β7 binds MAdCAM-1, mediating rolling adhesion of lymphoc...

    Authors: Hailong Zhang, Yajuan Zheng, Youdong Pan, Changdong Lin, Shihui Wang, Zhanjun Yan, Ling Lu, Gaoxiang Ge, Jinsong Li, Yi Arial Zeng and Jianfeng Chen

    Citation: BMC Biology 2020 18:64

    Content type: Research article

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  28. Parkinson’s disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their f...

    Authors: Federico Baldini, Johannes Hertel, Estelle Sandt, Cyrille C. Thinnes, Lorieza Neuberger-Castillo, Lukas Pavelka, Fay Betsou, Rejko Krüger and Ines Thiele

    Citation: BMC Biology 2020 18:62

    Content type: Research article

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  29. Human-resident microbes can influence both health and disease. Investigating the microbiome using next-generation sequencing technology has revealed examples of mutualism and conflict between microbes and huma...

    Authors: Ryuichi Kumata, Jumpei Ito, Kenta Takahashi, Tadaki Suzuki and Kei Sato

    Citation: BMC Biology 2020 18:55

    Content type: Research article

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  30. Epithin/PRSS14, a type II transmembrane serine protease, is an emerging target of cancer therapy because of its critical roles in tumor progression and metastasis. In many circumstances, the protease, through ...

    Authors: Youngkyung Cho, Sang Bum Kim, Jiyoon Kim, An Vuong Quynh Pham, Min Ji Yoon, Jeong Hwan Park, Ki-Tae Hwang, Dongeun Park, Yongcheol Cho, Moon Gyo Kim and Chungho Kim

    Citation: BMC Biology 2020 18:60

    Content type: Research article

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  31. Network alterations underlying neurodegenerative diseases often precede symptoms and functional deficits. Thus, their early identification is central for improved prognosis. In Huntington’s disease (HD), the c...

    Authors: S. Fernández-García, J. G. Orlandi, G. A. García-Díaz Barriga, M. J. Rodríguez, M. Masana, J. Soriano and J. Alberch

    Citation: BMC Biology 2020 18:58

    Content type: Research article

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  32. Gene duplication events play an important role in the evolution and adaptation of organisms. Duplicated genes can arise through different mechanisms, including whole-genome duplications (WGDs). Recently, WGD w...

    Authors: Dick Roelofs, Arthur Zwaenepoel, Tom Sistermans, Joey Nap, Andries A. Kampfraath, Yves Van de Peer, Jacintha Ellers and Ken Kraaijeveld

    Citation: BMC Biology 2020 18:57

    Content type: Research article

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  33. Dinoflagellates are taxonomically diverse and ecologically important phytoplankton that are ubiquitously present in marine and freshwater environments. Mostly photosynthetic, dinoflagellates provide the basis ...

    Authors: Timothy G. Stephens, Raúl A. González-Pech, Yuanyuan Cheng, Amin R. Mohamed, David W. Burt, Debashish Bhattacharya, Mark A. Ragan and Cheong Xin Chan

    Citation: BMC Biology 2020 18:56

    Content type: Research article

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  34. The cline of human genetic diversity observable across Europe is recapitulated at a micro-geographic scale by variation within the Italian population. Besides resulting from extensive gene flow, this might be ...

    Authors: Marco Sazzini, Paolo Abondio, Stefania Sarno, Guido Alberto Gnecchi-Ruscone, Matteo Ragno, Cristina Giuliani, Sara De Fanti, Claudia Ojeda-Granados, Alessio Boattini, Julien Marquis, Armand Valsesia, Jerome Carayol, Frederic Raymond, Chiara Pirazzini, Elena Marasco, Alberto Ferrarini…

    Citation: BMC Biology 2020 18:51

    Content type: Research article

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  35. For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been ...

    Authors: John J. Wright, Justin G. Fedor, Judy Hirst and Maxie M. Roessler

    Citation: BMC Biology 2020 18:54

    Content type: Research article

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  36. Identifying causal variants and genes from human genetic studies of hematopoietic traits is important to enumerate basic regulatory mechanisms underlying these traits, and could ultimately augment translationa...

    Authors: Christopher Stephen Thom, Chintan D Jobaliya, Kimberly Lorenz, Jean Ann Maguire, Alyssa Gagne, Paul Gadue, Deborah L French and Benjamin Franklin Voight

    Citation: BMC Biology 2020 18:52

    Content type: Research article

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  37. The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, and con...

    Authors: Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari and John M. Marshall

    Citation: BMC Biology 2020 18:50

    Content type: Research article

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  38. Mitochondria are essential organelles partially regulated by their own genomes. The mitochondrial genome maintenance and inheritance differ from the nuclear genome, potentially uncoupling their evolutionary tr...

    Authors: Matteo De Chiara, Anne Friedrich, Benjamin Barré, Michael Breitenbach, Joseph Schacherer and Gianni Liti

    Citation: BMC Biology 2020 18:49

    Content type: Research article

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  39. Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largel...

    Authors: Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco…

    Citation: BMC Biology 2020 18:47

    Content type: Research article

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Announcement: COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.