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  1. Lymphangiogenesis, the formation of lymphatic vessels, is tightly linked to the development of the venous vasculature, both at the cellular and molecular levels. Here, we identify a novel role for Sorbs1, the ...

    Authors: Alexandra Veloso, Anouk Bleuart, Louise Conrard, Tanguy Orban, Jonathan Bruyr, Pauline Cabochette, Raoul F. V. Germano, Giel Schevenels, Alice Bernard, Egor Zindy, Sofie Demeyer, Benoit Vanhollebeke, Franck Dequiedt and Maud Martin
    Citation: BMC Biology 2024 22:51
  2. The formation and domestication of ornamental traits are influenced by various aspects, such as the recognition of esthetic values and cultural traditions. Camellia japonica is widely appreciated and domesticated...

    Authors: Zhikang Hu, Zhengqi Fan, Sijia Li, Minyan Wang, Mingchuan Huang, Xianjin Ma, Weixin Liu, Yupeng Wang, Yifan Yu, Yaxuan Li, Yingkun Sun, Xinlei Li, Jiyuan Li and Hengfu Yin
    Citation: BMC Biology 2024 22:50
  3. Resolving the phylogeny of rapidly radiating lineages presents a challenge when building the Tree of Life. An Old World avian family Prunellidae (Accentors) comprises twelve species that rapidly diversified at...

    Authors: Zhiyong Jiang, Wenqing Zang, Per G. P. Ericson, Gang Song, Shaoyuan Wu, Shaohong Feng, Sergei V. Drovetski, Gang Liu, Dezhi Zhang, Takema Saitoh, Per Alström, Scott V. Edwards, Fumin Lei and Yanhua Qu
    Citation: BMC Biology 2024 22:49
  4. Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell’s immediate environment: signal reception and transduction to/from the ciliated cell. De...

    Authors: Andrea Coschiera, Masahito Yoshihara, Gilbert Lauter, Sini Ezer, Mariangela Pucci, Haonan Li, Alan Kavšek, Christian G. Riedel, Juha Kere and Peter Swoboda
    Citation: BMC Biology 2024 22:48
  5. Crocodilians are one of the oldest extant vertebrate lineages, exhibiting a combination of evolutionary success and morphological resilience that has persisted throughout the history of life on Earth. This abi...

    Authors: Vanessa C. Sales-Oliveira, Rodrigo Zeni dos Santos, Caio Augusto Gomes Goes, Rodrigo Milan Calegari, Manuel A. Garrido-Ramos, Marie Altmanová, Tariq Ezaz, Thomas Liehr, Fabio Porto-Foresti, Ricardo Utsunomia and Marcelo B. Cioffi
    Citation: BMC Biology 2024 22:47
  6. Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones. The ass...

    Authors: Troy A. Kervin and Michael Overduin
    Citation: BMC Biology 2024 22:46
  7. Most disease resistance (R) genes in plants encode proteins that contain leucine-rich-repeat (LRR) and nucleotide-binding site (NBS) domains, which belong to the NBS-LRR family. The sequenced genomes of Fusarium ...

    Authors: Yunpeng Cao, Wanzhen Mo, Yanli Li, Yao Xiong, Han Wang, Yingjie Zhang, Mengfei Lin, Lin Zhang and Xiaoxu Li
    Citation: BMC Biology 2024 22:45
  8. Circular RNAs (circRNAs) can regulate microRNA activity and are related to various diseases, such as cancer. Functional research on circRNAs is the focus of scientific research. Accurate identification of circ...

    Authors: Mengting Niu, Chunyu Wang, Yaojia Chen, Quan Zou, Ren Qi and Lei Xu
    Citation: BMC Biology 2024 22:44
  9. High tumor mutational burden (TMB) was reported to predict the efficacy of immune checkpoint inhibitors (ICIs). Pembrolizumab, an anti-PD-1, received FDA-approval for the treatment of unresectable/metastatic t...

    Authors: Célia Dupain, Tom Gutman, Elodie Girard, Choumouss Kamoun, Grégoire Marret, Zahra Castel-Ajgal, Marie-Paule Sablin, Cindy Neuzillet, Edith Borcoman, Ségolène Hescot, Céline Callens, Olfa Trabelsi-Grati, Samia Melaabi, Roseline Vibert, Samantha Antonio, Coralie Franck…
    Citation: BMC Biology 2024 22:43
  10. The adaptive mechanisms of agricultural pests are the key to understanding the evolution of the pests and to developing new control strategies. However, there are few studies on the genetic basis of adaptation...

    Authors: Ping Wang, Minghui Jin, Chao Wu, Yan Peng, Yanjin He, Hanyue Wang and Yutao Xiao
    Citation: BMC Biology 2024 22:42
  11. Prior to soil formation, phosphate liberated by rock weathering is often sequestered into highly insoluble lanthanide phosphate minerals. Dissolution of these minerals releases phosphate and lanthanides to the...

    Authors: Marcos Y. Voutsinos, Jacob A. West-Roberts, Rohan Sachdeva, John W. Moreau and Jillian F. Banfield
    Citation: BMC Biology 2024 22:41
  12. Threshold-dependent gene drives (TDGDs) could be used to spread desirable traits through a population, and are likely to be less invasive and easier to control than threshold-independent gene drives. Engineere...

    Authors: Anna Janzen, Ratnasri Pothula, Adam Sychla, Nathan R. Feltman and Michael J. Smanski
    Citation: BMC Biology 2024 22:40
  13. Surrogate production by germline stem cell transplantation is a powerful method to produce donor-derived gametes via a host, a practice known as surrogacy. The gametes produced by surrogates are often analysed...

    Authors: Rigolin Nayak, Roman Franěk, Audrey Laurent and Martin Pšenička
    Citation: BMC Biology 2024 22:39
  14. Plants have complex and dynamic immune systems that have evolved to resist pathogens. Humans have worked to enhance these defenses in crops through breeding. However, many crops harbor only a fraction of the g...

    Authors: Noah P. Winters, Eric K. Wafula, Benjamin J. Knollenberg, Tuomas Hämälä, Prakash R. Timilsena, Melanie Perryman, Dapeng Zhang, Lena L. Sheaffer, Craig A. Praul, Paula E. Ralph, Sarah Prewitt, Mariela E. Leandro-Muñoz, Diego A. Delgadillo-Duran, Naomi S. Altman, Peter Tiffin, Siela N. Maximova…
    Citation: BMC Biology 2024 22:38
  15. In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection...

    Authors: Alfa Dhakal, Chinnu Salim, Mary Skelly, Yarden Amichan, Ayelet T. Lamm and Heather A. Hundley
    Citation: BMC Biology 2024 22:37
  16. The identification of cell type-specific genes and their modification under different conditions is central to our understanding of human health and disease. The stomach, a hollow organ in the upper gastrointe...

    Authors: S. Öling, E. Struck, M. Noreen-Thorsen, M. Zwahlen, K. von Feilitzen, J. Odeberg, F. Pontén, C. Lindskog, M. Uhlén, P. Dusart and L. M. Butler
    Citation: BMC Biology 2024 22:36
  17. Social behavior and social organization have major influences on individual health and fitness. Yet, biomedical research focuses on studying a few genotypes under impoverished social conditions. Understanding ...

    Authors: Caleb C. Vogt, Matthew N. Zipple, Daniel D. Sprockett, Caitlin H. Miller, Summer X. Hardy, Matthew K. Arthur, Adam M. Greenstein, Melanie S. Colvin, Lucie M. Michel, Andrew H. Moeller and Michael J. Sheehan
    Citation: BMC Biology 2024 22:35
  18. Viviparity—live birth—is a complex and innovative mode of reproduction that has evolved repeatedly across the vertebrate Tree of Life. Viviparous species exhibit remarkable levels of reproductive diversity, bo...

    Authors: Rhiannon V. Eastment, Bob B. M. Wong and Matthew D. McGee
    Citation: BMC Biology 2024 22:34
  19. Ribosomal protein SA (RPSA) of human brain microvascular endothelial cells (HBMECs) can transfer from the cytosol to the cell surface and act as a receptor for some pathogens, including Streptococcus suis serotyp...

    Authors: Hexiang Jiang, Yi Sun, Fengyang Li, Xibing Yu, Siyu Lei, Sulan Du, Tong Wu, Xuan Jiang, Junhui Zhu, Jun Wang, Yalu Ji, Na Li, Xin Feng, Jingmin Gu, Wenyu Han, Lei Zeng…
    Citation: BMC Biology 2024 22:33
  20. The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A virus (IAV), harbors almost all subtypes of IAVs and resists to many IAVs which cause extreme virulence in chicken and human. ...

    Authors: Jiaxiang Hu, Linfei Song, Mengfei Ning, Xinyu Niu, Mengying Han, Chuze Gao, Xingwei Feng, Han Cai, Te Li, Fangtao Li, Huifang Li, Daoqing Gong, Weitao Song, Long Liu, Juan Pu, Jinhua Liu…
    Citation: BMC Biology 2024 22:31
  21. Despite the increasing number of epigenomic studies in plants, little is known about the forces that shape the methylome in long-lived woody perennials. The Lombardy poplar offers an ideal opportunity to inves...

    Authors: An Vanden Broeck, Tim Meese, Pieter Verschelde, Karen Cox, Berthold Heinze, Dieter Deforce, Ellen De Meester and Filip Van Nieuwerburgh
    Citation: BMC Biology 2024 22:30
  22. Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity. For example, the human Ether-a-go-go Related Gene (hERG) cha...

    Authors: Zhipei Liu, Feng Wang, Hui Yuan, Fuyun Tian, Chuanyan Yang, Fei Hu, Yiyao Liu, Meiqin Tang, Meixuan Ping, Chunlan Kang, Ting Luo, Guimei Yang, Mei Hu, Zhaobing Gao and Ping Li
    Citation: BMC Biology 2024 22:29
  23. The human brain can rapidly represent sets of similar stimuli by their ensemble summary statistics, like the average orientation or size. Classic models assume that ensemble statistics are computed by integrat...

    Authors: Natalia A. Tiurina, Yuri A. Markov, David Whitney and David Pascucci
    Citation: BMC Biology 2024 22:28
  24. Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) cause a wide variety of bacterial infections and coinfections, showing a complex interaction that involves the production of different metabolites and me...

    Authors: E. C. Solar Venero, M. B. Galeano, A. Luqman, M. M. Ricardi, F. Serral, D. Fernandez Do Porto, S. A. Robaldi, B. A. Z. Ashari, T. H. Munif, D. E. Egoburo, S. Nemirovsky, J. Escalante, B. Nishimura, M. S. Ramirez, F. Götz and P. M. Tribelli
    Citation: BMC Biology 2024 22:27
  25. The ability of recombinant adeno-associated virus to transduce preimplantation mouse embryos has led to the use of this delivery method for the production of genetically altered knock-in mice via CRISPR-Cas9. ...

    Authors: Graham Duddy, Katherine Courtis, Juliette Horwood, Jessica Olsen, Helen Horsler, Tina Hodgson, Sunita Varsani-Brown, Abdullah Abdullah, Laura Denti, Hollie Lane, Fabio Delaqua, Julia Janzen, Molly Strom, Ian Rosewell, Katharine Crawley and Benjamin Davies
    Citation: BMC Biology 2024 22:26
  26. Glioblastoma (GBM) is more difficult to treat than other intractable adult tumors. The main reason that GBM is so difficult to treat is that it is highly infiltrative. Migrasomes are newly discovered membrane ...

    Authors: Seon Yong Lee, Sang-Hun Choi, Yoonji Kim, Hee-Sung Ahn, Young-Gyu Ko, Kyunggon Kim, Sung Wook Chi and Hyunggee Kim
    Citation: BMC Biology 2024 22:23
  27. Fungal plant pathogens have dynamic genomes that allow them to rapidly adapt to adverse conditions and overcome host resistance. One way by which this dynamic genome plasticity is expressed is through effector...

    Authors: Alex Z. Zaccaron and Ioannis Stergiopoulos
    Citation: BMC Biology 2024 22:25
  28. Circular RNAs (circRNAs) have been confirmed to play a vital role in the occurrence and development of diseases. Exploring the relationship between circRNAs and diseases is of far-reaching significance for stu...

    Authors: Mengting Niu, Chunyu Wang, Zhanguo Zhang and Quan Zou
    Citation: BMC Biology 2024 22:24
  29. Hematophagous mosquitoes transmit many pathogens that cause human diseases. Pathogen acquisition and transmission occur when female mosquitoes blood feed to acquire nutrients for reproduction. The midgut epith...

    Authors: M. L. Taracena-Agarwal, B. Hixson, S. Nandakumar, A. P. Girard-Mejia, R. Y. Chen, L. Huot, N. Padilla and N. Buchon
    Citation: BMC Biology 2024 22:22
  30. The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of the full landscape of their evolutionary history and complex trait architecture. South...

    Authors: Guanglin He, Peixin Wang, Jing Chen, Yan Liu, Yuntao Sun, Rong Hu, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Junbao Yang, Zhiyong Wang, Libing Yun, Liping Hu, Jiangwei Yan, Shengjie Nie, Lanhai Wei…
    Citation: BMC Biology 2024 22:18
  31. Due to interindividual variation in the cellular composition of the human cortex, it is essential that covariates that capture these differences are included in epigenome-wide association studies using bulk ti...

    Authors: Eilis Hannon, Emma L. Dempster, Jonathan P. Davies, Barry Chioza, Georgina E. T. Blake, Joe Burrage, Stefania Policicchio, Alice Franklin, Emma M. Walker, Rosemary A. Bamford, Leonard C. Schalkwyk and Jonathan Mill
    Citation: BMC Biology 2024 22:17
  32. Understanding genome organization and evolution is important for species involved in transmission of human diseases, such as mosquitoes. Anophelinae and Culicinae subfamilies of mosquitoes show striking differ...

    Authors: Sergei S. Ryazansky, Chujia Chen, Mark Potters, Anastasia N. Naumenko, Varvara Lukyanchikova, Reem A. Masri, Ilya I. Brusentsov, Dmitriy A. Karagodin, Andrey A. Yurchenko, Vitor L. dos Anjos, Yuki Haba, Noah H. Rose, Jinna Hoffman, Rong Guo, Theresa Menna, Melissa Kelley…
    Citation: BMC Biology 2024 22:16
  33. Mosquito borne viruses, such as dengue, Zika, yellow fever and Chikungunya, cause millions of infections every year. These viruses are mostly transmitted by two urban-adapted mosquito species, Aedes aegypti and A...

    Authors: Carlos F. Estevez-Castro, Murillo F. Rodrigues, Antinéa Babarit, Flávia V. Ferreira, Elisa G. de Andrade, Eric Marois, Rodrigo Cogni, Eric R. G. R. Aguiar, João T. Marques and Roenick P. Olmo
    Citation: BMC Biology 2024 22:14
  34. Single-nucleotide polymorphisms (SNPs) are the most widely used form of molecular genetic variation studies. As reference genomes and resequencing data sets expand exponentially, tools must be in place to call...

    Authors: Yong Zhou, Nagarajan Kathiresan, Zhichao Yu, Luis F. Rivera, Yujian Yang, Manjula Thimma, Keerthana Manickam, Dmytro Chebotarov, Ramil Mauleon, Kapeel Chougule, Sharon Wei, Tingting Gao, Carl D. Green, Andrea Zuccolo, Weibo Xie, Doreen Ware…
    Citation: BMC Biology 2024 22:13
  35. Many viruses enter host cells by hijacking endosomal trafficking. CapZ, a canonical actin capping protein, participates in endosomal trafficking, yet its precise role in endocytosis and virus infection remains...

    Authors: Huazhang Zhu, Dawei Wang, Zuodong Ye, Lihong Huang, Wenjie Wei, Kui Ming Chan, Rongxin Zhang, Liang Zhang and Jianbo Yue
    Citation: BMC Biology 2024 22:12
  36. The remarkable resistance to ionizing radiation found in anhydrobiotic organisms, such as some bacteria, tardigrades, and bdelloid rotifers has been hypothesized to be incidental to their desiccation resistanc...

    Authors: Victoria C. Moris, Lucie Bruneau, Jérémy Berthe, Anne-Catherine Heuskin, Sébastien Penninckx, Sylvia Ritter, Uli Weber, Marco Durante, Etienne G. J. Danchin, Boris Hespeels and Karine Van Doninck
    Citation: BMC Biology 2024 22:11
  37. Dimorphism, the ability to switch between a ‘yeast-like’ and a hyphal growth form, is an important feature of certain fungi, including important plant and human pathogens. The switch to hyphal growth is often ...

    Authors: Andrea Kovács-Simon and Helen N. Fones
    Citation: BMC Biology 2024 22:10
  38. How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processe...

    Authors: Jessica A. Goodheart, Robin A. Rio, Neville F. Taraporevala, Rose A. Fiorenza, Seth R. Barnes, Kevin Morrill, Mark Allan C. Jacob, Carl Whitesel, Park Masterson, Grant O. Batzel, Hereroa T. Johnston, M. Desmond Ramirez, Paul S. Katz and Deirdre C. Lyons
    Citation: BMC Biology 2024 22:9
  39. Mosquitoes transmit many infectious diseases that affect human health. The fungus Beauveria bassiana is a biological pesticide that is pathogenic to mosquitoes but harmless to the environment.

    Authors: Tengfei Lu, Yannan Ji, Mengmeng Chang, Xiaoming Zhang, Yanhong Wang and Zhen Zou
    Citation: BMC Biology 2024 22:7
  40. Precise gene targeting (GT) is a powerful tool for heritable precision genome engineering, enabling knock-in or replacement of the endogenous sequence via homologous recombination. We recently established a CR...

    Authors: Jing Li, Dali Kong, Yongping Ke, Wenjie Zeng and Daisuke Miki
    Citation: BMC Biology 2024 22:6
  41. SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets agains...

    Authors: Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer and Katrin Paeschke
    Citation: BMC Biology 2024 22:5
  42. The common carp (Cyprinus carpio) might best represent the domesticated allopolyploid animals. Although subgenome divergence which is well-known to be a key to allopolyploid domestication has been comprehensively...

    Authors: Min Wang, Xinxin Li, Chongnv Wang, Ming Zou, Jing Yang, Xiang-dong Li and Baocheng Guo
    Citation: BMC Biology 2024 22:4
  43. Cell senescence is a sign of aging and plays a significant role in the pathogenesis of age-related disorders. For cell therapy, senescence may compromise the quality and efficacy of cells, posing potential saf...

    Authors: Liangge He, Mingzhu Li, Xinglie Wang, Xiaoyan Wu, Guanghui Yue, Tianfu Wang, Yan Zhou, Baiying Lei and Guangqian Zhou
    Citation: BMC Biology 2024 22:1
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