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  1. The intermediate filament protein vimentin is widely recognized as a molecular marker of epithelial-to-mesenchymal transition. Although vimentin expression is strongly associated with cancer metastatic potenti...

    Authors: Jiyoung Jang, Hyun Jung Park, Wonyoung Seong, Jiyoon Kim and Chungho Kim
    Citation: BMC Biology 2024 22:139
  2. The vast majority of the food we eat comes from land-based agriculture, but recent technological advances in agriculture and food technology offer the prospect of producing food using substantially less or eve...

    Authors: H. Charles J. Godfray, Joseph Poore and Hannah Ritchie
    Citation: BMC Biology 2024 22:138
  3. Coevolution between modern aphids and their primary obligate, bacterial endosymbiont, Buchnera aphidicola, has been previously reported at different classification levels based on molecular phylogenetic analyses....

    Authors: Yukang Liang, Rebecca B. Dikow, Xu Su, Jun Wen and Zhumei Ren
    Citation: BMC Biology 2024 22:137
  4. Most tail-anchored (TA) membrane proteins are delivered to the endoplasmic reticulum through a conserved posttranslational pathway. Although core mechanisms underlying the targeting and insertion of TA protein...

    Authors: Chi-Chih Chen, Yu-Ru Huang, Yuen Ting Chan, Hung-Yun Lin, Han-Jia Lin, Chwan-Deng Hsiao, Tzu-Ping Ko, Tai-Wen Lin, Ya-Hsuan Lan, Hsuan-Ya Lin and Hsin-Yang Chang
    Citation: BMC Biology 2024 22:136
  5. Evolution of novelty is a central theme in evolutionary biology, yet studying the origins of traits with an apparently discontinuous origin remains a major challenge. Venom systems are a well-suited model for ...

    Authors: Vanessa Schendel, Carsten H. G. Müller, Matthes Kenning, Michael Maxwell, Ronald A. Jenner, Eivind A. B. Undheim and Andy Sombke
    Citation: BMC Biology 2024 22:135
  6. Inherited retinal dystrophies (IRDs) are a group of debilitating visual disorders characterized by the progressive degeneration of photoreceptors, which ultimately lead to blindness. Among the causes of this c...

    Authors: Kaifang Wang, Huijuan Xu, Rong Zou, Guangqun Zeng, Ye Yuan, Xianjun Zhu, Xiaohui Zhao, Jie Li and Lin Zhang
    Citation: BMC Biology 2024 22:134
  7. Hepatocellular carcinoma (HCC) is a prevalent malignancy with a pressing need for improved therapeutic response and prognosis prediction. This study delves into a novel predictive model related to ferroptosis,...

    Authors: Qiong Zhou, Chunyu Tao, Yuli Ge, Jiakai Yuan, Fan Pan, Xinrong Lin and Rui Wang
    Citation: BMC Biology 2024 22:133
  8. ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is thought to play a significant role both in tumor suppression and tumor initiation, which is highly dependent upon context. Previous studies hav...

    Authors: Tianyu Zhu, Qian Li, Zhe Zhang, Jiahao Shi, Yongyun Li, Feng Zhang, Lingjie Li, Xin Song, Jianfeng Shen and Renbing Jia
    Citation: BMC Biology 2024 22:132
  9. Fine characterization of gene expression patterns is crucial to understand many aspects of embryonic development. The chicken embryo is a well-established and valuable animal model for developmental biology. T...

    Authors: Maëlys André, Sarah Dinvaut, Valérie Castellani and Julien Falk
    Citation: BMC Biology 2024 22:131
  10. Hydrogenosomes are a specific type of mitochondria that have adapted for life under anaerobiosis. Limited availability of oxygen has resulted in the loss of the membrane-associated respiratory chain, and conse...

    Authors: Abhijith Makki, Sami Kereïche, Tien Le, Jitka Kučerová, Petr Rada, Vojtěch Žárský, Ivan Hrdý and Jan Tachezy
    Citation: BMC Biology 2024 22:130
  11. The female locust is equipped with unique digging tools, namely two pairs of valves—a dorsal and a ventral—utilized for excavating an underground hole in which she lays her eggs. This apparatus ensures that th...

    Authors: Shmuel Gershon, Benny Bar-On, Shai Sonnenreich, Amir Ayali and Bat-El Pinchasik
    Citation: BMC Biology 2024 22:129
  12. In yeasts belonging to the subphylum Saccharomycotina, genes encoding components of the main metabolic pathways, like alcoholic fermentation, are usually conserved. However, in fructophilic species belonging t...

    Authors: Ana Pontes, Francisca Paraíso, Margarida Silva, Catarina Lagoas, Andreia Aires, Patrícia H. Brito, Carlos A. Rosa, Marc-André Lachance, José Paulo Sampaio, Carla Gonçalves and Paula Gonçalves
    Citation: BMC Biology 2024 22:128
  13. Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling adapt...

    Authors: Kim Moorwood, Florentia M. Smith, Alastair S. Garfield and Andrew Ward
    Citation: BMC Biology 2024 22:127
  14. A promoter is a specific sequence in DNA that has transcriptional regulatory functions, playing a role in initiating gene expression. Identifying promoters and their strengths can provide valuable information ...

    Authors: Yazi Li, Xiaoman Wei, Qinglin Yang, An Xiong, Xingfeng Li, Quan Zou, Feifei Cui and Zilong Zhang
    Citation: BMC Biology 2024 22:126
  15. Bacterial epigenetics is a rapidly expanding research field. DNA methylation by diverse bacterial methyltransferases (MTases) contributes to genomic integrity and replication, and many recent studies extended ...

    Authors: Lubna Patel, Florent Ailloud, Sebastian Suerbaum and Christine Josenhans
    Citation: BMC Biology 2024 22:125
  16. Regulation of transcription by DNA methylation in 5’-CpG-3’ context is a widespread mechanism allowing differential expression of genetically identical cells to persist throughout development. Consequently, di...

    Authors: Jesper Boman, Anna Qvarnström and Carina F. Mugal
    Citation: BMC Biology 2024 22:124
  17. Various animal taxa have specialized to living with social hosts. Depending on their level of specialization, these symbiotic animals are characterized by distinct behavioural, chemical, and morphological trai...

    Authors: Thomas Parmentier, Rafael Molero-Baltanás, Catalina Valdivia, Miquel Gaju-Ricart, Pascal Boeckx, Piotr Łukasik and Nicky Wybouw
    Citation: BMC Biology 2024 22:123
  18. The innate immune system serves as the first line of host defense. Transforming growth factor-β–activated kinase 1 (TAK1) is a key regulator of innate immunity, cell survival, and cellular homeostasis. Because...

    Authors: Ratnakar R. Bynigeri, R. K. Subbarao Malireddi, Raghvendra Mall, Jon P. Connelly, Shondra M. Pruett-Miller and Thirumala-Devi Kanneganti
    Citation: BMC Biology 2024 22:122
  19. Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of th...

    Authors: Ellen T. Koch, Judy Cheng, Daniel Ramandi, Marja D. Sepers, Alex Hsu, Tony Fong, Timothy H. Murphy, Eric Yttri and Lynn A. Raymond
    Citation: BMC Biology 2024 22:121
  20. Threat and individual differences in threat-processing bias perception of stimuli in the environment. Yet, their effect on perception of one’s own (body-based) self-motion in space is unknown. Here, we tested ...

    Authors: Shira Hacohen-Brown, Eva Gilboa-Schechtman and Adam Zaidel
    Citation: BMC Biology 2024 22:120
  21. Many efforts have been made to improve the precision of Cas9-mediated gene editing through increasing knock-in efficiency and decreasing byproducts, which proved to be challenging.

    Authors: Hui Shi, Lei Li, Shuangshuang Mu, Shixue Gou, Xiaoyi Liu, Fangbing Chen, Menglong Chen, Qin Jin, Liangxue Lai and Kepin Wang
    Citation: BMC Biology 2024 22:119
  22. The animal sperm shows high diversity in morphology, components, and motility. In the lepidopteran model insect, the silkworm Bombyx mori, two types of sperm, including nucleate fertile eupyrene sperm and anuclea...

    Authors: Zhongjie Zhang, Xiaojing Liu, Bo Hu, Kai Chen, Ye Yu, Chenxin Sun, Dalin Zhu, Hua Bai, Subba Reddy Palli and Anjiang Tan
    Citation: BMC Biology 2024 22:118
  23. Verticillium wilt, caused by the fungus Verticillium dahliae, is a soil-borne vascular fungal disease, which has caused great losses to cotton yield and quality worldwide. The strain KRS010 was isolated from the ...

    Authors: Yujia Shan, Dan Wang, Fu-Hua Zhao, Jian Song, He Zhu, Yue Li, Xiao-Jun Zhang, Xiao-Feng Dai, Dongfei Han and Jie-Yin Chen
    Citation: BMC Biology 2024 22:116
  24. Thromboinflammation is caused by mutual activation of platelets and neutrophils. The site of thromboinflammation is determined by chemoattracting agents release by endothelium, immune cells, and platelets. Imp...

    Authors: Julia-Jessica D. Korobkin, Ekaterina A. Deordieva, Ivan P. Tesakov, Ekaterina-Iva A. Adamanskaya, Anna E. Boldova, Antonina A. Boldyreva, Sofia V. Galkina, Daria P. Lazutova, Alexey A. Martyanov, Vitaly A. Pustovalov, Galina A. Novichkova, Anna Shcherbina, Mikhail A. Panteleev and Anastasia N. Sveshnikova
    Citation: BMC Biology 2024 22:115
  25. Cotton is a major world cash crop and an important source of natural fiber, oil, and protein. Drought stress is becoming a restrictive factor affecting cotton production. To facilitate the development of droug...

    Authors: Boyang Zhang, Yuexuan Long, Liuling Pei, Xianhui Huang, Baoqi Li, Bei Han, Mengmeng Zhang, Keith Lindsey, Xianlong Zhang, Maojun Wang and Xiyan Yang
    Citation: BMC Biology 2024 22:114
  26. Protein posttranslational modifications (PTMs) are fast and early responses to environmental changes, including pathogen infection. Jujube witches’ broom (JWB) is a phytoplasma disease causing great economic l...

    Authors: Liman Zhang, Huibin Wang, Chaoling Xue, Yin Liu, Yao Zhang, Zhiguo Liu, Xiangrui Meng, Mengjun Liu and Jin Zhao
    Citation: BMC Biology 2024 22:113
  27. Fungi and ants belong to the most important organisms in terrestrial ecosystems on Earth. In nutrient-poor niches of tropical rainforests, they have developed steady ecological relationships as a successful su...

    Authors: Veronica Barrajon-Santos, Maximilian Nepel, Bela Hausmann, Hermann Voglmayr, Dagmar Woebken and Veronika E. Mayer
    Citation: BMC Biology 2024 22:112
  28. Juvenile hormones (JH) play crucial role in regulating development and reproduction in insects. The most common form of JH is JH III, derived from MF through epoxidation by CYP15 enzymes. However, in the highe...

    Authors: Qiangqiang Jia, Liu Yang, Jiamin Wen, Suning Liu, Di Wen, Wei Luo, Weihua Wang, Subba Reddy Palli and Li Sheng
    Citation: BMC Biology 2024 22:111
  29. Plants differ more than threefold in seed oil contents (SOCs). Soybean (Glycine max), cotton (Gossypium hirsutum), rapeseed (Brassica napus), and sesame (Sesamum indicum) are four important oil crops with markedl...

    Authors: Jinwen Chen, Yan Hu, Ting Zhao, Chujun Huang, Jiani Chen, Lu He, Fan Dai, Shuqi Chen, Luyao Wang, Shangkun Jin and Tianzhen Zhang
    Citation: BMC Biology 2024 22:110
  30. Social insects vary considerably in their social organization both between and within species. In the California harvester ant, Pogonomyrmex californicus (Buckley 1867), colonies are commonly founded and headed b...

    Authors: Mohammed Errbii, Ulrich R. Ernst, Aparna Lajmi, Eyal Privman, Jürgen Gadau and Lukas Schrader
    Citation: BMC Biology 2024 22:109
  31. Populations of the plant pathogenic fungus Verticillium dahliae display a complex and rich genetic diversity, yet the existence of sexual reproduction in the fungus remains contested. As pivotal genes, MAT genes ...

    Authors: Ya-Duo Zhang, Xiao-Bin Ji, Juan Zong, Xiao-Feng Dai, Steven J. Klosterman, Krishna V. Subbarao, Dan-Dan Zhang and Jie-Yin Chen
    Citation: BMC Biology 2024 22:108
  32. Histone H3K4 tri-methylation (H3K4me3) catalyzed by Set1/COMPASS, is a prominent epigenetic mark found in promoter-proximal regions of actively transcribed genes. H3K4me3 relies on prior monoubiquitination at ...

    Authors: Junsoo Oh, Shinae Park, Jueun Kim, Soojin Yeom, Ji Min Lee, Eun-Jin Lee, Yong-Joon Cho and Jung-Shin Lee
    Citation: BMC Biology 2024 22:105
  33. Gonadotropin precisely controls mammalian reproductive activities. Systematic analysis of the mechanisms by which epigenetic modifications regulate the synthesis and secretion of gonadotropin can be useful for...

    Authors: Hao-Qi Wang, Yi-Ran Ma, Yu-Xin Zhang, Fan-Hao Wei, Yi Zheng, Zhong-Hao Ji, Hai-Xiang Guo, Tian Wang, Jia-Bao Zhang and Bao Yuan
    Citation: BMC Biology 2024 22:104
  34. Ascetosporea (Endomyxa, Rhizaria) is a group of unicellular parasites infecting aquatic invertebrates. They are increasingly being recognized as widespread and important in marine environments, causing large a...

    Authors: Markus Hiltunen Thorén, Ioana Onuț-Brännström, Anders Alfjorden, Hana Pecková, Fiona Swords, Chantelle Hooper, Astrid S. Holzer, David Bass and Fabien Burki
    Citation: BMC Biology 2024 22:103
  35. Sex-limited chromosomes Y and W share some characteristics, including the degeneration of protein-coding genes, enrichment of repetitive elements, and heterochromatin. However, although many studies have sugge...

    Authors: Wenting Dai, Judith E. Mank and Liping Ban
    Citation: BMC Biology 2024 22:102
  36. CRISPR-Cas9 genome editing often induces unintended, large genomic rearrangements, posing potential safety risks. However, there are no methods for mitigating these risks.

    Authors: Baolei Yuan, Chongwei Bi, Yeteng Tian, Jincheng Wang, Yiqing Jin, Khaled Alsayegh, Muhammad Tehseen, Gang Yi, Xuan Zhou, Yanjiao Shao, Fernanda Vargas Romero, Wolfgang Fischle, Juan Carlos Izpisua Belmonte, Samir Hamdan, Yanyi Huang and Mo Li
    Citation: BMC Biology 2024 22:101
  37. Plant pathogens secrete effector proteins into host cells to suppress immune responses and manipulate fundamental cellular processes. One of these processes is autophagy, an essential recycling mechanism in eu...

    Authors: Serena Testi, Marie-Line Kuhn, Valérie Allasia, Pascaline Auroy, Fantao Kong, Gilles Peltier, Sophie Pagnotta, Julie Cazareth, Harald Keller and Franck Panabières
    Citation: BMC Biology 2024 22:100
  38. The ability of animals to regenerate damaged tissue is a complex process that involves various cellular mechanisms. As animals age, they lose their regenerative abilities, making it essential to understand the...

    Authors: Sara Ahmed-de-Prado, Carlos Estella and Antonio Baonza
    Citation: BMC Biology 2024 22:98
  39. The early Cambrian arthropod clade Megacheira, also referred to as great appendage arthropods, comprised a group of diminutive and elongated predators during the early Palaeozoic era, around 518 million years ...

    Authors: Michel Schmidt, Xianguang Hou, Huijuan Mai, Guixian Zhou, Roland R. Melzer, Xilin Zhang and Yu Liu
    Citation: BMC Biology 2024 22:96
  40. The medial prefrontal cortex (mPFC) is involved in complex functions containing multiple types of neurons in distinct subregions with preferential roles. The pyramidal neurons had wide-range projections to cor...

    Authors: Ayizuohere Tudi, Mei Yao, Feifang Tang, Jiandong Zhou, Anan Li, Hui Gong, Tao Jiang and Xiangning Li
    Citation: BMC Biology 2024 22:95
  41. Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by hypomorphic loss of function in the survival motor neuron (SMN) protein. SMA presents across a broad spectrum of disease severity....

    Authors: Eric L. Garcia, Rebecca E. Steiner, Amanda C. Raimer, Laura E. Herring, A. Gregory Matera and Ashlyn M. Spring
    Citation: BMC Biology 2024 22:94
  42. The human upper respiratory tract (URT) microbiome, like the gut microbiome, varies across individuals and between health and disease states. However, study-to-study heterogeneity in reported case–control resu...

    Authors: Nick Quinn-Bohmann, Jose A. Freixas-Coutin, Jin Seo, Ruth Simmons, Christian Diener and Sean M. Gibbons
    Citation: BMC Biology 2024 22:93
  43. Transposable elements (TEs) have a profound influence on the trajectory of plant evolution, driving genome expansion and catalyzing phenotypic diversification. The pangenome, a comprehensive genetic pool encom...

    Authors: Xin He, Zhengyang Qi, Zhenping Liu, Xing Chang, Xianlong Zhang, Jianying Li and Maojun Wang
    Citation: BMC Biology 2024 22:92
  44. Elephant seals exhibit extreme hypoxemic tolerance derived from repetitive hypoxia/reoxygenation episodes they experience during diving bouts. Real-time assessment of the molecular changes underlying protectio...

    Authors: Kaitlin N. Allen, Julia María Torres-Velarde, Juan Manuel Vazquez, Diana D. Moreno-Santillán, Peter H. Sudmant and José Pablo Vázquez-Medina
    Citation: BMC Biology 2024 22:91
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