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  1. Research article

    Role of PCNA and RFC in promoting Mus81-complex activity

    Proper DNA replication is essential for faithful transmission of the genome. However, replication stress has serious impact on the integrity of the cell, leading to stalling or collapse of replication forks, a...

    Alexandra Sisakova, Veronika Altmannova, Marek Sebesta and Lumir Krejci

    BMC Biology 2017 15:90

    Published on: 2 October 2017

  2. Review

    Human evolution: the non-coding revolution

    What made us human? Gene expression changes clearly played a significant part in human evolution, but pinpointing the causal regulatory mutations is hard. Comparative genomics enabled the identification of hum...

    Lucía F. Franchini and Katherine S. Pollard

    BMC Biology 2017 15:89

    Published on: 2 October 2017

  3. Research article

    A Drosophila female pheromone elicits species-specific long-range attraction via an olfactory channel with dual specificity for sex and food

    Mate finding and recognition in animals evolves during niche adaptation and involves social signals and habitat cues. Drosophila melanogaster and related species are known to be attracted to fermenting fruit for ...

    Sebastien Lebreton, Felipe Borrero-Echeverry, Francisco Gonzalez, Marit Solum, Erika A. Wallin, Erik Hedenström, Bill S. Hansson, Anna-Lena Gustavsson, Marie Bengtsson, Göran Birgersson, William B. Walker III, Hany K. M. Dweck, Paul G. Becher and Peter Witzgall

    BMC Biology 2017 15:88

    Published on: 29 September 2017

  4. Research

    Genome sequencing of the staple food crop white Guinea yam enables the development of a molecular marker for sex determination

    Root and tuber crops are a major food source in tropical Africa. Among these crops are several species in the monocotyledonous genus Dioscorea collectively known as yam, a staple tuber crop that contributes enorm...

    Muluneh Tamiru, Satoshi Natsume, Hiroki Takagi, Benjamen White, Hiroki Yaegashi, Motoki Shimizu, Kentaro Yoshida, Aiko Uemura, Kaori Oikawa, Akira Abe, Naoya Urasaki, Hideo Matsumura, Pachakkil Babil, Shinsuke Yamanaka, Ryo Matsumoto, Satoru Muranaka…

    BMC Biology 2017 15:86

    Published on: 19 September 2017

  5. Review

    Antibiotic resistance: it’s bad, but why isn’t it worse?

    Antibiotic natural products are ancient and so is resistance. Consequently, environmental bacteria harbor numerous and varied antibiotic resistance elements. Nevertheless, despite long histories of antibiotic ...

    Nicholas Waglechner and Gerard D. Wright

    BMC Biology 2017 15:84

    Published on: 15 September 2017

  6. Question and Answer

    Q&A: Morphological insights into evolution

    In this question and answer article we discuss how evolution shapes morphology (the shape and pattern of our bodies) but also how learning about morphology, and specifically how that morphology arises during d...

    Neal Anthwal and Abigail S. Tucker

    BMC Biology 2017 15:83

    Published on: 15 September 2017

  7. Question and Answer

    Q&A: The brain under a mesoscope: the forest and the trees

    Neurons relevant to a particular behavior are often widely dispersed across the brain. To record activity in groups of individual neurons that might be distributed across large distances, neuroscientists and o...

    Nicholas James Sofroniew

    BMC Biology 2017 15:82

    Published on: 14 September 2017

  8. Research article

    Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps

    Members of the thioester-containing protein (TEP) family contribute to host defence in both insects and mammals. However, their role in the immune response of Drosophila is elusive. In this study, we address the ...

    Anna Dostálová, Samuel Rommelaere, Mickael Poidevin and Bruno Lemaitre

    BMC Biology 2017 15:79

    Published on: 5 September 2017

  9. Review

    Dosage-sensitive genes in evolution and disease

    For a subset of genes in our genome a change in gene dosage, by duplication or deletion, causes a phenotypic effect. These dosage-sensitive genes may confer an advantage upon copy number change, but more typic...

    Alan M. Rice and Aoife McLysaght

    BMC Biology 2017 15:78

    Published on: 1 September 2017

  10. Question and Answer

    Q&A: Where did the Neanderthals go?

    Genomic evidence has demonstrated that humans and Neanderthals interbred. Today, the genomes of most individuals outside Africa contain 2–3% Neanderthal DNA. However, it is still hotly debated why the Neandert...

    Kelley Harris and Rasmus Nielsen

    BMC Biology 2017 15:73

    Published on: 1 September 2017

  11. Research article

    Single-molecule sequencing and Hi-C-based proximity-guided assembly of amaranth (Amaranthus hypochondriacus) chromosomes provide insights into genome evolution

    Amaranth (Amaranthus hypochondriacus) was a food staple among the ancient civilizations of Central and South America that has recently received increased attention due to the high nutritional value of the seeds, ...

    D. J. Lightfoot, D. E. Jarvis, T. Ramaraj, R. Lee, E. N. Jellen and P. J. Maughan

    BMC Biology 2017 15:74

    Published on: 31 August 2017

  12. Research article

    Ribosome signatures aid bacterial translation initiation site identification

    While methods for annotation of genes are increasingly reliable, the exact identification of translation initiation sites remains a challenging problem. Since the N-termini of proteins often contain regulatory...

    Adam Giess, Veronique Jonckheere, Elvis Ndah, Katarzyna Chyżyńska, Petra Van Damme and Eivind Valen

    BMC Biology 2017 15:76

    Published on: 30 August 2017

  13. Research article

    A widespread family of polymorphic toxins encoded by temperate phages

    Polymorphic toxins (PTs) are multi-domain bacterial exotoxins belonging to distinct families that share common features in terms of domain organization. PTs are found in all major bacterial clades, including m...

    Anne Jamet, Marie Touchon, Bruno Ribeiro-Gonçalves, João André Carriço, Alain Charbit, Xavier Nassif, Mario Ramirez and Eduardo P. C. Rocha

    BMC Biology 2017 15:75

    Published on: 29 August 2017

  14. Erratum

    Erratum to: Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest species

    S. L. Pearce, D. F. Clarke, P. D. East, S. Elfekih, K. H. J. Gordon, L. S. Jermiin, A. McGaughran, J. G. Oakeshott, A. Papanicolaou, O. P. Perera, R. V. Rane, S. Richards, W. T. Tay, T. K. Walsh, A. Anderson, C. J. Anderson…

    BMC Biology 2017 15:69

    Published on: 15 August 2017

    The original article was published in BMC Biology 2017 15:63

  15. Research article

    The house spider genome reveals an ancient whole-genome duplication during arachnid evolution

    The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplic...

    Evelyn E. Schwager, Prashant P. Sharma, Thomas Clarke, Daniel J. Leite, Torsten Wierschin, Matthias Pechmann, Yasuko Akiyama-Oda, Lauren Esposito, Jesper Bechsgaard, Trine Bilde, Alexandra D. Buffry, Hsu Chao, Huyen Dinh, HarshaVardhan Doddapaneni, Shannon Dugan, Cornelius Eibner…

    BMC Biology 2017 15:62

    Published on: 31 July 2017

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