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  1. Organisms have evolved a range of phenotypic and genetic adaptations to live in different environments along an altitudinal gradient. Herein, we studied the widely distributed Chinese toad, Bufo gargarizans, as a...

    Authors: Yonggang Niu, Xuejing Zhang, Haiying Zhang, Shengkang Men, Tisen Xu, Li Ding, Xiangyong Li, Lei Wang, Huisong Wang, Kenneth B. Storey and Qiang Chen
    Citation: BMC Biology 2024 22:231
    Content type: Research article Published on:

  2. Evolutionary radiation is widely recognized as a mode of species diversification, but the drivers of the rapid diversification of fungi remain largely unknown. Here, we used Amanitaceae, one of the most divers...

    Authors: Qing Cai, Jean Evans I. Codjia, Bart Buyck, Yang-Yang Cui, Martin Ryberg, Nourou S. Yorou and Zhu L. Yang
    Citation: BMC Biology 2024 22:230
    Content type: Research article Published on:

  3. Mitochondrial genes and nuclear genes cooperate closely to maintain the functions of mitochondria, especially in the oxidative phosphorylation (OXPHOS) pathway. However, mitochondrial genes among arthropod lin...

    Authors: Yiyuan Li, Gregg W. C. Thomas, Stephen Richards, Robert M. Waterhouse, Xin Zhou and Michael E. Pfrender
    Citation: BMC Biology 2024 22:229
    Content type: Research article Published on:

  4. Authors: Siau Wei Bai, Maria Teresa Herrera-Abreu, Jennifer L Rohn, Victor Racine, Virginia Tajadura, Narendra Suryavanshi, Stephanie Bechtel, Stefan Wiemann, Buzz Baum and Anne J Ridley
    Citation: BMC Biology 2024 22:228
    Content type: Author Correction Published on:

    The original article was published in BMC Biology 2011 9:54

  5. Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting...

    Authors: Xiaoqiong Xia, Chaoyu Zhu, Fan Zhong and Lei Liu
    Citation: BMC Biology 2024 22:227
    Content type: Research article Published on:

  6. Drug repurposing is a promising approach in the field of drug discovery owing to its efficiency and cost-effectiveness. Most current drug repurposing models rely on specific datasets for training, which limits...

    Authors: Jinhang Wei, Linlin Zhuo, Xiangzheng Fu, XiangXiang Zeng, Li Wang, Quan Zou and Dongsheng Cao
    Citation: BMC Biology 2024 22:226
    Content type: Research Published on:

  7. Homologous recombination deficiency (HRD) is recognized as a pan-cancer predictive biomarker that potentially indicates who could benefit from treatment with PARP inhibitors (PARPi). Despite its clinical signi...

    Authors: Chiara Maria Lavinia Loeffler, Omar S. M. El Nahhas, Hannah Sophie Muti, Zunamys I. Carrero, Tobias Seibel, Marko van Treeck, Didem Cifci, Marco Gustav, Kevin Bretz, Nadine T. Gaisa, Kjong-Van Lehmann, Alexandra Leary, Pier Selenica, Jorge S. Reis-Filho, Nadina Ortiz-Bruechle and Jakob Nikolas Kather
    Citation: BMC Biology 2024 22:225
    Content type: Research article Published on:

  9. The phylum Nematoda is incredibly diverse and includes many parasites of humans, livestock, and plants. Peptide-activated G protein-coupled receptors (GPCRs) are central to the regulation of physiology and num...

    Authors: Luca Golinelli, Ellen Geens, Allister Irvine, Ciaran J. McCoy, Elke Vandewyer, Louise E. Atkinson, Angela Mousley, Liesbet Temmerman and Isabel Beets
    Citation: BMC Biology 2024 22:223
    Content type: Research article Published on:

  10. Abnormalities of in utero testis development are strongly associated with reproductive health conditions, including male infertility and testis cancer. In mouse testes, SOX9 and FGF9 support Sertoli cell developm...

    Authors: Rheannon O. Blücher, Rachel S. Lim, Matthew E. Ritchie and Patrick S. Western
    Citation: BMC Biology 2024 22:222
    Content type: Research article Published on:

  11. The growth factor receptor bound protein 7 (Grb7) family of signalling adaptor proteins comprises Grb7, Grb10 and Grb14. Each can interact with the insulin receptor and other receptor tyrosine kinases, where G...

    Authors: Kim Moorwood, Florentia M. Smith, Alastair S. Garfield, Michael Cowley, Lowenna J. Holt, Roger J. Daly and Andrew Ward
    Citation: BMC Biology 2024 22:221
    Content type: Research article Published on:

  12. Eukaryotic cells are highly compartmentalized by a variety of organelles that carry out specific cellular processes. The position of these organelles within the cell is elaborately regulated and vital for thei...

    Authors: Christopher Schmied, Michael Ebner, Paula Samsó, Rozemarijn Van Der Veen, Volker Haucke and Martin Lehmann
    Citation: BMC Biology 2024 22:220
    Content type: Methodology article Published on:

  13. Small RNA (sRNAs)- mediated RNA silencing is emerging as a key player in host-microbe interactions. However, its role in fungus-plant interactions relevant to biocontrol of plant diseases is yet to be explored...

    Authors: Edoardo Piombo, Ramesh Raju Vetukuri, Naga Charan Konakalla, Pruthvi B. Kalyandurg, Poorva Sundararajan, Dan Funck Jensen, Magnus Karlsson and Mukesh Dubey
    Citation: BMC Biology 2024 22:219
    Content type: Research article Published on:

  14. RNA-sequencing technology provides an effective tool for understanding miRNA regulation in complex human diseases, including cancers. A large number of computational methods have been developed to make use of ...

    Authors: Junpeng Zhang, Lin Liu, Xuemei Wei, Chunwen Zhao, Yanbi Luo, Jiuyong Li and Thuc Duy Le
    Citation: BMC Biology 2024 22:218
    Content type: Methodology article Published on:

  15. Diplomonads are anaerobic flagellates classified within Metamonada. They contain both host-associated commensals and parasites that reside in the intestinal tracts of animals, including humans (e.g., Giardia inte...

    Authors: Monika M. Wiśniewska, Eric D. Salomaki, Jeffrey D. Silberman, Kristina X. Terpis, Eva Mazancová, Petr Táborský, Vasana Jinatham, Eleni Gentekaki, Ivan Čepička and Martin Kolisko
    Citation: BMC Biology 2024 22:217
    Content type: Research article Published on:

  17. Zoology’s dark matter comprises hyperdiverse, poorly known taxa that are numerically dominant but largely unstudied, even in temperate regions where charismatic taxa are well understood. Dark taxa are everywhe...

    Authors: Emily Hartop, Leshon Lee, Amrita Srivathsan, Mirkka Jones, Pablo Peña-Aguilera, Otso Ovaskainen, Tomas Roslin and Rudolf Meier
    Citation: BMC Biology 2024 22:215
    Content type: Research Published on:

  18. The development of sequence-specific precision treatments like CRISPR gene editing therapies for Duchenne muscular dystrophy (DMD) requires sequence humanized animal models to enable the direct clinical transl...

    Authors: Yu C. J. Chey, Mark A. Corbett, Jayshen Arudkumar, Sandra G. Piltz, Paul Q. Thomas and Fatwa Adikusuma
    Citation: BMC Biology 2024 22:214
    Content type: Research Published on:

  20. Wnt signaling pathways play crucial roles in animal development. They establish embryonic axes, specify cell fates, and regulate tissue morphogenesis from the early embryo to organogenesis. It is becoming incr...

    Authors: Bruno C. Vellutini, José M. Martín-Durán, Aina Børve and Andreas Hejnol
    Citation: BMC Biology 2024 22:212
    Content type: Research article Published on:

  21. Phosphorus-solubilizing bacteria (PSB) are vital in converting insoluble phosphorus into a soluble form that plants can readily absorb and utilize in soil. While previous studies have mainly focused on the ext...

    Authors: Kaihong Bai, Wanying Wang, Jingnan Zhang, Pei Yao, Chuanying Cai, Zimei Xie, Laixin Luo, Tingting Li and Zhenlong Wang
    Citation: BMC Biology 2024 22:211
    Content type: Research Published on:

  23. Neutrophils, the most abundant leukocytes circulating in blood, contribute to host defense and play a significant role in chronic inflammatory disorders. They can release their DNA in the form of extracellular...

    Authors: Manijeh Khanmohammadi, Habiba Danish, Nadia Chandra Sekar, Sergio Aguilera Suarez, Chanly Chheang, Karlheinz Peter, Khashayar Khoshmanesh and Sara Baratchi
    Citation: BMC Biology 2024 22:209
    Content type: Research Published on:

  24. The natural light environment is far more complex than that experienced by animals under laboratory conditions. As a burrowing species, wild mice are able to self-modulate their light exposure, a concept known...

    Authors: Laura C. E. Steel, Shu K. E. Tam, Laurence A. Brown, Russell G. Foster and Stuart N. Peirson
    Citation: BMC Biology 2024 22:208
    Content type: Research article Published on:

  25. The importance of parental diet in relation to eventual offspring health is increasing in prominence due to the increased frequency of parents of reproductive age consuming poor diets. Whilst maternal health a...

    Authors: Hannah L. Morgan, Nader Eid, Nadine Holmes, Sonal Henson, Victoria Wright, Clare Coveney, Catherine Winder, Donna M. O’Neil, Warwick B. Dunn, David J. Boocock and Adam J. Watkins
    Citation: BMC Biology 2024 22:207
    Content type: Research article Published on:

  26. Diapause, a pivotal phase in the insect life cycle, enables survival during harsh environmental conditions. Unraveling the gene expression profiles of the diapause process helps uncover the molecular mechanism...

    Authors: Xingzhuo Yang, Xianguo Zhao, Zhangwu Zhao and Juan Du
    Citation: BMC Biology 2024 22:206
    Content type: Research article Published on:

  27. MicroRNA isoforms (isomiRs), tRNA-derived fragments (tRFs), and rRNA-derived fragments (rRFs) represent most of the small non-coding RNAs (sncRNAs) found in cells. Members of these three classes modulate messe...

    Authors: Tess Cherlin, Yi Jing, Siddhartha Shah, Anne Kennedy, Aristeidis G. Telonis, Venetia Pliatsika, Haley Wilson, Lily Thompson, Panagiotis I. Vlantis, Phillipe Loher, Benjamin Leiby and Isidore Rigoutsos
    Citation: BMC Biology 2024 22:205
    Content type: Research article Published on:

  28. Fusarium head blight (FHB) significantly impacts wheat yield and quality. Understanding the intricate interaction mechanisms between Fusarium graminearum (the main pathogen of FHB) and wheat is crucial for develo...

    Authors: Yazhou Zhang, Danyu Yao, Xinyu Yu, Xinyao Cheng, Lan Wen, Caihong Liu, Qiang Xu, Mei Deng, Qiantao Jiang, Pengfei Qi and Yuming Wei
    Citation: BMC Biology 2024 22:204
    Content type: Research Published on:

  29. Mutations occurring in nucleic acids or proteins may affect the binding affinities of protein-nucleic acid interactions. Although many efforts have been devoted to the impact of protein mutations, few computat...

    Authors: Si-Rui Xiao, Yao-Kun Zhang, Kai-Yu Liu, Yu-Xiang Huang and Rong Liu
    Citation: BMC Biology 2024 22:203
    Content type: Methodology article Published on:

  30. Seafood is increasingly traded worldwide, but its supply chain is particularly prone to frauds. To increase consumer confidence, prevent illegal trade, and provide independent validation for eco-labelling, acc...

    Authors: Luca Peruzza, Francesco Cicala, Massimo Milan, Giulia Dalla Rovere, Tomaso Patarnello, Luciano Boffo, Morgan Smits, Silvia Iori, Angelo De Bortoli, Federica Schiavon, Aurelio Zentilin, Piero Fariselli, Barbara Cardazzo and Luca Bargelloni
    Citation: BMC Biology 2024 22:202
    Content type: Research article Published on:

  31. Methods to suppress pest insect populations using genetic constructs and repeated releases of male homozygotes have recently been shown to be an attractive alternative to older sterile insect techniques based ...

    Authors: Jinyu Zhu, Jingheng Chen, Yiran Liu, Xuejiao Xu and Jackson Champer
    Citation: BMC Biology 2024 22:201
    Content type: Research article Published on:

  32. Kiwifruit, belonging to the genus Actinidia, represents a unique fruit crop characterized by its modern cultivars being genetically diverse and exhibiting remarkable variations in morphological traits and adap...

    Authors: Xiaolong Li, Liuqing Huo, Xinyi Li, Chaofan Zhang, Miaofeng Gu, Jialu Fan, Changbin Xu, Jinli Gong, Xiaoli Hu, Yi Zheng and Xuepeng Sun
    Citation: BMC Biology 2024 22:200
    Content type: Research Published on:

  33. Haem is essential but toxic for metazoan organisms. Auxotrophic nematodes can acquire sufficient haem from the environment or their hosts in the meanwhile eliminate or detoxify excessive haem through tightly c...

    Authors: Danni Tong, Fei Wu, Xueqiu Chen, Zhendong Du, Jingru Zhou, Jingju Zhang, Yi Yang, Aifang Du and Guangxu Ma
    Citation: BMC Biology 2024 22:199
    Content type: Research article Published on:

  34. The molecular mechanisms and signaling pathways involved in tooth morphogenesis have been the research focus in the fields of tooth and bone development. However, the cell population in molars at the late bell...

    Authors: Yingchun Zheng, Ting Lu, Leitao Zhang, Zhongzhi Gan, Aoxi Li, Chuandong He, Fei He, Sha He, Jian Zhang and Fu Xiong
    Citation: BMC Biology 2024 22:198
    Content type: Research article Published on:

  35. Cotton is an important economic crop and a host of Liriomyza sativae. Pectin methylesterase (PME)-mediated pectin metabolism plays an indispensable role in multiple biological processes in planta. However, the pl...

    Authors: Zheng Yang, Menglei Wang, Senmiao Fan, Zhen Zhang, Doudou Zhang, Jie He, Tongyi Li, Renhui Wei, Panpan Wang, Muhammad Dawood, Weijie Li, Lin Wang, Shaogan Wang, Youlu Yuan and Haihong Shang
    Citation: BMC Biology 2024 22:197
    Content type: Research article Published on:

  36. Baryscapus dioryctriae (Chalcidodea: Eulophidae) is a parasitic wasp that parasitizes the pupae of many Pyralidae members and has been used as a biological control agent against Dioryctria pests of pinecones.

    Authors: Xiaoyan Zhu, Yi Yang, Qiuyao Li, Jing Li, Lin Du, Yanhan Zhou, Hongbo Jin, Liwen Song, Qi Chen and Bingzhong Ren
    Citation: BMC Biology 2024 22:196
    Content type: Research article Published on:

  37. iPSC reprogramming technology exhibits significant promise in the realms of clinical therapeutics, disease modeling, pharmaceutical drug discovery, and various other applications. However, the extensive utiliz...

    Authors: Zhijing Zhang, Xinglin Hu, Yuchen Sun, Lei Lei and Zhonghua Liu
    Citation: BMC Biology 2024 22:195
    Content type: Research article Published on:

  38. DNA G-quadruplexes (G4s) represent a distinctive class of non-canonical DNA secondary structures. Despite their recognition as potential therapeutic targets in some cancers, the developmental role of G4 struct...

    Authors: Lijin Guo, Weiling Huang, Qi Wen, Siyu Zhang, Farhad Bordbar, Zhengzhong Xiao and Qinghua Nie
    Citation: BMC Biology 2024 22:194
    Content type: Research article Published on:

  39. Foxn1−/− deficient mice are a rare model of regenerative skin wound healing among mammals. In wounded skin, the transcription factor Foxn1 interacting with hypoxia-regulated factors affects re-epithelialization, ...

    Authors: Barbara Gawronska-Kozak, Sylwia Machcinska-Zielinska, Katarzyna Walendzik, Marta Kopcewicz, Mirva Pääkkönen and Joanna Wisniewska
    Citation: BMC Biology 2024 22:193
    Content type: Research article Published on:

  40. N6-Methyladenosine (m6A) methylation, a common form of RNA modification, play an important role in the pathogenesis of various diseases and in the ontogeny of organisms. Nevertheless, the precise function of m6A ...

    Authors: Yuanyuan Liu, Jian Li, Chenhui Wang, Jiangbo Li, Kai Luo, Kang Tao, Yuan Tian, Xiang Song, Zhifang Zhai, Yuandong Tao, Jia You, Lihua Wu, Wenqian Li, Yuanyuan Jiao, Rongya Yang and Mingwang Zhang
    Citation: BMC Biology 2024 22:192
    Content type: Research article Published on:

  41. Brassica napus L. (B. napus) is susceptible to waterlogging stress during different cultivation periods. Therefore, it is crucial to enhance the resistance to waterlogging stress to achieve a high and stable yiel...

    Authors: Jijun Li, Yuting Zhang, Yahui Chen, Yijing Wang, Zhihua Zhou, Jinxing Tu, Liang Guo and Xuan Yao
    Citation: BMC Biology 2024 22:191
    Content type: Research article Published on:

  42. Hemiptera is the fifth species-rich order of insects and the most species-rich order of hemimetabolous insects, including numerous insect species that are of agricultural or medical significance. Despite much ...

    Authors: Nan Song, Miao-Miao Wang, Wei-Chao Huang, Zhi-Yi Wu, Renfu Shao and Xin-Ming Yin
    Citation: BMC Biology 2024 22:190
    Content type: Research article Published on:

  43. The Zic family of transcription factors (TFs) promote both proliferation and maturation of cerebellar granule neurons (CGNs), raising the question of how a single, constitutively expressed TF family can suppor...

    Authors: Melyssa S. Minto, Jesús Emiliano Sotelo-Fonseca, Vijyendra Ramesh and Anne E. West
    Citation: BMC Biology 2024 22:189
    Content type: Research article Published on:

  44. The histone variant macroH2A (mH2A), the most deviant variant, is about threefold larger than the conventional histone H2A and consists of a histone H2A-like domain fused to a large Non-Histone Region responsi...

    Authors: Khalid Ouararhni, Flore Mietton, Jamal S. M. Sabir, Abdulkhaleg Ibrahim, Annie Molla, Raed S. Albheyri, Ali T. Zari, Ahmed Bahieldin, Hervé Menoni, Christian Bronner, Stefan Dimitrov and Ali Hamiche
    Citation: BMC Biology 2024 22:188
    Content type: Research article Published on:

  46. Habitat transitions have considerable consequences in organism homeostasis, as they require the adjustment of several concurrent physiological compartments to maintain stability and adapt to a changing environ...

    Authors: Raul Valente, Miguel Cordeiro, Bernardo Pinto, André Machado, Filipe Alves, Isabel Sousa-Pinto, Raquel Ruivo and L. Filipe C. Castro
    Citation: BMC Biology 2024 22:186
    Content type: Research article Published on:

  47. Scutellaria, a sub-cosmopolitan genus, stands as one of the Lamiaceae family’s largest genera, encompassing approximately 500 species found in both temperate and tropical montane regions. Recognized for its signi...

    Authors: Yinghui Wang, Chao Xu, Xing Guo, Yan Wang, Yanyi Chen, Jie Shen, Chunnian He, Yan Yu and Qiang Wang
    Citation: BMC Biology 2024 22:185
    Content type: Research article Published on:

  48. Pathologists commonly employ the Ki67 immunohistochemistry labelling index (LI) when deciding appropriate therapeutic strategies for patients with breast cancer. However, despite several attempts at standardiz...

    Authors: Natsuki Sato, Masahiko Tsujimoto, Masatoshi Nakatsuji, Hiromi Tsuji, Yuji Sugama, Kenzo Shimazu, Masafumi Shimoda and Hideki Ishihara
    Citation: BMC Biology 2024 22:181
    Content type: Methodology article Published on:

  49. Cell wall integrity (CWI) is crucial for fungal growth, pathogenesis, and adaptation to extracellular environments. Calcofluor white (CFW) is a cell wall perturbant that inhibits fungal growth, yet little is k...

    Authors: Jiyun Yang, Bing Li, Yu-Ting Pan, Ping Wang, Mei-Ling Sun, Ki-Tae Kim, Hui Sun, Jian-Ren Ye, Zhen Jiao, Yong-Hwan Lee and Lin Huang
    Citation: BMC Biology 2024 22:179
    Content type: Research article Published on:

  50. Casein kinase 1α (CK1α), expressed in both ovarian germ and somatic cells, is involved in the initial meiosis and primordial follicle formation of mouse oocytes. Using in vitro and in vivo experiments in this ...

    Authors: Xuan Luo, Di Zhang, Jiaming Zheng, Hui Liu, Longjie Sun, Hongzhou Guo, Lei Wang and Sheng Cui
    Citation: BMC Biology 2024 22:176
    Content type: Research article Published on:
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