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  2. Content type: Research article

    The spatial organization of the mammalian genome relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory...

    Authors: Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Nayuta Yakushiji-Kaminatsui, Asier Ullate-Agote and Denis Duboule

    Citation: BMC Biology 2019 17:55

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  3. Content type: Question and Answer

    Most cancer patients die due to metastasis formation. Therefore, understanding, preventing, and treating metastatic cancers is an unmet need. Recent research indicates that cancer cells that undergo metastasis...

    Authors: Sarah-Maria Fendt

    Citation: BMC Biology 2019 17:54

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  4. Content type: Review

    Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically ne...

    Authors: Payam A. Gammage and Christian Frezza

    Citation: BMC Biology 2019 17:53

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  7. Content type: Research article

    Identification of imprinted genes, demonstrating a consistent preference towards the paternal or maternal allelic expression, is important for the understanding of gene expression regulation during embryonic d...

    Authors: Bharati Jadhav, Ramin Monajemi, Kristina K. Gagalova, Daniel Ho, Harmen H. M. Draisma, Mark A. van de Wiel, Lude Franke, Bastiaan T. Heijmans, Joyce van Meurs, Rick Jansen, Peter A. C. ‘t Hoen, Andrew J. Sharp and Szymon M. Kiełbasa

    Citation: BMC Biology 2019 17:50

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  8. Content type: Research article

    Decisions in the cell that lead to its ultimate fate are important for fundamental cellular functions such as proliferation, growth, differentiation, development, and death. These cell fate decisions can be in...

    Authors: Zhenlong Jiang, Li Tian, Xiaona Fang, Kun Zhang, Qiong Liu, Qingzhe Dong, Erkang Wang and Jin Wang

    Citation: BMC Biology 2019 17:49

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  9. Content type: Comment

    Metagenomics allows exploration of aspects of a microbial community that were inaccessible by cultivation-based approaches targeting single microbes. Many new microbial taxa and genes have been discovered usin...

    Authors: Andrew Maltez Thomas and Nicola Segata

    Citation: BMC Biology 2019 17:48

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  10. Content type: Research article

    Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a fa...

    Authors: Amina Bouslimani, Ricardo da Silva, Tomasz Kosciolek, Stefan Janssen, Chris Callewaert, Amnon Amir, Kathleen Dorrestein, Alexey V. Melnik, Livia S. Zaramela, Ji-Nu Kim, Gregory Humphrey, Tara Schwartz, Karenina Sanders, Caitriona Brennan, Tal Luzzatto-Knaan, Gail Ackermann…

    Citation: BMC Biology 2019 17:47

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  11. Content type: Research article

    Ribosome biogenesis is a central process in every growing cell. In eukaryotes, it requires more than 250 non-ribosomal assembly factors, most of which are essential. Despite this large repertoire of potential ...

    Authors: Dominik Awad, Michael Prattes, Lisa Kofler, Ingrid Rössler, Mathias Loibl, Melanie Pertl, Gertrude Zisser, Heimo Wolinski, Brigitte Pertschy and Helmut Bergler

    Citation: BMC Biology 2019 17:46

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  12. Content type: Research article

    Environmental resistomes include transferable microbial genes. One important resistome component is resistance to arsenic, a ubiquitous and toxic metalloid that can have negative and chronic consequences for h...

    Authors: Taylor K. Dunivin, Susanna Y. Yeh and Ashley Shade

    Citation: BMC Biology 2019 17:45

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  13. Content type: Question and Answer

    Understanding the brain requires understanding behavior. New machine vision and learning techniques are poised to revolutionize our ability to analyze behaviors exhibited by animals in the laboratory. Here we ...

    Authors: Sandeep Robert Datta

    Citation: BMC Biology 2019 17:44

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  15. Content type: Research article

    At the beginning of mitosis, the cell forms a spindle made of microtubules and associated proteins to segregate chromosomes. An important part of spindle architecture is a set of antiparallel microtubule bundl...

    Authors: Lora Winters, Ivana Ban, Marcel Prelogović, Iana Kalinina, Nenad Pavin and Iva M. Tolić

    Citation: BMC Biology 2019 17:42

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  16. Content type: Methodology article

    Intrabodies enable targeting of proteins in live cells, but generating specific intrabodies against the thousands of proteins in a proteome poses a challenge. We leverage the widespread availability of fluores...

    Authors: David L. Prole and Colin W. Taylor

    Citation: BMC Biology 2019 17:41

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  17. Content type: Research article

    The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery. A broad range of translation i...

    Authors: Yuri Frosi, Rachael Usher, Dawn Thean Gek Lian, David P. Lane and Christopher J. Brown

    Citation: BMC Biology 2019 17:40

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  18. Content type: Research article

    RNA regulation by RNA-binding proteins (RBPs) involve extremely complicated mechanisms. MOV10 and MOV10L1 are two homologous RNA helicases implicated in distinct intracellular pathways. MOV10L1 participates sp...

    Authors: Kaiqiang Fu, Suwen Tian, Huanhuan Tan, Caifeng Wang, Hanben Wang, Min Wang, Yuanyuan Wang, Zhen Chen, Yanfeng Wang, Qiuling Yue, Qiushi Xu, Shuya Zhang, Haixin Li, Jie Xie, Mingyan Lin, Mengcheng Luo…

    Citation: BMC Biology 2019 17:39

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  19. Content type: Methodology article

    Many methods have been developed to quantify cell shape in 2D in tissues. For instance, the analysis of epithelial cells in Drosophila embryogenesis or jigsaw puzzle-shaped pavement cells in plant epidermis ha...

    Authors: Özer Erguvan, Marion Louveaux, Olivier Hamant and Stéphane Verger

    Citation: BMC Biology 2019 17:38

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  22. Content type: Research article

    The mammalian epididymis is responsible for the provision of a highly specialized environment in which spermatozoa acquire functional maturity and are subsequently stored in preparation for ejaculation. Making...

    Authors: Wei Zhou, Simone J. Stanger, Amanda L. Anderson, Ilana R. Bernstein, Geoffry N. De Iuliis, Adam McCluskey, Eileen A. McLaughlin, Matthew D. Dun and Brett Nixon

    Citation: BMC Biology 2019 17:35

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  23. Content type: Research article

    Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation ...

    Authors: Liliane Abuin, Lucia L. Prieto-Godino, Haiyun Pan, Craig Gutierrez, Lan Huang, Rongsheng Jin and Richard Benton

    Citation: BMC Biology 2019 17:34

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  24. Content type: Research article

    Large animal models, such as the dog, are increasingly being used for studying diseases including gastrointestinal (GI) disorders. Dogs share similar environmental, genomic, anatomical, and intestinal physiolo...

    Authors: Lawrance Chandra, Dana C. Borcherding, Dawn Kingsbury, Todd Atherly, Yoko M. Ambrosini, Agnes Bourgois-Mochel, Wang Yuan, Michael Kimber, Yijun Qi, Qun Wang, Michael Wannemuehler, N. Matthew Ellinwood, Elizabeth Snella, Martin Martin, Melissa Skala, David Meyerholz…

    Citation: BMC Biology 2019 17:33

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  25. Content type: Research article

    Epigenetic mechanisms play fundamental roles in brain function and behavior and stressors such as social isolation can alter animal behavior via epigenetic mechanisms. However, due to cellular heterogeneity, i...

    Authors: Pavan Agrawal, Phuong Chung, Ulrike Heberlein and Clement Kent

    Citation: BMC Biology 2019 17:30

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  27. Content type: Research article

    Antibiotic resistance is rendering common bacterial infections untreatable. Wildlife can incorporate and disperse antibiotic-resistant bacteria in the environment, such as water systems, which in turn serve as...

    Authors: Vanessa R. Marcelino, Michelle Wille, Aeron C. Hurt, Daniel González-Acuña, Marcel Klaassen, Timothy E. Schlub, John-Sebastian Eden, Mang Shi, Jonathan R. Iredell, Tania C. Sorrell and Edward C. Holmes

    Citation: BMC Biology 2019 17:31

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  28. Content type: Research article

    The processing of optic flow in the pretectum/accessory optic system allows animals to stabilize retinal images by executing compensatory optokinetic and optomotor behavior. The success of this behavior depend...

    Authors: Kun Wang, Julian Hinz, Väinö Haikala, Dierk F. Reiff and Aristides B. Arrenberg

    Citation: BMC Biology 2019 17:29

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  29. Content type: Research article

    Unique among cnidarians, jellyfish have remarkable morphological and biochemical innovations that allow them to actively hunt in the water column and were some of the first animals to become free-swimming. The...

    Authors: Hak-Min Kim, Jessica A. Weber, Nayoung Lee, Seung Gu Park, Yun Sung Cho, Youngjune Bhak, Nayun Lee, Yeonsu Jeon, Sungwon Jeon, Victor Luria, Amir Karger, Marc W. Kirschner, Ye Jin Jo, Seonock Woo, Kyoungsoon Shin, Oksung Chung…

    Citation: BMC Biology 2019 17:28

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  31. Content type: Comment

    Few would argue that science is better done in silos, with no transparency or sharing of methods and resources. Yet scientists and scientific stakeholders (e.g., academic institutions, funding agencies, journa...

    Authors: Michael P. Milham and Arno Klein

    Citation: BMC Biology 2019 17:27

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  32. Content type: Correction

    Upon publication of the original article [1], the authors noticed that they omitted Additional file 16: Table S10 from the Additional file list. Additional file 16: Table S10 can be found attached to this Corr...

    Authors: Zhibo Cui, Aizi Tong, Yiqiong Huo, Zhiqiang Yan, Wenqi Yang, Xianli Yang and Xiao-Xue Wang

    Citation: BMC Biology 2019 17:25

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    The original article was published in BMC Biology 2017 15:80

  33. Content type: Research article

    The nematode Caenorhabditis elegans has been extensively used to explore the relationships between complex traits, genotypes, and environments. Complex traits can vary across different genotypes of a species, and...

    Authors: Basten L. Snoek, Rita J. M. Volkers, Harm Nijveen, Carola Petersen, Philipp Dirksen, Mark G. Sterken, Rania Nakad, Joost A. G. Riksen, Philip Rosenstiel, Jana J. Stastna, Bart P. Braeckman, Simon C. Harvey, Hinrich Schulenburg and Jan E. Kammenga

    Citation: BMC Biology 2019 17:24

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  34. Content type: Research article

    Female mammals have a limited reproductive lifespan determined by the size of the primordial follicle pool established perinatally. Over two thirds of fetal oocytes are abolished via programmed cell death duri...

    Authors: Jia Wen, Hao Yan, Meina He, Tuo Zhang, Xinyi Mu, Haibin Wang, Hua Zhang, Guoliang Xia and Chao Wang

    Citation: BMC Biology 2019 17:23

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  35. Content type: Research article

    Although the overall brain organization is shared in vertebrates, there are significant differences within subregions among different groups, notably between Sarcopterygii (lobe-finned fish) and Actinopterygii...

    Authors: Solal Bloch, Manon Thomas, Ingrid Colin, Sonya Galant, Elodie Machado, Pierre Affaticati, Arnim Jenett and Kei Yamamoto

    Citation: BMC Biology 2019 17:22

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  37. Content type: Research article

    Microbial communities are susceptible to the public goods dilemma, whereby individuals can gain an advantage within a group by utilizing, but not sharing the cost of producing, public goods. In bacteria, the d...

    Authors: Kelei Zhao, Linjie Liu, Xiaojie Chen, Ting Huang, Lianming Du, Jiafu Lin, Yang Yuan, Yingshun Zhou, Bisong Yue, Kun Wei and Yiwen Chu

    Citation: BMC Biology 2019 17:20

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  38. Content type: Research article

    Spironucleus salmonicida is an anaerobic parasite that can cause systemic infections in Atlantic salmon. Unlike other diplomonad parasites, such as the human pathogen Giardia intestinalis, Spironucleus species ca...

    Authors: Courtney W. Stairs, Anna Kokla, Ásgeir Ástvaldsson, Jon Jerlström-Hultqvist, Staffan Svärd and Thijs J. G. Ettema

    Citation: BMC Biology 2019 17:19

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  39. Content type: Research article

    Nematodes represent important pathogens of humans and farmed animals and cause significant health and economic impacts. The control of nematodes is primarily carried out by applying a limited number of anthelm...

    Authors: Antony P. Page, Mark Roberts, Marie-Anne Félix, Derek Pickard, Andrew Page and William Weir

    Citation: BMC Biology 2019 17:10

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  40. Content type: Question and Answer

    Farmers around the world have recently experienced significant crop losses due to severe heat and drought. Such extreme weather events and the need to feed a rapidly growing population have raised concerns for...

    Authors: Kai P. Voss-Fels, Andreas Stahl and Lee T. Hickey

    Citation: BMC Biology 2019 17:18

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  41. Content type: Comment

    Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shape...

    Authors: Timothy E. Saunders and Philip W. Ingham

    Citation: BMC Biology 2019 17:17

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  42. Content type: Research article

    Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminth...

    Authors: Gregory A. Cary, Andrew Wolff, Olga Zueva, Joseph Pattinato and Veronica F. Hinman

    Citation: BMC Biology 2019 17:16

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  43. Content type: Commentary

    A paper published in BMC Biology characterises biophysically oligomeric and filamentous structures formed spontaneously by the Toll-like receptor signalling adaptor MyD88. Naturally occurring mutants of MyD88 tha...

    Authors: Nicholas J. Gay

    Citation: BMC Biology 2019 17:15

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    The original article was published in BMC Biology 2018 16:149

  44. Content type: Research article

    Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in...

    Authors: Alper Akay, David Jordan, Isabela Cunha Navarro, Tomasz Wrzesinski, Chris P. Ponting, Eric A. Miska and Wilfried Haerty

    Citation: BMC Biology 2019 17:14

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  46. Content type: Research article

    Notch-Delta signaling functions across a wide array of animal systems to break symmetry in a sheet of undifferentiated cells and generate cells with different fates, a process known as lateral inhibition. Unli...

    Authors: Ginger L. Hunter, Li He, Norbert Perrimon, Guillaume Charras, Edward Giniger and Buzz Baum

    Citation: BMC Biology 2019 17:12

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  47. Content type: Research article

    Photosynthetic euglenids are major contributors to fresh water ecosystems. Euglena gracilis in particular has noted metabolic flexibility, reflected by an ability to thrive in a range of harsh environments. E. gr...

    Authors: ThankGod E. Ebenezer, Martin Zoltner, Alana Burrell, Anna Nenarokova, Anna M. G. Novák Vanclová, Binod Prasad, Petr Soukal, Carlos Santana-Molina, Ellis O’Neill, Nerissa N. Nankissoor, Nithya Vadakedath, Viktor Daiker, Samson Obado, Sara Silva-Pereira, Andrew P. Jackson, Damien P. Devos…

    Citation: BMC Biology 2019 17:11

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  48. Content type: Research article

    CRISPR-Cas12a (formerly Cpf1) is an RNA-guided endonuclease with distinct features that have expanded genome editing capabilities. Cas12a-mediated genome editing is temperature sensitive in plants, but a lack ...

    Authors: Aimee A. Malzahn, Xu Tang, Keunsub Lee, Qiurong Ren, Simon Sretenovic, Yingxiao Zhang, Hongqiao Chen, Minjeong Kang, Yu Bao, Xuelian Zheng, Kejun Deng, Tao Zhang, Valeria Salcedo, Kan Wang, Yong Zhang and Yiping Qi

    Citation: BMC Biology 2019 17:9

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  49. Content type: Research article

    In socially monogamous species, reproduction is not always confined to paired males and females. Extra-pair males commonly also reproduce with paired females, which is traditionally thought to be costly to the...

    Authors: Aneesh P. H. Bose, Jonathan M. Henshaw, Holger Zimmermann, Karoline Fritzsche and Kristina M. Sefc

    Citation: BMC Biology 2019 17:2

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  50. Content type: Review

    Photosynthesis and nitrogen fixation became evolutionarily immutable as “frozen metabolic accidents” because multiple interactions between the proteins and protein complexes involved led to their co-evolution ...

    Authors: Dario Leister

    Citation: BMC Biology 2019 17:8

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