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  1. Content type: Research article

    The selection pressure exercised by antibiotic drugs is an important consideration for the wise stewardship of antimicrobial treatment programs. Treatment decisions are currently based on crude assumptions, an...

    Authors: Matthias Willmann, Maria J. G. T. Vehreschild, Lena M. Biehl, Wichard Vogel, Daniela Dörfel, Axel Hamprecht, Harald Seifert, Ingo B. Autenrieth and Silke Peter

    Citation: BMC Biology 2019 17:76

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  2. Content type: Research article

    Cassava is an important food crop in tropical and sub-tropical regions worldwide. In Africa, cassava production is widely affected by cassava mosaic disease (CMD), which is caused by the African cassava mosaic...

    Authors: Joel-E. Kuon, Weihong Qi, Pascal Schläpfer, Matthias Hirsch-Hoffmann, Philipp Rogalla von Bieberstein, Andrea Patrignani, Lucy Poveda, Stefan Grob, Miyako Keller, Rie Shimizu-Inatsugi, Ueli Grossniklaus, Hervé Vanderschuren and Wilhelm Gruissem

    Citation: BMC Biology 2019 17:75

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  3. Content type: Research article

    In mammals, cold exposure induces browning of white adipose tissue (WAT) and alters WAT gene expression and lipid metabolism to boost adaptive thermogenesis and maintain body temperature. Understanding the lip...

    Authors: Ziye Xu, Wenjing You, Yanbing Zhou, Wentao Chen, Yizhen Wang and Tizhong Shan

    Citation: BMC Biology 2019 17:74

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  4. Content type: Research article

    Spindle microtubule organization, regulated by microtubule-associated proteins, is critical for cell division. Proper organization of kinetochore fiber (K-fiber), connecting spindle poles and kinetochores, is ...

    Authors: Haining Zhou, Tao Zheng, Tianning Wang, Qi Li, Fulin Wang, Xin Liang, Jianguo Chen and Junlin Teng

    Citation: BMC Biology 2019 17:73

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  5. Content type: Methodology article

    Microbial contamination poses a major difficulty for successful data analysis in biological and biomedical research. Computational approaches utilizing next-generation sequencing (NGS) data offer promising dia...

    Authors: Sung-Joon Park, Satoru Onizuka, Masahide Seki, Yutaka Suzuki, Takanori Iwata and Kenta Nakai

    Citation: BMC Biology 2019 17:72

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  6. Content type: Review

    As a “holy grail” of neuroscience, optical imaging of membrane potential could enable high resolution measurements of spiking and synaptic activity in neuronal populations. This has been partly achieved using ...

    Authors: Yuki Bando, Christiane Grimm, Victor H Cornejo and Rafael Yuste

    Citation: BMC Biology 2019 17:71

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  7. Content type: Research article

    Strigolactones (SLs) are an important class of carotenoid-derived signalling molecule in plants, which function both as exogenous signals in the rhizosphere and as endogenous plant hormones. In flowering plant...

    Authors: Catriona H. Walker, Karen Siu-Ting, Alysha Taylor, Mary J. O’Connell and Tom Bennett

    Citation: BMC Biology 2019 17:70

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  8. Content type: Research article

    The planetary sulfur cycle is a complex web of chemical reactions that can be microbial-mediated or can occur spontaneously in the environment, depending on the temperature and pH. Inorganic sulfur compounds c...

    Authors: Charlotte D. Vavourakis, Maliheh Mehrshad, Cherel Balkema, Rutger van Hall, Adrian-Ştefan Andrei, Rohit Ghai, Dimitry Y. Sorokin and Gerard Muyzer

    Citation: BMC Biology 2019 17:69

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  9. Content type: Research article

    The functional annotation of genomes, including chromatin accessibility and modifications, is important for understanding and effectively utilizing the increased amount of genome sequences reported. However, w...

    Authors: Lingzhao Fang, Shuli Liu, Mei Liu, Xiaolong Kang, Shudai Lin, Bingjie Li, Erin E. Connor, Ransom L. Baldwin VI, Albert Tenesa, Li Ma, George E. Liu and Cong-jun Li

    Citation: BMC Biology 2019 17:68

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  10. Content type: Research article

    Arthropod eyes have diversified during evolution to serve multiple needs, such as finding mates, hunting prey and navigating in complex surroundings under varying light conditions. This diversity is reflected ...

    Authors: Ana Patricia Ramos, Ola Gustafsson, Nicolas Labert, Iris Salecker, Dan-Eric Nilsson and Michalis Averof

    Citation: BMC Biology 2019 17:67

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  11. Content type: Research article

    Voltage-gated sodium (Nav) channels have traditionally been considered a trademark of excitable cells. However, recent studies have shown the presence of Nav channels in several non-excitable cells, such as astro...

    Authors: Julia K. Johansson, Viivi I. Karema-Jokinen, Satu Hakanen, Antti Jylhä, Hannu Uusitalo, Maija Vihinen-Ranta, Heli Skottman, Teemu O. Ihalainen and Soile Nymark

    Citation: BMC Biology 2019 17:63

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  12. Content type: Methodology article

    We describe a new approach to the recovery of information from faecal samples, based on the analysis of the molecular signature generated by rapid evaporative ionisation mass spectrometry (REIMS).

    Authors: Nicola B. Davidson, Natalie I. Koch, Joscelyn Sarsby, Emrys Jones, Jane L. Hurst and Robert J. Beynon

    Citation: BMC Biology 2019 17:66

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  13. Content type: Methodology article

    Effective disease management depends on timely and accurate diagnosis to guide control measures. The capacity to distinguish between individuals in a pathogen population with specific properties such as fungic...

    Authors: Guru V. Radhakrishnan, Nicola M. Cook, Vanessa Bueno-Sancho, Clare M. Lewis, Antoine Persoons, Abel Debebe Mitiku, Matthew Heaton, Phoebe E. Davey, Bekele Abeyo, Yoseph Alemayehu, Ayele Badebo, Marla Barnett, Ruth Bryant, Jeron Chatelain, Xianming Chen, Suomeng Dong…

    Citation: BMC Biology 2019 17:65

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  14. Content type: Review

    Cell-free systems (CFS) have recently evolved into key platforms for synthetic biology applications. Many synthetic biology tools have traditionally relied on cell-based systems, and while their adoption has s...

    Authors: Aidan Tinafar, Katariina Jaenes and Keith Pardee

    Citation: BMC Biology 2019 17:64

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  15. Content type: Research article

    Vasopressin/oxytocin (VP/OT)-type neuropeptides are well known for their roles as regulators of diuresis, reproductive physiology and social behaviour. However, our knowledge of their functions is largely base...

    Authors: Esther A. Odekunle, Dean C. Semmens, Nataly Martynyuk, Ana B. Tinoco, Abdullah K. Garewal, Radhika R. Patel, Liisa M. Blowes, Meet Zandawala, Jérôme Delroisse, Susan E. Slade, James H. Scrivens, Michaela Egertová and Maurice R. Elphick

    Citation: BMC Biology 2019 17:60

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  17. Content type: Research article

    FoxH1 is a forkhead transcription factor with conserved key functions in vertebrate mesoderm induction and left-right patterning downstream of the TGF-beta/Nodal signaling pathway. Binding of the forkhead doma...

    Authors: Patrick Fischer, Hao Chen, Frederic Pacho, Dietmar Rieder, Robin A. Kimmel and Dirk Meyer

    Citation: BMC Biology 2019 17:61

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  18. Content type: Review

    This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate. We discuss metabolic rewiring caused by viruses, the influe...

    Authors: Shivani K. Thaker, James Ch’ng and Heather R. Christofk

    Citation: BMC Biology 2019 17:59

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  22. Content type: Research article

    The spatial organization of the mammalian genome relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory...

    Authors: Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Nayuta Yakushiji-Kaminatsui, Asier Ullate-Agote and Denis Duboule

    Citation: BMC Biology 2019 17:55

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  23. Content type: Question and Answer

    Most cancer patients die due to metastasis formation. Therefore, understanding, preventing, and treating metastatic cancers is an unmet need. Recent research indicates that cancer cells that undergo metastasis...

    Authors: Sarah-Maria Fendt

    Citation: BMC Biology 2019 17:54

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  24. Content type: Review

    Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically ne...

    Authors: Payam A. Gammage and Christian Frezza

    Citation: BMC Biology 2019 17:53

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  27. Content type: Research article

    Identification of imprinted genes, demonstrating a consistent preference towards the paternal or maternal allelic expression, is important for the understanding of gene expression regulation during embryonic d...

    Authors: Bharati Jadhav, Ramin Monajemi, Kristina K. Gagalova, Daniel Ho, Harmen H. M. Draisma, Mark A. van de Wiel, Lude Franke, Bastiaan T. Heijmans, Joyce van Meurs, Rick Jansen, Peter A. C. ‘t Hoen, Andrew J. Sharp and Szymon M. Kiełbasa

    Citation: BMC Biology 2019 17:50

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  28. Content type: Research article

    Decisions in the cell that lead to its ultimate fate are important for fundamental cellular functions such as proliferation, growth, differentiation, development, and death. These cell fate decisions can be in...

    Authors: Zhenlong Jiang, Li Tian, Xiaona Fang, Kun Zhang, Qiong Liu, Qingzhe Dong, Erkang Wang and Jin Wang

    Citation: BMC Biology 2019 17:49

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  29. Content type: Comment

    Metagenomics allows exploration of aspects of a microbial community that were inaccessible by cultivation-based approaches targeting single microbes. Many new microbial taxa and genes have been discovered usin...

    Authors: Andrew Maltez Thomas and Nicola Segata

    Citation: BMC Biology 2019 17:48

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  30. Content type: Research article

    Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a fa...

    Authors: Amina Bouslimani, Ricardo da Silva, Tomasz Kosciolek, Stefan Janssen, Chris Callewaert, Amnon Amir, Kathleen Dorrestein, Alexey V. Melnik, Livia S. Zaramela, Ji-Nu Kim, Gregory Humphrey, Tara Schwartz, Karenina Sanders, Caitriona Brennan, Tal Luzzatto-Knaan, Gail Ackermann…

    Citation: BMC Biology 2019 17:47

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  31. Content type: Research article

    Ribosome biogenesis is a central process in every growing cell. In eukaryotes, it requires more than 250 non-ribosomal assembly factors, most of which are essential. Despite this large repertoire of potential ...

    Authors: Dominik Awad, Michael Prattes, Lisa Kofler, Ingrid Rössler, Mathias Loibl, Melanie Pertl, Gertrude Zisser, Heimo Wolinski, Brigitte Pertschy and Helmut Bergler

    Citation: BMC Biology 2019 17:46

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  32. Content type: Research article

    Environmental resistomes include transferable microbial genes. One important resistome component is resistance to arsenic, a ubiquitous and toxic metalloid that can have negative and chronic consequences for h...

    Authors: Taylor K. Dunivin, Susanna Y. Yeh and Ashley Shade

    Citation: BMC Biology 2019 17:45

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  33. Content type: Question and Answer

    Understanding the brain requires understanding behavior. New machine vision and learning techniques are poised to revolutionize our ability to analyze behaviors exhibited by animals in the laboratory. Here we ...

    Authors: Sandeep Robert Datta

    Citation: BMC Biology 2019 17:44

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  35. Content type: Research article

    At the beginning of mitosis, the cell forms a spindle made of microtubules and associated proteins to segregate chromosomes. An important part of spindle architecture is a set of antiparallel microtubule bundl...

    Authors: Lora Winters, Ivana Ban, Marcel Prelogović, Iana Kalinina, Nenad Pavin and Iva M. Tolić

    Citation: BMC Biology 2019 17:42

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  36. Content type: Methodology article

    Intrabodies enable targeting of proteins in live cells, but generating specific intrabodies against the thousands of proteins in a proteome poses a challenge. We leverage the widespread availability of fluores...

    Authors: David L. Prole and Colin W. Taylor

    Citation: BMC Biology 2019 17:41

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  37. Content type: Research article

    The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery. A broad range of translation i...

    Authors: Yuri Frosi, Rachael Usher, Dawn Thean Gek Lian, David P. Lane and Christopher J. Brown

    Citation: BMC Biology 2019 17:40

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  38. Content type: Research article

    RNA regulation by RNA-binding proteins (RBPs) involve extremely complicated mechanisms. MOV10 and MOV10L1 are two homologous RNA helicases implicated in distinct intracellular pathways. MOV10L1 participates sp...

    Authors: Kaiqiang Fu, Suwen Tian, Huanhuan Tan, Caifeng Wang, Hanben Wang, Min Wang, Yuanyuan Wang, Zhen Chen, Yanfeng Wang, Qiuling Yue, Qiushi Xu, Shuya Zhang, Haixin Li, Jie Xie, Mingyan Lin, Mengcheng Luo…

    Citation: BMC Biology 2019 17:39

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  39. Content type: Methodology article

    Many methods have been developed to quantify cell shape in 2D in tissues. For instance, the analysis of epithelial cells in Drosophila embryogenesis or jigsaw puzzle-shaped pavement cells in plant epidermis ha...

    Authors: Özer Erguvan, Marion Louveaux, Olivier Hamant and Stéphane Verger

    Citation: BMC Biology 2019 17:38

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  42. Content type: Research article

    The mammalian epididymis is responsible for the provision of a highly specialized environment in which spermatozoa acquire functional maturity and are subsequently stored in preparation for ejaculation. Making...

    Authors: Wei Zhou, Simone J. Stanger, Amanda L. Anderson, Ilana R. Bernstein, Geoffry N. De Iuliis, Adam McCluskey, Eileen A. McLaughlin, Matthew D. Dun and Brett Nixon

    Citation: BMC Biology 2019 17:35

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  43. Content type: Research article

    Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation ...

    Authors: Liliane Abuin, Lucia L. Prieto-Godino, Haiyun Pan, Craig Gutierrez, Lan Huang, Rongsheng Jin and Richard Benton

    Citation: BMC Biology 2019 17:34

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  44. Content type: Research article

    Large animal models, such as the dog, are increasingly being used for studying diseases including gastrointestinal (GI) disorders. Dogs share similar environmental, genomic, anatomical, and intestinal physiolo...

    Authors: Lawrance Chandra, Dana C. Borcherding, Dawn Kingsbury, Todd Atherly, Yoko M. Ambrosini, Agnes Bourgois-Mochel, Wang Yuan, Michael Kimber, Yijun Qi, Qun Wang, Michael Wannemuehler, N. Matthew Ellinwood, Elizabeth Snella, Martin Martin, Melissa Skala, David Meyerholz…

    Citation: BMC Biology 2019 17:33

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  45. Content type: Research article

    Epigenetic mechanisms play fundamental roles in brain function and behavior and stressors such as social isolation can alter animal behavior via epigenetic mechanisms. However, due to cellular heterogeneity, i...

    Authors: Pavan Agrawal, Phuong Chung, Ulrike Heberlein and Clement Kent

    Citation: BMC Biology 2019 17:30

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  47. Content type: Research article

    Antibiotic resistance is rendering common bacterial infections untreatable. Wildlife can incorporate and disperse antibiotic-resistant bacteria in the environment, such as water systems, which in turn serve as...

    Authors: Vanessa R. Marcelino, Michelle Wille, Aeron C. Hurt, Daniel González-Acuña, Marcel Klaassen, Timothy E. Schlub, John-Sebastian Eden, Mang Shi, Jonathan R. Iredell, Tania C. Sorrell and Edward C. Holmes

    Citation: BMC Biology 2019 17:31

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  48. Content type: Research article

    The processing of optic flow in the pretectum/accessory optic system allows animals to stabilize retinal images by executing compensatory optokinetic and optomotor behavior. The success of this behavior depend...

    Authors: Kun Wang, Julian Hinz, Väinö Haikala, Dierk F. Reiff and Aristides B. Arrenberg

    Citation: BMC Biology 2019 17:29

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  49. Content type: Research article

    Unique among cnidarians, jellyfish have remarkable morphological and biochemical innovations that allow them to actively hunt in the water column and were some of the first animals to become free-swimming. The...

    Authors: Hak-Min Kim, Jessica A. Weber, Nayoung Lee, Seung Gu Park, Yun Sung Cho, Youngjune Bhak, Nayun Lee, Yeonsu Jeon, Sungwon Jeon, Victor Luria, Amir Karger, Marc W. Kirschner, Ye Jin Jo, Seonock Woo, Kyoungsoon Shin, Oksung Chung…

    Citation: BMC Biology 2019 17:28

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