The LAMP protein family. (A) Domain architectures of the five human LAMP family proteins (UniProt P11279, P13473, Q9UQV4, Q9UJQ1, P34810). O- and N-linked glycosylation sites are indicated in blue and red, respectively. SP, signal peptide; TM, transmembrane helix. (B, C) Sequence alignments of the seven human LAMP domains and adjacent transmembrane domains (B) and of the 'hinge' region (linker) connecting the membrane-distal ('dist') and membrane-proximal ('prox') domains of LAMP-1 and LAMP-2 (C). Glycosylated residues are displayed with yellow background. Residues involved in β-bulges are indicated by arcs in magenta. Hydrophobic residues are colored red and hydrophilic ones are colored blue (in B). S-S: disulfide bond.