Figure 2

Ovaries of Amhr2-Cre/+;Notch2^flox/- mice contain multi-oocyte follicles that become hemorrhagic. (A, C, E) Littermate controls; (B, D, F) Amhr2-Cre/+;Notch2^flox/- mutants. (A, B) Multi-oocyte follicles were present in 3-week-old Amhr2-Cre/+;Notch2^flox/- female mice (B. arrowheads). (C-F) Follicles in Amhr2-Cre/+;Notch2^flox/- females became hemorrhagic by approximately 7 weeks of age (D, F, arrows).