A functional genomics screen for microRNA regulators of NF-kappaB signaling

Table 2 High confidence functional targets from miRNA predictions and genome-wide cDNA screen.

miRNAs repressing NF-κB signaling
miRNA	Gene	Transcripts	CS	CSP
miR-24	MYD88	NM_001172569, NM_002468, NM_001172568, NM_001172567, NM_001172566	-0.319	95
	RASL11B	NM_023940	-0.35	96
	RELA	NM_021975, NM_001145138	-0.307	93
miR-124	TRIM22	NM_001199573, NM_006074	-0.339	96
	BECN1	NM_003766	-0.339	96
miR-210	CCNL2	NM_001039577	-0.275	85
miR-491	PLEKHB1	NM_021200, NM_001130033, NM_001130035, NM_001130034, NM_001130036	-0.314	98
	TULP3	NM_003324	-0.278	97
	TNFSF10	NM_001190943	-0.336	99
miR-506	RELA	NM_021975, NM_001145138	-0.401	98
miRNAs activating NF-κB signaling
miRNA	Gene	Transcripts	CS	CSP
	MATN2	NM_030583, NM_002380	-0.351	96
miR-30a	GPR161	NM_153832	-0.298	93
	PTGER2	NM_000956	-0.328	95
miR-34b	TLR7	NM_016562	-0.356	98
miR-125b	IKBKG	NM_001099857, NM_001099856, NM_001145255	-0.297	92
	MAP3K11	NM_002419	-0.337	95
miR-141	PTGDR	NM_000953	-0.3	97
miR-184	TNK2	NM_001010938, NM_005781	-0.452	94
	SLC7A5	NM_003486	-0.306	85
miR-452*	LPAR2	NM_004720	-0.304	95
	STMN1	NM_001145454	-0.367	98
	NFKBIE	NM_004556	-0.288	94
miR-544	TSPAN13	NM_014399	-0.279	92

CS, context score; CSP, context score percentile; miRNAs, microRNAs; NF-κB, nuclear factor-kappa B. A more negative CS is associated with a more favorable miRNA-mRNA interaction.

ISSN: 1741-7007