Figure 4
From: DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
p53 transcriptional activity and its effect on cell fate. (a) Gene expression of a set of well-known p53 target genes by real-time quantitative (q)PCR analysis in U-2 OS cells treated with 1 μmol/l (filled columns) and 100 μmol/l (empty columns) etoposide, respectively. Error bars show standard deviations of data from three independent experiments. (b) Comparison of expression of selected p53 target genes by western blotting analysis.