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Figure 1 | BMC Biology

Figure 1

From: Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity

Figure 1

Structural model for mouse Wnt3a-Fz8 interaction. (A) Overview of the mouse Wnt3a-Fz8-CRD complex. Wnt3a is in grey, Fz8-CRD in blue. The binding sites (site 1, yellow; site 2, red; pseudo site 3, pink) are highlighted and the respective residues marked. Close-up views of binding sites 1 (B) and 2 (C), and pseudo site 3 (D). (E) Alignment of Xenopus Wnt8 and mouse Wnt3a sequences. Mutations introduced into site 1 (yellow), site 2 (red) and site 3 (pink) are indicated.

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BMC Biology

ISSN: 1741-7007

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