Table 1 Active site residue comparison. Comparison of positionally identical active site residues in Vibrio proteolyticus aminopeptidase and human pituitary glutaminyl cyclase. A designation of "none" means the residue plays no discernable role in the enzymatic reaction.
From: Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site
Aminopeptidase Residue | Function in Aminopeptidase | QC residue | Function in QC |
|---|---|---|---|
Asp 117 | Zn bridge | Asp 159 | None |
His 256 | Coordinates Zn #1 | His 330 | Catalytic |
Glu 152 | Coordinates Zn #1 | Glu 202 | Catalytic |
His 97 | Coordinates Zn #2 | His 140 | Catalytic |
Asp 179 | Coordinates Zn #2 | Asp 248 | None |
Glu 151 | Catalytic | Glu 201 | Catalytic |
His 230 | None | His 307 | Substrate binding |
Met 242 | None | His 319 | Substrate binding |