Figure 5 From: Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor Histogram of pramipexole's neuroprotective effects against MPTP induced fiber loss. Effects of subchronic treatment with pramipexole on DAT-IR (A) and TH-IR (B) optical density in the caudate-putamen, nucleus accumbens core and shell of mice treated with or without MPTP. Animals survived for 7 days after the last MPTP injection. Data are mean ± standard error of the mean from 4–5 samples per group. # for P < 0.01, all groups vs SAL + MPTP group; $ for P < 0.01, for SAL-PPX vs SAL-SAL. Abbreviations: CPU, caudate-putamen; Nac Core, nucleus accumbens core; Nac Shell, nucleus accumbens shell; PPX-MPTP, pramipexole + MPTP treated group; SAL-MPTP, saline + MPTP treated group; PPX-SAL, pramipexole + saline treated group; SAL-SAL, saline + saline treated group.Back to article page