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Figure 3 | BMC Biology

Figure 3

From: The functional organization of mitochondrial genomes in human cells

Figure 3

mtDNA associates with tubulin and a kinesin subunit (KIF5B). Cells with YFP-tagged mitochondria were fixed, various targets immunolabelled and imaged in the confocal microscope. (A-D) Four views of one region of the cytoplasm; mtDNA foci are found in mitochondria that are generally aligned with microtubules (mtDNA and tubulin are pseudocoloured green and red in the merge in (D)). Bar: 2 μm. (E-G) Three views of one region of the cytoplasm; mtDNA foci often lie near KIF5B (pseudocoloured red and green in the merge in (G)). Bar: 1 μm. (H) The high Pearson's coefficient (r P ) at Δx values close to zero indicates that mtDNA lies near KIF5B.

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