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Figure 7 | BMC Biology

Figure 7

From: Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm

Figure 7

Model of how starvation and AGE-1 regulate somatic-maintenance gene expression by regulating DAF-16 localisation. Firstly, DAF-16 translocates to the nucleus in response to starvation. In the nucleus DAF-16 activates the transcription of somatic-maintenance genes until an unknown feedback mechanism causes the activation of AGE-1, which results in DAF-16 translocating back to the cytoplasm. This feedback is absent in age-1(hx546) mutants causing increased stress resistance in starved animals or ageing adults.

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BMC Biology

ISSN: 1741-7007

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