Heikki Savolainen, Dept. of Occup. Safety & Hlth., Tampere, Finland
21 May 2007
The authors show that mutations of SDH A are not primarily associated with the tumorigenesis while impairment of its activity leads to serious failures in energy metabolism. They also refer to xenobiotic inhibitors of the SDH complex.
It has been shown that alkoxyacetic acid metabolites from occupational exposure to ethylene glycol ethers, common solvents in water miscible paints, are SDH inhibitors (1, 2) which could explain e.g. oligospermia in ship painters (3) or postulated carcinogenic effects.
1 Laitinen J, Liesivuori J, Turunen H, Savolainen H. 1994. Urinary biochemistry in occupational exposure to glycol ethers. Chemosphere 29: 781-787
2 Liesivuori J, laitinen J, Savolainen H. 1999. Rat model for renal effects of 2-alkoxyalcohols and their acetates. Arch Toxicol 73: 229-232
3 Welch LS, Schrader SM, Turner TW, Cullen MR. 1988. Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction. Am J Ind Med 14: 509-528
Occupational inhibitors of SDH
21 May 2007
The authors show that mutations of SDH A are not primarily associated with the tumorigenesis while impairment of its activity leads to serious failures in energy metabolism. They also refer to xenobiotic inhibitors of the SDH complex.
It has been shown that alkoxyacetic acid metabolites from occupational exposure to ethylene glycol ethers, common solvents in water miscible paints, are SDH inhibitors (1, 2) which could explain e.g. oligospermia in ship painters (3) or postulated carcinogenic effects.
1 Laitinen J, Liesivuori J, Turunen H, Savolainen H. 1994. Urinary biochemistry in occupational exposure to glycol ethers. Chemosphere 29: 781-787
2 Liesivuori J, laitinen J, Savolainen H. 1999. Rat model for renal effects of 2-alkoxyalcohols and their acetates. Arch Toxicol 73: 229-232
3 Welch LS, Schrader SM, Turner TW, Cullen MR. 1988. Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction. Am J Ind Med 14: 509-528
Competing interests
None