Figure 1

Literature-based gene regulatory network describing proneural bHLH regulation of telencephalon neurogenesis. Activations are identified with an arrow and repressions are identified with a barred line. Those connections that are significant based on the current microarray dataset are shown in red. Significant relationships were determined through analysis of the distribution of the strength of linkage parameter (β) after 500,000 MCMC simulations (Additional file 6). If more than 95% of the simulations have values above zero they are considered significant. A * denotes connections that were significant, but as inhibition.