Figure 9
Impact of copper on oxidative phosphorylation and on glycolysis/gluconeogenesis. Human orthologues of transcripts exhibiting more than twofold alterations in their transcript level upon copper exposure were mapped onto the KEGG pathways [92] representing (A) oxidative phosphorylation (adapted from KEGG ID: hsa00190) and (B) glycolysis/gluconeogenesis (adapted from KEGG ID: hsa00010). Transcripts with more than twofold alterations are outlined in red, and those with less than twofold alterations are outlined in blue. Transcripts that are not outlined were not present in the gene set used for the cDNA microarrays. (C) The transcript levels on a log10 scale for the genes marked in (A). For genes represented by more than one transcript (multiple ESTs), mean values are shown. The black dotted line indicates no gene induction. (D) The transcript levels for the genes marked in (B) (red lines); phosphoenolpyruvate carboxykinase is also represented (blue line), although it is not shown in (B).