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Figure 2 | BMC Biology

Figure 2

From: A comprehensive functional analysis of tissue specificity of human gene expression

Figure 2

Top-scored pathways maps and process networks for housekeeping proteins. (I) Oxidative phosphorylation map. The subunits of the complexes are grouped in blue boxes; the red 'thermometer' histograms mark housekeeping (HK) genes. (II) Network for ubiquitin-mediated protein degradation in proteosome. HK genes are marked with solid red circles. The most important network components functionally, identified as HK genes, are marked with circles: ubiquitins and small ubiquitin-like modifiers (Ubiquitin, Ubiquitin C, Sumo-1, Sumo-2 are encircled in red); the ubiquitin-activating enzyme (UBE1 is encircled in black); ubiquitin-conjugating enzymes (UBCH8, UBE2D2, UBE2D3, UBC13, UBCH7 are encircled in blue); proteins that may act as ubiquitin protein ligases E3 (DTX2, DTX3, Rnf14, Rnf103 are encircled in green); the chaperons (HSP70 and HSP90 encircled in orange) and proteasomal subunits (26S proteasome, 26S proteasome, immunoproteasome (11S regulator) are encircled in brown). (III) Network for the GeneGo process translation initiation. HK genes are marked with solid red circles and translation initiation factors are encircled in red.

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