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Table 1 Comparison of the gene structures of mouse and human nonsense-mediated mRNA decay and non-nonsense-mediated mRNA decay candidates

From: Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

 

Human

Mouse

 

NMD

Non-NMD

P

NMD

Non-NMD

P

Average intron length

3,001

2,641.2

1.1 × 10-3

2,399.1

1,957.1

2.1 × 10-5

5' UTR length

145

132

8.4 × 10-4

124

102

7.0 × 10-6

3' UTR length

1,049

618

2.9 × 10-28

1134

513

4.4 × 10-47

Protein length

341

420

5.6 × 10-12

337

378

1.6 × 10-6

Total number of genes

701

17,498

 

498

17,479

 
  1. Notes. NMD = Nonsense-mediated mRNA decay. NMD: NMD candidates; Non-NMD: genes that are not NMD candidates. The median values for each parameter are listed because the mean values were not suitable for highly skewed distributions. The P value was determined using the Wilcoxon rank-sum (Mann-Whitney) test.
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BMC Biology

ISSN: 1741-7007

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