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Table 1 Comparison of the gene structures of mouse and human nonsense-mediated mRNA decay and non-nonsense-mediated mRNA decay candidates

From: Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

  Human Mouse
  NMD Non-NMD P NMD Non-NMD P
Average intron length 3,001 2,641.2 1.1 × 10-3 2,399.1 1,957.1 2.1 × 10-5
5' UTR length 145 132 8.4 × 10-4 124 102 7.0 × 10-6
3' UTR length 1,049 618 2.9 × 10-28 1134 513 4.4 × 10-47
Protein length 341 420 5.6 × 10-12 337 378 1.6 × 10-6
Total number of genes 701 17,498   498 17,479  
  1. Notes. NMD = Nonsense-mediated mRNA decay. NMD: NMD candidates; Non-NMD: genes that are not NMD candidates. The median values for each parameter are listed because the mean values were not suitable for highly skewed distributions. The P value was determined using the Wilcoxon rank-sum (Mann-Whitney) test.