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Table 4 Comparison of exon creation/loss between human nonsense-mediated mRNA decay-specific and non nonsense-mediated mRNA decay-single exons

From: Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

Evolutionary patterns Human (source) Mouse (target) Dog (outgroup) NMD-specific NonNMD-single
Conserved in target + + + 23 436
Conserved in target + + - 1 13
Lost in target + - + 2 38
Created in source + - - 9 66
Total     35 553
  1. Notes. NMD = nonsense-mediated mRNA decay. +, The orthologous exon exists in this lineage; -, The orthologous exon is not observed in this lineage.