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Table 1 Differentially expressed genes in AP-2α low-expressing GN-11 clones

From: AP-2α regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase

Gene Description Accession number FC
Cell cycle    
Ccnd1 cyclin D1 (Ccnd1), mRNA. NM_007631 -3.0
Cetn3 centrin 3 (Cetn3), mRNA. NM_007684 -2.7
Cdc2a cell division cycle 2 homolog A (S. pombe) NM_007659 -2.4
Cdkn2a cyclin-dependent kinase inhibitor 2A (Cdkn2a), mRNA. NM_009877 -2.4
Skp2 S-phase kinase-associated protein 2 (p45) NM_013787 -2.2
Kras2 Kirsten rat sarcoma oncogene 2, expressed (Kras2), mRNA. NM_021284 -2.1
Pa2g4 proliferation-associated 2G4 (Pa2g4), mRNA. NM_011119 2.2
Stmn1 stathmin 1 (Stmn1), mRNA. NM_019641 2.3
Tgif TG interacting factor (Tgif), mRNA. NM_009372 2.4
Anapc1 anaphase promoting complex subunit 1 (Anapc1), mRNA. NM_008569 2.5
Atf5 activating transcription factor 5 (Atf5), mRNA. NM_030693 2.5
Cdk5rap3 CDK5 regulatory subunit associated protein 3 (Cdk5rap3), mRNA. NM_030248 2.8
Apoptosis    
Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a (Tnfrsf12a), mRNA. NM_013749 -2.8
Ngfrap1 nerve growth factor receptor (TNFRSF16) associated protein 1 (Ngfrap1), mRNA. NM_009750 -2.7
Ppm1f protein phosphatase 1F (PP2C domain containing) (Ppm1f), mRNA. NM_176833 -2.7
Gpx1 glutathione peroxidase 1 (Gpx1), mRNA. NM_008160 -2.7
Siva Cd27 binding protein (Hindu God of destruction) (Siva), mRNA. NM_013929 -2.6
Birc5 baculoviral IAP repeat-containing 5 (Birc5), mRNA. NM_009689 -2.6
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha (Prkar1a), mRNA. NM_021880 -2.5
Cycs cytochrome c, somatic (Cycs), mRNA. NM_007808 -2.5
Syvn1 synovial apoptosis inhibitor 1, NM_028769 2.5
Sqstm1 sequestosome 1 (Sqstm1), mRNA. NM_011018 2.9
Development    
Emp1 epithelial membrane protein 1 (Emp1), mRNA. NM_010128 -3.0
Csrp2 cysteine and glycine-rich protein 2 (Csrp2), mRNA. NM_007792 -2.6
Crip2 cysteine rich protein 2 (Crip2), mRNA. NM_024223 2.5
ECM/cell adhesion    
Lox lysyl oxidase (Lox), mRNA. NM_010728 -3.4
Timp1 tissue inhibitor of metalloproteinase 1 (Timp1), mRNA. NM_011593 -3.2
Timp2 tissue inhibitor of metalloproteinase 2 (Timp2), mRNA. NM_011594 -3.0
Col6a1 procollagen, type VI, alpha 1 (Col6a1), mRNA. NM_009933 -2.8
Col5a1 procollagen, type V, alpha 1 (Col5a1), mRNA. NM_015734 -2.5
Mmp2 matrix metalloproteinase 2 (Mmp2), mRNA. NM_008610 -2.0
Ptprs protein tyrosine phosphatase, receptor type, S (Ptprs), mRNA. NM_011218 2.5
Mfge8 milk fat globule-EGF factor 8 protein (Mfge8), mRNA. NM_008594 2.6
Cell migration    
Ryk receptor-like tyrosine kinase (Ryk), mRNA. NM_013649 -2.7
Rtn4 reticulon 4 (Rtn4), transcript variant 5, mRNA. NM_194054 -2.7
Axl AXL receptor tyrosine kinase (Axl), mRNA. NM_009465 -2.6
Wisp1 WNT1 inducible signaling pathway protein 1 (Wisp1), mRNA. NM_018865 -2.5
Ccl7 chemokine (C-C motif) ligand 7 NM_013654 -2.4
Cyb5 cytochrome b-5 (Cyb5), mRNA NM_025797 -2.3
Nup62 nucleoporin 62 (Nup62), mRNA. NM_053074 2.3
Others    
Anxa5 annexin A5 (Anxa5), mRNA. NM_009673 -3.0
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (yeast) NM_009460 -3.0
Sms spermine synthase (Sms), mRNA. NM_009214 -3.0
Cenpa centromere autoantigen A (Cenpa), mRNA. NM_007681 -2.9
Plec1 plectin 1 (Plec1), transcript variant 1, mRNA. NM_011117 -2.9
Lmna lamin A (Lmna), mRNA. NM_019390 -2.9
Nedd8 neural precursor cell expressed, developmentally down-regulated gene 8 (Nedd8), mRNA. NM_008683 -2.8
Pfdn5 prefoldin 5 (Pfdn5), mRNA. NM_020031 -2.7
Rab2 RAB2, member RAS oncogene family (Rab2), mRNA. NM_021518 -2.7
Fscn1 fascin homolog 1, actin bundling protein (Strongylocentrotus) purpuratus) (Fscn1), mRNA. NM_007984 -2.6
Serpinb6a serine (or cysteine) proteinase inhibitor, clade B, member 6a (Serpinb6a), mRNA. NM_009254 -2.6
S100a1 S100 calcium binding protein A1 (S100a1), mRNA. NM_011309 -2.5
Timm8a translocase of inner mitochondrial membrane 8 homolog a (yeast) NM_013898 -2.3
Ppap2a phosphatidic acid phosphatase 2a (Ppap2a), mRNA. NM_008903 -2.2
Fez2 fasciculation and elongation protein zeta 2 (zygin II) NM_199448 -2.0
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) (Ankrd1), mRNA. NM_013468 1.7
Pole polymerase (DNA directed), epsilon (Pole), mRNA. NM_011132 1.9
Naglu alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) (Naglu), mRNA. NM_013792 2.0
Ruvbl2 RuvB-like protein 2 (Ruvbl2), mRNA. NM_011304 2.0
Gig1 glucocorticoid induced gene 1 (Gig1), mRNA. NM_133218 2.1
Soat1 sterol O-acyltransferase 1 (Soat1), mRNA. NM_009230 2.1
Ris2 retroviral integration site 2 (Ris2), mRNA. NM_026014 2.8
Ier3 immediate early response 3 (Ier3), mRNA. NM_133662 2.8
  1. Microarray analysis (Illumina Ref-8 BeadChip) was performed on GN-11 pSUPER-empty and AP-2α-low-expressing (α4-c) clones in duplicate and 510 modulated genes were found (305 decreased, 205 increased, see Methods). A selection of the most interesting modulated genes is shown. FC = Fold change.