Mutations in many genes affect aggressive behavior in Drosophila melanogaster

Edwards, Alexis C; Zwarts, Liesbeth; Yamamoto, Akihiko; Callaerts, Patrick; Mackay, Trudy FC

doi:10.1186/1741-7007-7-29

Table 1 P{GT1} lines with aberrant aggressive behavior

From: Mutations in many genes affect aggressive behavior in Drosophila melanogaster

P-element line	Disrupted locus	Cytogenetic location	Mutational effects		Pleiotropic effects					Gene ontology
			MAS	*a/σ* _P	B	L	O	Sl	St
BG00151	CG9894	23A3–23A3	16.35**	0.96						Unknown
BG00336	Guanine nucleotide exchange factor GEF64C	64B13–64B17	6.1***	-1.45					↓	Axon guidance; regulation of Rho protein signal transduction
BG00372	CG1678	20A1-20A1	17.2***	0.94				↑		Unknown
BG00375	Odorant-binding protein 99d	99B8-99B8	14.8**	0.53	↑				↓	Odorant binding; autophagic cell death; transport
BG00376†	CG3638	1E4-1E4	18.45***	1.16	↑			↑	↓	Unknown
BG00386	NMDA receptor 1	83A6–83A7	20.65***	1.53					↓	Long-term memory; olfactory learning; calcium-mediated signaling; nerve-nerve synaptic transmission; nervous system development
BG00670	CG32541	17F3-18A2	13.35**	0.28	↑					Unknown
BG00735	schizo	78A5-78B1	16.25***	0.78					↑	Central nervous system development; guanyl-nucleotide exchange factor activity
BG00986†	extra macrochaetae	61C9-61C9	7.05***	-0.90	↑	↓		↑	↓	Nervous system development
BG01011	Spinophilin	62E4–62E5	17.2***	0.69		↓		↑	↑	Phosphopantetheine binding
BG01043	Gp150	58D3-58D3	18.0*	0.91						ATP binding; transmembrane receptor protein tyrosine phosphatase signaling pathway
BG01046	CG3587	2B16-2B16	7.9***	-0.60	↑	↓			↓	Unknown
BG01130	alan shepard	64C8–64C11	16.55***	0.86				↑	↓	mRNA processing; gravitaxis
BG01214†	sugarless	65D4–65D5	17.1***	0.93				↑	↓	Cell communication; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
BG01215	CG11299	59F6–59F7	8.7**	-0.48	↑	↓			↓	Regulation of progression through cell cycle; cell cycle arrest
BG01299†	Actin 5C	5C7-5C7	3.6***	-1.75	↓	↓				structural constituent of cytoskeleton; ATP binding; protein binding
BG01354	CG30492	43E5–43E7	18.55**	1.01	↑					Zinc ion binding
BG01402	CG32345	61C7-61C7	15.55***	0.68		↓			↓	Unknown
BG01433	CG13791	28B1–28B2	16.75**	0.60		↓			↓	Unknown
BG01469†	Syntaxin 4	3B4-3B4	7.9***	-0.65		↓			↓	t-SNARE activity; neurotransmitter secretion; vesicle-mediated transport; synaptic vesicle docking during exocytosis
BG01491	tramtrack	100D1-100D1	14.45*	0.48	↑				↓	Zinc ion binding; peripheral nervous system development; transmission of nerve impulse
BG01498	Casein kinase Iα	11B7-11B7	8.85*	-0.43	↑				↓	Receptor signaling protein serine/threonine kinase activity; ATP binding
BG01536	Beadex	17C3–17C4	7.25***	-0.60	↑	↓			↓	Zinc ion binding; locomotory behavior; response to cocaine; regulation of metabolism
BG01566	arrest	33D3–33D5	6.75***	-0.75						Negative regulation of oskar mRNA translation
BG01596†	CG13377	1A1-1A1	19.55***	1.74		↓	↑	↑	↓	Metabolism
BG01654	pickpocket 23	16B4-16B4	9.55**	-0.57		↓			↑	Sodium channel activity
BG01662	Laminin A	65A8–65A9	15.55**	0.68				↑	↓	Receptor binding; locomotion; central nervous system development
BG01683†	CG32572	15A3-15A3	7.65***	-0.66		↓			↓	Unknown
BG01693	CG10777	7C3–7C4	4.5***	-1.11		↓	↑		↓	RNA helicase activity; nucleic acid binding; ATP binding; ATP-dependent helicase activity
BG01713	4EHP	95E1-95E1	8.9**	-0.50		↓				Translation initiation
BG01733	CG6175	68C1–68C2	14.55*	0.51	↑	↓			↓	Unknown
BG01757	CG17323	37B1-37B1	12.75*	0.50		↓				Defense response; polysaccharide metabolism; response to toxin; steroid metabolism
BG01765	Tehao	34C1-34C1	8.35**	-0.70	↓					Transmembrane receptor activity; signal transduction; Toll signaling pathway
BG01893	Splicing factor 1	90B4-90B4	7.2*	-0.51	↑	↓			↓	Transcription cofactor activity; nucleic acid binding; zinc ion binding
BG01900	mir-317	85F10-85F10	6.6**	-0.62	↑	↓			↓	microRNA
BG01909	CG14035	25C6-25C6	21.45***	2.27	↓	↓	↑		↓	Unknown
BG01912†	pxb	89A1–89A2	17.3***	0.85	↑	↓				Learning and/or memory; olfactory learning
BG01916	no ocelli	35B2-35B2	13.65**	0.36				↑	↓	Zinc ion binding
BG01949	ade5	11B16–11B16	16.2*	0.57					↓	Purine base metabolism; 'de novo' IMP biosynthesis
BG02019	CG9171	25F4–25F5	13.3**	0.60						Transferase activity
BG02022	CG34460	2R	7.15***	-0.91		↓	↑			Unknown
BG02077	Rtnl1	25B9-25C1	9.0*	-0.65	↑			↓	↓	Receptor signaling protein activity; calcium ion binding
BG02081	Rtnl1	25B9-25C1	16.6***	1.19		↓	↑			Receptor signaling protein activity; calcium ion binding
BG02095†	echinoid	24D4–24D6	14.8**	0.68					↑	Epidermal growth factor receptor signaling pathway; negative regulation of neurogenesis; sensory organ development
BG02128	lethal (1) G0007	12E3–12E5	5.55***	-0.86		↓			↓	ATP-dependent RNA helicase activity; ATP-dependent helicase activity; ATP binding
BG02188	eclair	85E4-85E4	15.8***	0.56	↑					Intracellular protein transport
BG02217	plexus	58E4–58E8	4.6***	-0.99	↓	↓				Wing vein morphogenesis
BG02276	lethal (3) L1231	88C10-88C10	10.95*	0.44	↑					Unknown
BG02377	CG14478	54B16-54B16	4.2**	-0.56	↓/↑					Unknown
BG02420	CG5946	68E1-68E1	3.85**	-0.61	↑					Cholesterol metabolism; electron transport; fatty acid desaturation
BG02470	CG8963	53E4-53E4	7.6*	-0.52	↓	↓	↑			Unknown
BG02495	ade5	11B16-11B16	13.35*	0.33				↑	↓	Purine base metabolism; 'de novo' IMP biosynthesis
BG02501	longitudinals lacking	47A11–47A13	7.9*	-0.61	↑					Axon guidance; axonogenesis; transmission of nerve impulse
BG02522	CG42270	16C1–16C8	6.1***	-0.80		↓	↑			Ras GTPase activator activity; receptor binding; G-protein coupled receptor protein signaling pathway;
BG02523	lamina ancestor	64C12–64C13	7.95***	-0.59	↑					Unknown
BG02539	Basigin	28E3–28E5	15.5**	-0.58				↑	↓	Spermatid development
BG02542	neuralized	85C2–85C3	11.35*	-0.60	↑					Ubiquitin-protein ligase activity; protein binding; zinc ion binding; nervous system development; sensory organ development; regulation of Notch signaling pathway
BG02644	Fkbp13	57E6-57E6	12.0**	0.59	↑					Calcium ion binding; protein folding
BG02731	longitudinals lacking	47A11–47A13	13.6**	0.63	↓					Axon guidance; axonogenesis; Transmission of nerve impulse

MAS = Mean Aggression Score. Significant MAS deviations from the control line after correcting for multiple tests are indicated by asterisks. *: P < 0.05; **: P < 0.01; ***: P < 0.0001. † Indicates lines characterized in greater detail. Pleiotropic effects of the mutations are given for numbers of sensory bristles (B) [30], locomotor startle response (L) [34]; olfactory avoidance behavior (O) [33]; male 24-hour sleep (Sl) [32] and male starvation stress resistance (St) [31]. The arrows indicate significant positive (↑) and negative (↓) deviations from the control.

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ISSN: 1741-7007

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