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Table 1 P{GT1} lines with aberrant aggressive behavior

From: Mutations in many genes affect aggressive behavior in Drosophila melanogaster

P-element line Disrupted locus Cytogenetic location Mutational effects Pleiotropic effects Gene ontology
    MAS a/σ P B L O Sl St  
BG00151 CG9894 23A3–23A3 16.35** 0.96       Unknown
BG00336 Guanine nucleotide exchange factor GEF64C 64B13–64B17 6.1*** -1.45      Axon guidance; regulation of Rho protein signal transduction
BG00372 CG1678 20A1-20A1 17.2*** 0.94      Unknown
BG00375 Odorant-binding protein 99d 99B8-99B8 14.8** 0.53     Odorant binding; autophagic cell death; transport
BG00376† CG3638 1E4-1E4 18.45*** 1.16    Unknown
BG00386 NMDA receptor 1 83A6–83A7 20.65*** 1.53      Long-term memory; olfactory learning; calcium-mediated signaling; nerve-nerve synaptic transmission; nervous system development
BG00670 CG32541 17F3-18A2 13.35** 0.28      Unknown
BG00735 schizo 78A5-78B1 16.25*** 0.78      Central nervous system development; guanyl-nucleotide exchange factor activity
BG00986† extra macrochaetae 61C9-61C9 7.05*** -0.90   Nervous system development
BG01011 Spinophilin 62E4–62E5 17.2*** 0.69    Phosphopantetheine binding
BG01043 Gp150 58D3-58D3 18.0* 0.91       ATP binding; transmembrane receptor protein tyrosine phosphatase signaling pathway
BG01046 CG3587 2B16-2B16 7.9*** -0.60    Unknown
BG01130 alan shepard 64C8–64C11 16.55*** 0.86     mRNA processing; gravitaxis
BG01214† sugarless 65D4–65D5 17.1*** 0.93     Cell communication; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
BG01215 CG11299 59F6–59F7 8.7** -0.48    Regulation of progression through cell cycle; cell cycle arrest
BG01299† Actin 5C 5C7-5C7 3.6*** -1.75     structural constituent of cytoskeleton; ATP binding; protein binding
BG01354 CG30492 43E5–43E7 18.55** 1.01      Zinc ion binding
BG01402 CG32345 61C7-61C7 15.55*** 0.68     Unknown
BG01433 CG13791 28B1–28B2 16.75** 0.60     Unknown
BG01469† Syntaxin 4 3B4-3B4 7.9*** -0.65     t-SNARE activity; neurotransmitter secretion; vesicle-mediated transport; synaptic vesicle docking during exocytosis
BG01491 tramtrack 100D1-100D1 14.45* 0.48     Zinc ion binding; peripheral nervous system development; transmission of nerve impulse
BG01498 Casein kinase Iα 11B7-11B7 8.85* -0.43     Receptor signaling protein serine/threonine kinase activity; ATP binding
BG01536 Beadex 17C3–17C4 7.25*** -0.60    Zinc ion binding; locomotory behavior; response to cocaine; regulation of metabolism
BG01566 arrest 33D3–33D5 6.75*** -0.75       Negative regulation of oskar mRNA translation
BG01596† CG13377 1A1-1A1 19.55*** 1.74   Metabolism
BG01654 pickpocket 23 16B4-16B4 9.55** -0.57     Sodium channel activity
BG01662 Laminin A 65A8–65A9 15.55** 0.68     Receptor binding; locomotion; central nervous system development
BG01683† CG32572 15A3-15A3 7.65*** -0.66     Unknown
BG01693 CG10777 7C3–7C4 4.5*** -1.11    RNA helicase activity; nucleic acid binding; ATP binding; ATP-dependent helicase activity
BG01713 4EHP 95E1-95E1 8.9** -0.50      Translation initiation
BG01733 CG6175 68C1–68C2 14.55* 0.51    Unknown
BG01757 CG17323 37B1-37B1 12.75* 0.50      Defense response; polysaccharide metabolism; response to toxin; steroid metabolism
BG01765 Tehao 34C1-34C1 8.35** -0.70      Transmembrane receptor activity; signal transduction; Toll signaling pathway
BG01893 Splicing factor 1 90B4-90B4 7.2* -0.51    Transcription cofactor activity; nucleic acid binding; zinc ion binding
BG01900 mir-317 85F10-85F10 6.6** -0.62    microRNA
BG01909 CG14035 25C6-25C6 21.45*** 2.27   Unknown
BG01912† pxb 89A1–89A2 17.3*** 0.85     Learning and/or memory; olfactory learning
BG01916 no ocelli 35B2-35B2 13.65** 0.36     Zinc ion binding
BG01949 ade5 11B16–11B16 16.2* 0.57      Purine base metabolism; 'de novo' IMP biosynthesis
BG02019 CG9171 25F4–25F5 13.3** 0.60       Transferase activity
BG02022 CG34460 2R 7.15*** -0.91     Unknown
BG02077 Rtnl1 25B9-25C1 9.0* -0.65    Receptor signaling protein activity; calcium ion binding
BG02081 Rtnl1 25B9-25C1 16.6*** 1.19     Receptor signaling protein activity; calcium ion binding
BG02095† echinoid 24D4–24D6 14.8** 0.68      Epidermal growth factor receptor signaling pathway; negative regulation of neurogenesis; sensory organ development
BG02128 lethal (1) G0007 12E3–12E5 5.55*** -0.86     ATP-dependent RNA helicase activity; ATP-dependent helicase activity; ATP binding
BG02188 eclair 85E4-85E4 15.8*** 0.56      Intracellular protein transport
BG02217 plexus 58E4–58E8 4.6*** -0.99     Wing vein morphogenesis
BG02276 lethal (3) L1231 88C10-88C10 10.95* 0.44      Unknown
BG02377 CG14478 54B16-54B16 4.2** -0.56 ↓/↑      Unknown
BG02420 CG5946 68E1-68E1 3.85** -0.61      Cholesterol metabolism; electron transport; fatty acid desaturation
BG02470 CG8963 53E4-53E4 7.6* -0.52    Unknown
BG02495 ade5 11B16-11B16 13.35* 0.33     Purine base metabolism; 'de novo' IMP biosynthesis
BG02501 longitudinals lacking 47A11–47A13 7.9* -0.61      Axon guidance; axonogenesis; transmission of nerve impulse
BG02522 CG42270 16C1–16C8 6.1*** -0.80     Ras GTPase activator activity; receptor binding; G-protein coupled receptor protein signaling pathway;
BG02523 lamina ancestor 64C12–64C13 7.95*** -0.59      Unknown
BG02539 Basigin 28E3–28E5 15.5** -0.58     Spermatid development
BG02542 neuralized 85C2–85C3 11.35* -0.60      Ubiquitin-protein ligase activity; protein binding; zinc ion binding; nervous system development; sensory organ development; regulation of Notch signaling pathway
BG02644 Fkbp13 57E6-57E6 12.0** 0.59      Calcium ion binding; protein folding
BG02731 longitudinals lacking 47A11–47A13 13.6** 0.63      Axon guidance; axonogenesis; Transmission of nerve impulse
  1. MAS = Mean Aggression Score. Significant MAS deviations from the control line after correcting for multiple tests are indicated by asterisks. *: P < 0.05; **: P < 0.01; ***: P < 0.0001. † Indicates lines characterized in greater detail. Pleiotropic effects of the mutations are given for numbers of sensory bristles (B) [30], locomotor startle response (L) [34]; olfactory avoidance behavior (O) [33]; male 24-hour sleep (Sl) [32] and male starvation stress resistance (St) [31]. The arrows indicate significant positive (↑) and negative (↓) deviations from the control.