Table 1 Characteristic kinetic constants for the hydrolysis of ATCh and BTCh by DmAChE, HuAChE and HuBChE

Substrate

k ₃ [s^-1]

395.4

13471 ± 2171

1082 ± 44

K _ip [mM]

0.17

5.43 ± 1.0

11.3 ± 0.5

K _L

4.17

0.0181 ± 0.0054

0.0019 ± 0.0008

K _LL

179

9.23 ± 6.58

12.3 ± 5.4

k ₂ [s^-1]

53465

14375 ± 2182

420 ± 20

A

3.44

1.64 ± 0.36

1.32 ± 0.07

B

0.049

0.11 ± 0.03

39.6 ± 13.5

K _s = K _p *K _L [mM]

0.73

0.098

0.021

K _ss = K _p *K _LL [mM]

31.1

50.1

139

DEET

K _ip [mM]

1.02 ± 0.03

8.39 ± 6.97

0.37 ± 0.05

K _iL

0.083 ± 0.078

1.54 ± 0.45

K _iLL

0.56 ± -0.41

29 ± 5.4

c

1.49 ± 0.99

1.32

d

0.19 ± 0.18

0.52 ± 0.09

K _is = K _ip *K _iL [mM]

0.69

0.57

K _iss = K _ip *K _iLL [mM]

4.67

1.08