Figure 4

finTRIMs represent a teleost-specific multigenic family. (A). Multiple alignment of representative teleost finTRIM protein sequences. Rainbow trout (onmy) [GenBank:AM887799], zebrafish (dare) (ftr14, [GenBank:XM_692536]), channel catfish (icpu) ([GenBank:BM424798], medaka (orla) (Ensembl: ENSORLP00000003320), Stickleback (gaac) (Ensembl, Linkage group III: 14324861–14326501; GENSCAN00000022585), Pufferfish (teni) (Ensembl GSTENT00020235001). (B and C) Phylogenetic trees (NJ, boostrap = 1000) of the finTRIM and their relatives, based on the RBB (B) and B30.2 (C) regions. finTRIM accession numbers are as in (A); other sequences from zebrafish: Bty (bloodthirsty) [GenBank: NP_001018311]; TRIM25, [GenBank: NP_956469]; TRIM16, [GenBank: XR_029737]; from human: TRIM16, [SwissProt: Q99PP9]; TRIM25, [SwissProt: Q14258]; TRIM39, [GenBank: NP_742013]; from chicken: TRIM25, [GenBank: XP_415653]; from salmon: TRIM25 [gene index TC35355 accessible at http://compbio.dfci.harvard.edu/]; from xenopus: TRIM16a, [GenBank: AAH74300]; TRIM16b, [GenBank: NP_001086184]; TRIM25, [Ensembl Xenopus genome scaffold255: 821309_819660]; TRIM39, [Ensembl Xenopus genome scaffold709: 241758_272825].