Genetical genomic determinants of alcohol consumption in rats and humans

Table 3 Genetic (SNP) Associations with Alcohol Consumption: WHO/ISBRA Subjects

refSNP ID	Location Within Gene	Chr	Basepair	minor allele/major allele ^a	MAF (Males/Females)	unadjusted p-value	FDR
MONTREAL
rs2241165	intronic region of GAD1	2	171386625	C/T	0.25/0.23	0.0001	0.0400
rs701492	intronic or downstream region of GAD1	2	171410726	T/C	0.31/0.31	<0.0001	0.0018
rs7578661	intronic region of GAD1	2	171423379	G/C	0.31/0.31	<0.0001	0.0018
rs1389752	intronic region of MPDZ	9	13225287	A/T	0.14/0.15	<0.0001^b	0.0130^b
SYDNEY
rs8030094	intronic region of CHRM5	15	32124174	A/G	0.18/NA	0.0002	0.0326
rs10051667	intronic region of GABRB2	5	160830906	C/T	0.09/NA	<0.0001	0.0110
rs9607272	intronic region of MAPK1 and TUBA8^c	22	20466398	G/T	0.19/NA	<0.0001	0.0062
rs879606	upstream region of PPP1R1B	17	35035375	A/G	0.13/NA	<0.0001	0.0062

Significant results from univariate association analysis with alcohol consumption. Shown are the eight SNPs that showed a significant (FDR<0.05) association with alcohol consumption (g/kg/day) in a genotype model.
^aMinor and major allele designation is according to Ensembl release 50.
^bThis SNP was significant when both genders are combined; in male subjects, the FDR for this SNP was 0.09. All other SNPs shown were significant when males only were tested.
^cThe localization of this SNP is ambiguous. Its presence in MAPK1 and the overlapping gene, TUBA8 (tubulin alpha 8) is of particular interest, given the findings of differences in expression of cytoskeletal genes in the HXB/BXH rat strains.

ISSN: 1741-7007