The metabolic signature of long-life. A. Relative concentrations of 26 metabolites in worms sampled at 25°C and 240 hours post-hatching. B. Summary of metabolic responses. Here we show, for all experiments, the observed response in long-lived worms relative to appropriate controls and rank them by their consistency; p values for individual experiment are given in each cell: * P < 0.05; ** <0.01; *** <0.001; **** <0.0001. For all data and statistics see Additional file 1.