Skip to main content

Table 4 Pfam domains overrepresented in gene duplications associated with 2Ra

From: 2R and remodeling of vertebrate signal transduction engine

Domain name Pfam ID Pvalue
PH domain PF00169 8.85e-23
Homeobox domain PF00046 5.42e-12
7 transmembrane receptor (rhodopsin family) PF00001 1.17e-11
Tyrosine kinase domain PF07714 1.84e-10
Serine/threonine kinase domain PF00069 3.18e-10
PDZ PF00595 4.30e-10
Intermediate filament protein PF00038 1.02e-09
EGF-like domain PF00008 3.39e-08
EF hand PF00036 5.20e-08
Helix-loop-helix DNA-binding domain PF00010 8.32e-08
SH3 domain PF00018 8.80e-08
Ras family PF00071 9.14e-08
Ion transport protein PF00520 1.27e-07
SH2 domain PF00017 1.30e-07
C2 domain PF00168 4.48e-07
Neurotransmitter-gated ion channel ligand binding domain PF02931 7.02e-07
Neurotransmitter-gated ion channel transmembrane region PF02932 7.02e-07
Protein tyrosine phosphatase PF00102 1.24e-06
RhoGEF domain PF00621 1.24e-06
Calponin homology (CH) domain PF00307 2.32e-06
7 transmembrane receptor (Secretin family) PF00002 3.11e-06
SAM domain (Sterile α motif) PF00536 3.11e-06
Protein kinase C terminal domain PF00433 5.10e-06
Hormone receptor domain PF02793 5.68e-06
RhoGAP domain PF00620 6.71e-06
Fibronectin type III domain PF00041 7.08e-06
IPT/TIG domain PF01833 9.61e-06
Ligand-binding domain of nuclear PF00104 1.84e-05
hormone receptor   
Phosphotyrosine interaction domain (PTB/PID) PF00640 2.75e-05
Phorbol esters/diacylglycerol binding domain (C1 domain) PF00130 2.84e-05
Laminin G domain PF02210 3.63e-05
E1-E2 ATPase PF00122 7.87e-05
  1. aAll Pfam domains overrepresented in gene duplications associated with 2ROs at the Pvalue cutoff of 0.0001 can be linked with signal transduction. Pvalues derive from the hypergeometric test. EGF, epidermal growth factor; PH domain, pleckstrin homology domain (PH domain); SH3, Src homology 3; SH2, Src homology 2; ig-like, plexins, transcription factors (IPT/TIG); phosphotyrosine-binding domain/phosphotyrosine interaction domain (PTB/PID).