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Figure 2 | BMC Biology

Figure 2

From: Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells

Figure 2

Chronic mild folate depletion affects prostate cells' phenotype. (A) Anchorage-independent colonies in soft agar. 10,000 cells well were seeded in semi-solid agar and allowed to grow for 4 weeks. Data presented is the average and SD of six replicates. (B) Folate dependent growth rates. Growth rates (average and standard deviation) are calculated normalizing to growth in control amounts of folate (2 μM) set as 100%. (C) High-performance liquid chromatography analysis of polyamine pools. Results are the average and standard deviation of two biologically independent samples. Values are normalized to those obtained in GCtrl cells, set as 100%. * = P < 0.05, ** = P < 0.01, *** = P < 0.001.

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BMC Biology

ISSN: 1741-7007

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