Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

Table 3 Motif relationships in nitrile hydratase leader peptide (NHLP) and Nif11-related protein (N11P) leader sequences to nitrile hydratase (NHase)

Accession	Description	Motif 1	Motif 2	Leader	Suffix
TIGR01847	Gram-positive leader	N/A	ELSEKELAQIIGG	23	41
TIGR03898	lichenicidin leader	IIRAWKDPEYRASLSSE	ELSDEELESITGG	47	30
TIGR03798	N11P	N/A	ELSDEELEAVAGG	69	23
TIGR03793	NHLP	IKKAWSDEEFKQALLNN	ELSDEQLDAVAGG	87	27
TIGR03795	NHLP-Burk	IALAWHDPEFRDELLAD	N/A	108	11
TIGR01323	NHase	VAKAWVDPEFKARLLKD	GLSEEQLAALVTR	193	16

Sequence similarities and motif positions in NHase alpha subunit and putative leader sequences. Residues shared by at least 70% of the calculated consensus sequences are shown in boldface. Leader peptide length is taken as the position of the C-terminal end of motif 2, averaged after the shortest 10% and longest 10% removed of each family are removed as outliers and possible gene call errors. The similarity of NHLP to N11P in motif 2 suggests intragenic recombination.

ISSN: 1741-7007