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Table 1 Published studies analyzing parental strains using the QTL/Microarray approach in rat

From: Serious limitations of the QTL/Microarray approach for QTL gene discovery

  Phenotype QTL Mapping Microarray Experiment References
   Design Strains Design Tissues Platform  
  Targeted custom arrays
  Hypertension Congenic DS, LEW Congenic Kidney Custom/
TIGR
[43]
  Hypertension F2 DS, LEW Parental Kidney RT-PCR [31]
  Whole-Genome arrays       
Aerobic running capacity Congenic DS, DR Parental Kidney RGU34 [34, 95, 96]
  Alcohol addiction Congenic iP, iNP Congenic NAC, FC, ABR, hippocampus, striatum RG230v2 [97]
  Hypertension F2 SBH/y, SBN/y Parental Kidney RAE230 [41, 98]
Hypertension Congenic DS, LEW Congenic Kidney RGU34 [30]
Hypertension Congenic DS, DR Congenic Kidney RGU34 [42, 99]
Hypertension Congenic SHRSP, WKY Congenic Kidney RGU34 [44]
  Hypertension F2 DS, LEW Parental Kidney RAE230 [32]
  Hypertension F2 DS, LEW Parental Kidney, adrenal gland, liver, brain RG230v2 [33]
Kidney stones Congenic GHS, WKY Congenic Kidney, SI, FOC RAE230 [37]
  Metabolic syndrome Congenic SHR, WKY Congenic EWAT Spotted [27]
  Hypertension Congenic DS, DR Parental Kidney GF 300 [40]
  1. Tissue abbreviations:ABR: amigdala brain region, EWAT: Epididymal white adipose tissue, FC: frontal cortex, FOC: femoral osteoclast cells, NAC: nucleus accumbens, SI: small intestine. Strain abbreviations:DS: Dahl salt-sensitive, DR: Dahl salt-resistant, GHS: genetic hypercalciuric stone-forming, iP: alcohol non-preferring, LEW: Lewis rats, P: alcohol preferring, SHR: spontaneously hypertensive rat, SHRSP: stroke-prone spontaneously hypertensive rat, SBH/y: Sabra salt-sensitive hypertensive, SBN/y: Sabra salt-resistant normotensive, WKY: Wistar Kyoto.
  2. • Articles included in Table 3.