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Table 1 Published studies analyzing parental strains using the QTL/Microarray approach in rat

From: Serious limitations of the QTL/Microarray approach for QTL gene discovery

 

Phenotype

QTL Mapping

Microarray Experiment

References

  

Design

Strains

Design

Tissues

Platform

 
 

Targeted custom arrays

 

Hypertension

Congenic

DS, LEW

Congenic

Kidney

Custom/

TIGR

[43]

 

Hypertension

F2

DS, LEW

Parental

Kidney

RT-PCR

[31]

 

Whole-Genome arrays

      

Aerobic running capacity

Congenic

DS, DR

Parental

Kidney

RGU34

[34, 95, 96]

 

Alcohol addiction

Congenic

iP, iNP

Congenic

NAC, FC, ABR, hippocampus, striatum

RG230v2

[97]

 

Hypertension

F2

SBH/y, SBN/y

Parental

Kidney

RAE230

[41, 98]

Hypertension

Congenic

DS, LEW

Congenic

Kidney

RGU34

[30]

Hypertension

Congenic

DS, DR

Congenic

Kidney

RGU34

[42, 99]

Hypertension

Congenic

SHRSP, WKY

Congenic

Kidney

RGU34

[44]

 

Hypertension

F2

DS, LEW

Parental

Kidney

RAE230

[32]

 

Hypertension

F2

DS, LEW

Parental

Kidney, adrenal gland, liver, brain

RG230v2

[33]

Kidney stones

Congenic

GHS, WKY

Congenic

Kidney, SI, FOC

RAE230

[37]

 

Metabolic syndrome

Congenic

SHR, WKY

Congenic

EWAT

Spotted

[27]

 

Hypertension

Congenic

DS, DR

Parental

Kidney

GF 300

[40]

  1. Tissue abbreviations:ABR: amigdala brain region, EWAT: Epididymal white adipose tissue, FC: frontal cortex, FOC: femoral osteoclast cells, NAC: nucleus accumbens, SI: small intestine. Strain abbreviations:DS: Dahl salt-sensitive, DR: Dahl salt-resistant, GHS: genetic hypercalciuric stone-forming, iP: alcohol non-preferring, LEW: Lewis rats, P: alcohol preferring, SHR: spontaneously hypertensive rat, SHRSP: stroke-prone spontaneously hypertensive rat, SBH/y: Sabra salt-sensitive hypertensive, SBN/y: Sabra salt-resistant normotensive, WKY: Wistar Kyoto.
  2. • Articles included in Table 3.