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Figure 1 | BMC Biology

Figure 1

From: A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on 13C mass isotopologue profiles under non-steady-state conditions

Figure 1

Biosynthesis of UDP- N -acetyl- D -glucosamine (UDP-GlcNAc). The pathways from [U-13C]-glucose to the four biochemical subunits are outlined. The glucose moiety (red) is directly incorporated into UDP-GlcNAc. The acetyl moiety (blue) is incorporated via glycolysis. The ribose moiety (yellow) is incorporated via the pentose phosphate pathway and pyrimidine biosynthesis. The uracil moiety is derived from acetyl-CoA through the Krebs cycle to form aspartate where it is combined with carbamoyl phosphate leading to pyrimidine synthesis (green).

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