Table 1 Summary of the transporters responsible for the uptake of cytotoxic drugs.

Aminopterin

2

nrt1Δ, fen2Δ

ctr1Δ

nrt1Δ, ctr1Δ

NT

Fail

Amm. pyrrolidine thiocarbamate

20

pca1Δ

NT

NT

Pass

Artesunate

100

fen2Δ (2*σ)

cch1Δ, mid1Δ (2*σ)

NT

NT

Pass

Bay 11-7985

10

fui1Δ

NT

NT

Pass

Benzbromarone

None

28

fui1Δ

NT

NT

Fail

Canavanine

can1Δ

5

can1Δ

can1Δ

pass

Fail

Cantharidin

30

fen2Δ, snq2Δ (2.5*σ)

cch1Δ, mid1Δ, pho89Δ (2.5*σ)

fen2Δ pho89Δ (others NT)

NT

Pass

Cisplatin

50

fcy2Δ, lem3Δ, (fat1Δ, fps1Δ, hnm1Δ 2*σ)

fcy2Δ, (fat1Δ, fps1Δ, hnm1Δ NT)

NT

Pass

Clotrimazole

25

itr1Δ

ftr1Δ fet3Δ

NT

NT

Fail

3,4-Dichloroisocoumarin

8

None

Pass

Diphenyleneiodonium chloride

nrt1Δ

8

nrt1

nrt1Δ

pass

Pass

Fluconazole

100

itr1Δ fcy2Δ

ftr1Δ fet3Δ

NT

NT

Pass

5-Fluorocytosine

158

fcy2

fcy2Δ

NT

Pass

5-Fluorouracil

158

fcy2Δ

fen2Δ

fcy2Δ fen2

NT

Pass

Iodoacetamide

20

mal11Δ (2.5*σ)

Reproducible only on solid

NT

Pass

Ketoconazole

80

itr1Δ fat1Δ

NT

NT

Fail

Methotrexate

100

nrt1Δ

nrt1Δ

pass

Fail

Mitoxantrone

75

agp1

NT

NT

Fail

1,10-Phenanthroline

14

ctr1Δ

NT

NT

Pass

N-Phenylanthranilic Acid

100

None

Pass

Protoporphyrin

600

agp1Δ

NT

NT

Fail

Tamoxifen

730

None

Fail

Tetraethylthiuram disulfide

10

pdr5Δ (2*σ)

NT

NT

Fail

Tunicamycin

4

lem3Δ dnf2Δ qdr2Δ

pca1Δ pho89Δ

all confirmed

NT

Fail

Vanillylmandelic acid

647

None

Pass

ZM 39923

14

None

Fail