Figure 8

Glucose tolerance in male and female adult mice. Mice at three- to nine-months old were examined for their ability to clear a glucose load. Glucose clearance over time is presented graphically for males (A) and females (B). Analysis of the area under each of the glucose concentration curves revealed that Grb10 ^m/+ and Grb10 ^m/+/Dlk1 ^+/p mice of both males (C) and females (D) cleared glucose significantly faster than Dlk1 ^+/p animals. E) Table summarising results of statistical analysis. All values represent means ± SEM and have been subject to one way ANOVA with post hoc Tukey’s analysis. Males: WT n = 14, Dlk1 ^+/p n = 12, Grb10 ^m/+ n = 12 and Grb10 ^m/+/Dlk1 ^+/p n = 13; females: WT n = 13, Dlk1 ^+/p n = 12, Grb10 ^m/+ n = 12 and Grb10 ^m/+/Dlk1 ^+/p n = 12; ** P <0.01. ANOVA, analysis of variance; SEM, standard error of the mean; WT, wild type.