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Fig. 1 | BMC Biology

Fig. 1

From: Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation

Fig. 1

Organization of the C. elegans hermaphroditic gonadal arm. A mitotic zone (MZ) contains stem cells at the distal end, which ensure organ self-renewal as cells are consumed proximally for spermatogenesis (during larval development) or oogenesis and apoptosis (during adulthood). Differentiation of mitotic cells is controlled by opposing factors such as FBF-1/2 and GLD-1, expressed in opposing gradients. The cell cycle regulator cyclin E1 (CYE-1) is expressed throughout the MZ. Subregions are shown that are considered in cell cycle analysis: distal-most mitotic zone (DMMZ), medial mitotic zone (MMZ), and proximal mitotic zone (PMZ). Cell position can be measured by the number of rows to the distal end (rows 1 to 19 are numbered)

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BMC Biology

ISSN: 1741-7007

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