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Fig. 10 | BMC Biology

Fig. 10

From: Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development

Fig. 10

Apc knockout in lung mesenchyme disrupted pulmonary vascular network formation and pulmonary circulation continuity. a The endothelial cells of E13.5 pulmonary vasculature that was connected to the right heart were labeled with FITC-lectin after its intracardial injection, while all mature vascular endothelial cells were immunostained with anti-PECAM1. b Decreased expression of Flk1 at the mRNA level was readily detected in E12.5 Apc CKO lungs, *P < 0.05, n = 5. c Dynamic changes of angioblasts (Flk1+/PECAM1) and mature endothelial cells (Flk1+/PECAM1+) in Apc CKO lung. Reduced angioblasts were detected in Apc CKO lung at E13.5, while both angioblasts and mature endothelial cell numbers appeared significantly reduced in Apc CKO lung at E14.5. d Increased Ctnnb1 activation was not detected in Flk1+ cells in Apc CKO lung. e Reduced expression of Igf1 and Angpt1 at the mRNA level was detected in Apc CKO lungs at E12.5 (*P < 0.05, n = 5)

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