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Fig. 5 | BMC Biology

Fig. 5

From: Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques

Fig. 5

Clone size distributions and total number of sampled clones. a Expected clone size distributions C −1m q 〉 derived from the approximation in Additional file 1: Eq. A32 are plotted for various a and δ/(ε w) [where w≡(1+η)ω/μ d]. The nearly coincident solid and dashed curves indicate that variations in a mainly scale the distribution by a multiplicative factor. In contrast, the combination δ/(ε w) controls the weighting at large clone sizes through the population cut-off imposed by the carrying capacity. Of the two controlling parameters, the steady-state clone size distribution is most sensitive to Rδ/(ε w). The dependence of data-fitting on these two parameters is derived in Additional file 1 and discussed in the next section. b For ε w=5×10−5, the expected fraction C s/C of active clones sampled as a function of lnδ and α. The expected number of clones sampled increases with carrying capacity K, HSC differentiation rate a=α/r, and the combined sampling and terminal differentiation rate ε w

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