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Fig. 3 | BMC Biology

Fig. 3

From: Drosophila innate immunity: regional and functional specialization of prophenoloxidases

Fig. 3

Contribution of PPO1,2 and PPO3 to host defense against bacteria and fungi. Survival rates of flies following septic injury with Gram-positive lysine-type bacteria (Staphylococcus aureus and Enterococcus faecalis), Gram-positive DAP-type bacterium (Bacillus subtilis) and natural infection with the entomopathogenic fungus Beauveria bassiana. Flies lacking the Toll ligand spätzle were used as immune-deficient controls. The x-axis is the time post-infection in days and the y-axis is the percentage of living flies. PPO1 Δ ,2 Δ and PPO1 Δ ,2 Δ ,3 1 flies are less resistant to infections with S. aureus (P < 0.0001), Enterococcus faecalis (P < 0.0001), Bacillus subtilis (P < 0.0001) and Beauveria bassiana (P < 0.0005) compared to wild-type flies. Differences between PPO3 SK3 and w 1118 do not reach statistical significance. Data were analyzed by a log-rank test

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