Fig. 1
From: Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate
Mesodermal progenitor-specific deletion of Alk5 reduced the sub-mesothelial mesenchyme. (a–f) Gross morphology (a, d, b, and e) and hematoxylin and eosin staining (c and f) show decreased sub-mesothelial mesenchyme in Alk5 Dermo1 mutant lungs at E12.5 (b, e, c, and f) or E13.5 (a and d). (g) Quantitative PCR showed decreased Fgf 7, Fgf9, and Fgf10 mRNA in E13.5 Alk5 Dermo1 lungs; n = 2 controls and 3 mutant lungs. (h) Western blot analysis showed decreased FGF signaling target genes. β-ACTIN was used as control, n = 3. Error bars show standard deviation. Scale bar: f = 20 μm