Fig. 4

Immature adult-born neurons improve pattern-separation in the DG by enhancing feedback inhibition. Two events are encoded in separate but partially overlapping populations of activated DGCs in the DG (red and green, with overlap in yellow). DGCs receive strong inhibitory inputs from interneurons (purple) in the hilus and sub-granular zone. It is hypothesized that hyperactive immature adult-born DGCs (blue) drive these interneurons, enhancing feedback inhibition from the hilus, which results in decreased overlap of activated DGCs and output to CA3, thereby improving pattern separation