Fig. 1

hnRNP A1 iCLIP identified UAGG as the hnRNP A1 binding motif. a Consensus hnRNP A1 binding motifs were generated based on the identified hnRNP A1 binding peaks. The most highly enriched motif and the frequency matrix are shown. b The distribution of hnRNP A1 iCLIP crosslinking sites in different genomic regions (pie chart). hnRNP A1 iCLIP crosslinking sites are most prevalent in introns. However, when accounting for the relative size of each genomic region, there is an enrichment of hnRNP A1 crosslinking sites in the 3′ UTR (bar chart). CDS coding sequence. c The distribution of hnRNP A1 binding peaks across introns, including 100 bases of the adjacent exons. hnRNP A1 binds deep introns more than proximal introns close to exons. Shaded region corresponds to the 95 % confidence interval. d The distribution of hnRNP A1 binding peaks across exons including 100 bp of the adjacent introns. Internal exons (green) defined as all exons except the first and last exon, and cassette exons (orange) defined as alternative internal exons. hnRNP A1 binding peaks are highly enriched downstream of the 5′ splice site, more so for cassette exons than internal exons in general. Shaded region corresponds to the 95 % confidence interval