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Table 3 Average ensemble outcome R g and D max from EOM 2.0 together with the χ value and the quantification of flexibility (R flex) for each N-Cbl variant

From: Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation

N-Cbl variant R g (nm) D max (nm) Fit (χ value) R flex (%)
Y371F 2.38 7.67 1.284 56
WT 2.41 7.89 0.831 60
Y368F 2.46 8.37 0.778 65
M222E 2.44 8.05 1.030 65
Y371H 2.44 8.24 0.695 69
Y371A 2.52 8.16 1.020 75
Y371S 2.61 8.89 0.774 84
Y371D 2.64 8.91 0.814 88
Y371E 2.79 9.43 0.773 90