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Fig. 1 | BMC Biology

Fig. 1

From: Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders

Fig. 1

Modeling of mFAO in wild-type and MCAD-knockout mouse liver. a Schematic representation of fatty acid β-oxidation. Reactions in black are part of the computational model, reactions in grey are not in the model, but are discussed in the text and dashed arrows are sink reactions. b Examples of rate equations used for the model with and without competition. CPT1 carnitine palmitoyltransferase 1, CACT carnitine acylcarnitine translocase, CPT2 carnitine palmitoyltransferase 2, SCAD short-chain acyl-CoA dehydrogenase, MCAD medium-chain acyl-CoA dehydrogenase, LCAD long-chain acyl-CoA dehydrogenase (not present in human mFAO (grey)), VLCAD very-long-chain acyl-CoA dehydrogenase, CROT crotonase, M/SCHAD medium/short-chain hydroxyacyl-CoA dehydrogenase, MCKAT medium-chain ketoacyl-CoA thiolase, MTP mitochondrial trifunctional protein, ETF electron transfer flavoprotein

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BMC Biology

ISSN: 1741-7007

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