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Fig. 6 | BMC Biology

Fig. 6

From: Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain

Fig. 6

Normal levels of Mov10 are required for normal neuronal morphology. a 25 μg of total brain extract from P2 mice (genotypes shown above: HET is the Mov10 heterozygote, missing one copy of Mov10) immunoblotted for Mov10 and eIF5α. Immunoblot quantification (n = 3), error bars represent SD, * p< 0.05 (Student’s t test, two-tailed). b and c Map2 immunostaining of hippocampal neurons from DIV14 WT (b) and Mov10 heterozygous (c) neurons. d Dendritic morphology analysis. Confocal z-stacks of Map2-stained WT or Mov10 heterozygote DIV14 neurons were analyzed using Sholl. Statistics were calculated using two-way ANOVA followed by Bonferroni multiple comparisons test. Error bars indicate SEM and *p < 0.05. (n = 56 neurons for WT, and n = 94 neurons for Mov10 HET)

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