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Table 1 Human autosomes with common trisomies, in ascending order of number of ohnologs

From: Dosage-sensitive genes in evolution and disease

Human chromosome number Number of dosage-balanced ohnologsa Trisomy syndrome Frequency (number of live births)b
21 61 Down's 1/700
18 98 Edward's 1/5000
13 138 Patau 1/16,000
  1. aIdentified from gene trees in Ensembl v86 [109] as genes that duplicated at the base of the vertebrate tree with no subsequent SSD
  2. bFrequency data from [90] and ghr.nlm.nih.gov/trisomy-18; ghr.nlm.nih.gov/trisomy-13